Exploring the role of epidermal growth factor receptor variant III in meningeal tumors.

Meningioma is the second most common type of intracranial brain tumor. Immunohistochemical techniques have shown prodigious results in the role of epidermal growth factor receptor variant III (EGFR vIII) in glioma and other cancers. However, the role of EGFR vIII in meningioma is still in question....

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Autores principales:	Rashmi Rana, Vaishnavi Rathi, Kirti Chauhan, Kriti Jain, Satnam Singh Chhabra, Rajesh Acharya, Samir Kumar Kalra, Anshul Gupta, Sunila Jain, Nirmal Kumar Ganguly, Dharmendra Kumar Yadav
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2e1cf56cac824608b3af18e8553018c3
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spelling	oai:doaj.org-article:2e1cf56cac824608b3af18e8553018c32021-12-02T20:14:06ZExploring the role of epidermal growth factor receptor variant III in meningeal tumors.1932-620310.1371/journal.pone.0255133https://doaj.org/article/2e1cf56cac824608b3af18e8553018c32021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255133https://doaj.org/toc/1932-6203Meningioma is the second most common type of intracranial brain tumor. Immunohistochemical techniques have shown prodigious results in the role of epidermal growth factor receptor variant III (EGFR vIII) in glioma and other cancers. However, the role of EGFR vIII in meningioma is still in question. This study attempt the confer searches for the position attained by EGFR vIII in progression and expression of meningioma. Immunohistochemistry technique showed that EGFR vIII is highly expressed in benign tumors as compared to the atypical meningioma with a highly significant p-value (p<0.05). Further analysis by flow cytometry results supported these findings thus presented high intensity of EGFR vIII in low grades of meningioma. The study revealed that the significant Ki 67 values, to predictor marker for survival and prognosis of the patients. Higher expression of EGFR vIII in low grades meningiomas as compared to high-grade tumors indicate towards its oncogenic properties. To our knowledge, limited studies reported in literature expressing the EGFR vIII in meningioma tumors. Hence, Opinions regarding the role that EGFR vIII in tumorigenesis and tumor progression are clearly conflicting and, therefore, it is crucial not only to find out its mechanism of action, but also to definitely identify its role in meningioma.Rashmi RanaVaishnavi RathiKirti ChauhanKriti JainSatnam Singh ChhabraRajesh AcharyaSamir Kumar KalraAnshul GuptaSunila JainNirmal Kumar GangulyDharmendra Kumar YadavPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0255133 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rashmi Rana Vaishnavi Rathi Kirti Chauhan Kriti Jain Satnam Singh Chhabra Rajesh Acharya Samir Kumar Kalra Anshul Gupta Sunila Jain Nirmal Kumar Ganguly Dharmendra Kumar Yadav Exploring the role of epidermal growth factor receptor variant III in meningeal tumors.
description	Meningioma is the second most common type of intracranial brain tumor. Immunohistochemical techniques have shown prodigious results in the role of epidermal growth factor receptor variant III (EGFR vIII) in glioma and other cancers. However, the role of EGFR vIII in meningioma is still in question. This study attempt the confer searches for the position attained by EGFR vIII in progression and expression of meningioma. Immunohistochemistry technique showed that EGFR vIII is highly expressed in benign tumors as compared to the atypical meningioma with a highly significant p-value (p<0.05). Further analysis by flow cytometry results supported these findings thus presented high intensity of EGFR vIII in low grades of meningioma. The study revealed that the significant Ki 67 values, to predictor marker for survival and prognosis of the patients. Higher expression of EGFR vIII in low grades meningiomas as compared to high-grade tumors indicate towards its oncogenic properties. To our knowledge, limited studies reported in literature expressing the EGFR vIII in meningioma tumors. Hence, Opinions regarding the role that EGFR vIII in tumorigenesis and tumor progression are clearly conflicting and, therefore, it is crucial not only to find out its mechanism of action, but also to definitely identify its role in meningioma.
format	article
author	Rashmi Rana Vaishnavi Rathi Kirti Chauhan Kriti Jain Satnam Singh Chhabra Rajesh Acharya Samir Kumar Kalra Anshul Gupta Sunila Jain Nirmal Kumar Ganguly Dharmendra Kumar Yadav
author_facet	Rashmi Rana Vaishnavi Rathi Kirti Chauhan Kriti Jain Satnam Singh Chhabra Rajesh Acharya Samir Kumar Kalra Anshul Gupta Sunila Jain Nirmal Kumar Ganguly Dharmendra Kumar Yadav
author_sort	Rashmi Rana
title	Exploring the role of epidermal growth factor receptor variant III in meningeal tumors.
title_short	Exploring the role of epidermal growth factor receptor variant III in meningeal tumors.
title_full	Exploring the role of epidermal growth factor receptor variant III in meningeal tumors.
title_fullStr	Exploring the role of epidermal growth factor receptor variant III in meningeal tumors.
title_full_unstemmed	Exploring the role of epidermal growth factor receptor variant III in meningeal tumors.
title_sort	exploring the role of epidermal growth factor receptor variant iii in meningeal tumors.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/2e1cf56cac824608b3af18e8553018c3
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Exploring the role of epidermal growth factor receptor variant III in meningeal tumors.

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