Cellular correlates of cortical thinning throughout the lifespan

Abstract Cortical thinning occurs throughout the entire life and extends to late-life neurodegeneration, yet the neurobiological substrates are poorly understood. Here, we used a virtual-histology technique and gene expression data from the Allen Human Brain Atlas to compare the regional profiles of...

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Autores principales:	Didac Vidal-Pineiro, Nadine Parker, Jean Shin, Leon French, Håkon Grydeland, Andrea P. Jackowski, Athanasia M. Mowinckel, Yash Patel, Zdenka Pausova, Giovanni Salum, Øystein Sørensen, Kristine B. Walhovd, Tomas Paus, Anders M. Fjell, the Alzheimer’s Disease Neuroimaging Initiative and the Australian Imaging Biomarkers and Lifestyle flagship study of ageing
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2e1c3515955d47a5a3ce5e1222c5cc1b
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spelling	oai:doaj.org-article:2e1c3515955d47a5a3ce5e1222c5cc1b2021-12-02T15:11:51ZCellular correlates of cortical thinning throughout the lifespan10.1038/s41598-020-78471-32045-2322https://doaj.org/article/2e1c3515955d47a5a3ce5e1222c5cc1b2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78471-3https://doaj.org/toc/2045-2322Abstract Cortical thinning occurs throughout the entire life and extends to late-life neurodegeneration, yet the neurobiological substrates are poorly understood. Here, we used a virtual-histology technique and gene expression data from the Allen Human Brain Atlas to compare the regional profiles of longitudinal cortical thinning through life (4004 magnetic resonance images [MRIs]) with those of gene expression for several neuronal and non-neuronal cell types. The results were replicated in three independent datasets. We found that inter-regional profiles of cortical thinning related to expression profiles for marker genes of CA1 pyramidal cells, astrocytes and, microglia during development and in aging. During the two stages of life, the relationships went in opposite directions: greater gene expression related to less thinning in development and vice versa in aging. The association between cortical thinning and cell-specific gene expression was also present in mild cognitive impairment and Alzheimer’s Disease. These findings suggest a role of astrocytes and microglia in promoting and supporting neuronal growth and dendritic structures through life that affects cortical thickness during development, aging, and neurodegeneration. Overall, the findings contribute to our understanding of the neurobiology underlying variations in MRI-derived estimates of cortical thinning through life and late-life disease.Didac Vidal-PineiroNadine ParkerJean ShinLeon FrenchHåkon GrydelandAndrea P. JackowskiAthanasia M. MowinckelYash PatelZdenka PausovaGiovanni SalumØystein SørensenKristine B. WalhovdTomas PausAnders M. Fjellthe Alzheimer’s Disease Neuroimaging Initiative and the Australian Imaging Biomarkers and Lifestyle flagship study of ageingNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Didac Vidal-Pineiro Nadine Parker Jean Shin Leon French Håkon Grydeland Andrea P. Jackowski Athanasia M. Mowinckel Yash Patel Zdenka Pausova Giovanni Salum Øystein Sørensen Kristine B. Walhovd Tomas Paus Anders M. Fjell the Alzheimer’s Disease Neuroimaging Initiative and the Australian Imaging Biomarkers and Lifestyle flagship study of ageing Cellular correlates of cortical thinning throughout the lifespan
description	Abstract Cortical thinning occurs throughout the entire life and extends to late-life neurodegeneration, yet the neurobiological substrates are poorly understood. Here, we used a virtual-histology technique and gene expression data from the Allen Human Brain Atlas to compare the regional profiles of longitudinal cortical thinning through life (4004 magnetic resonance images [MRIs]) with those of gene expression for several neuronal and non-neuronal cell types. The results were replicated in three independent datasets. We found that inter-regional profiles of cortical thinning related to expression profiles for marker genes of CA1 pyramidal cells, astrocytes and, microglia during development and in aging. During the two stages of life, the relationships went in opposite directions: greater gene expression related to less thinning in development and vice versa in aging. The association between cortical thinning and cell-specific gene expression was also present in mild cognitive impairment and Alzheimer’s Disease. These findings suggest a role of astrocytes and microglia in promoting and supporting neuronal growth and dendritic structures through life that affects cortical thickness during development, aging, and neurodegeneration. Overall, the findings contribute to our understanding of the neurobiology underlying variations in MRI-derived estimates of cortical thinning through life and late-life disease.
format	article
author	Didac Vidal-Pineiro Nadine Parker Jean Shin Leon French Håkon Grydeland Andrea P. Jackowski Athanasia M. Mowinckel Yash Patel Zdenka Pausova Giovanni Salum Øystein Sørensen Kristine B. Walhovd Tomas Paus Anders M. Fjell the Alzheimer’s Disease Neuroimaging Initiative and the Australian Imaging Biomarkers and Lifestyle flagship study of ageing
author_facet	Didac Vidal-Pineiro Nadine Parker Jean Shin Leon French Håkon Grydeland Andrea P. Jackowski Athanasia M. Mowinckel Yash Patel Zdenka Pausova Giovanni Salum Øystein Sørensen Kristine B. Walhovd Tomas Paus Anders M. Fjell the Alzheimer’s Disease Neuroimaging Initiative and the Australian Imaging Biomarkers and Lifestyle flagship study of ageing
author_sort	Didac Vidal-Pineiro
title	Cellular correlates of cortical thinning throughout the lifespan
title_short	Cellular correlates of cortical thinning throughout the lifespan
title_full	Cellular correlates of cortical thinning throughout the lifespan
title_fullStr	Cellular correlates of cortical thinning throughout the lifespan
title_full_unstemmed	Cellular correlates of cortical thinning throughout the lifespan
title_sort	cellular correlates of cortical thinning throughout the lifespan
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2e1c3515955d47a5a3ce5e1222c5cc1b
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Cellular correlates of cortical thinning throughout the lifespan

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