Gigaxonin E3 ligase governs ATG16L1 turnover to control autophagosome production

Membrane elongation is fundamental to autophagy and is controlled by an ubiquitin-conjugating cascade orchestrated by ATG16L1. Here, the authors identify that the E3 ligase Gigaxonin regulates autophagosome formation by controlling ATG16L1 turnover.

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Auteurs principaux:	Aurora Scrivo, Patrice Codogno, Pascale Bomont
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/2e1c17d96cec4e74b80786a4cfe81395
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spelling	oai:doaj.org-article:2e1c17d96cec4e74b80786a4cfe813952021-12-02T14:38:38ZGigaxonin E3 ligase governs ATG16L1 turnover to control autophagosome production10.1038/s41467-019-08331-w2041-1723https://doaj.org/article/2e1c17d96cec4e74b80786a4cfe813952019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08331-whttps://doaj.org/toc/2041-1723Membrane elongation is fundamental to autophagy and is controlled by an ubiquitin-conjugating cascade orchestrated by ATG16L1. Here, the authors identify that the E3 ligase Gigaxonin regulates autophagosome formation by controlling ATG16L1 turnover.Aurora ScrivoPatrice CodognoPascale BomontNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aurora Scrivo Patrice Codogno Pascale Bomont Gigaxonin E3 ligase governs ATG16L1 turnover to control autophagosome production
description	Membrane elongation is fundamental to autophagy and is controlled by an ubiquitin-conjugating cascade orchestrated by ATG16L1. Here, the authors identify that the E3 ligase Gigaxonin regulates autophagosome formation by controlling ATG16L1 turnover.
format	article
author	Aurora Scrivo Patrice Codogno Pascale Bomont
author_facet	Aurora Scrivo Patrice Codogno Pascale Bomont
author_sort	Aurora Scrivo
title	Gigaxonin E3 ligase governs ATG16L1 turnover to control autophagosome production
title_short	Gigaxonin E3 ligase governs ATG16L1 turnover to control autophagosome production
title_full	Gigaxonin E3 ligase governs ATG16L1 turnover to control autophagosome production
title_fullStr	Gigaxonin E3 ligase governs ATG16L1 turnover to control autophagosome production
title_full_unstemmed	Gigaxonin E3 ligase governs ATG16L1 turnover to control autophagosome production
title_sort	gigaxonin e3 ligase governs atg16l1 turnover to control autophagosome production
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2e1c17d96cec4e74b80786a4cfe81395
work_keys_str_mv	AT aurorascrivo gigaxonine3ligasegovernsatg16l1turnovertocontrolautophagosomeproduction AT patricecodogno gigaxonine3ligasegovernsatg16l1turnovertocontrolautophagosomeproduction AT pascalebomont gigaxonine3ligasegovernsatg16l1turnovertocontrolautophagosomeproduction
_version_	1718390883175366656

Gigaxonin E3 ligase governs ATG16L1 turnover to control autophagosome production

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