Gender differences in the relationships among neurosteroid serum levels, cognitive function, and quality of life

Chien-Yu Chen,1 Chih-Ching Wu,2,3 Yu-Chi Huang,1 Chi-Fa Hung,1 Liang-Jen Wang4 1Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan; 2Molecular Medicine Research Center, Chang Gung University, Tao-Yuan, Taiwan; 3Department o...

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Autores principales:	Chen CY, Wu CC, Huang YC, Hung CF, Wang LJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	endocrinology DHEA pregnenolone cognition quality of life Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/2e1d86ef17224b0b97f0c226d74f8420
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spelling	oai:doaj.org-article:2e1d86ef17224b0b97f0c226d74f84202021-12-02T04:08:59ZGender differences in the relationships among neurosteroid serum levels, cognitive function, and quality of life1178-2021https://doaj.org/article/2e1d86ef17224b0b97f0c226d74f84202018-09-01T00:00:00Zhttps://www.dovepress.com/gender-differences-in-the-relationships-among-neurosteroid-serum-level-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Chien-Yu Chen,1 Chih-Ching Wu,2,3 Yu-Chi Huang,1 Chi-Fa Hung,1 Liang-Jen Wang4 1Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan; 2Molecular Medicine Research Center, Chang Gung University, Tao-Yuan, Taiwan; 3Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Tao-Yuan, Taiwan; 4Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan Background: Dehydroepiandrosterone (DHEA), its sulfate ester (DHEA-S), and pregnenolone are neurosteroids that can be synthesized in the brain. Previous studies have hypothesized that these neurosteroids have antiaging, mood-enhancing, and cognitive-preserving effects; however, these effects may be gender-specific. Therefore, the purpose of this study was to investigate the gender differences in the relationships among neurosteroids (DHEA, DHEA-S, and pregnenolone), cognitive function, and quality of life in healthy individuals. Method: In this cross-sectional study, we enrolled 47 men (mean age: 32.8 years) and 75 women (mean age: 35.4 years) who had no major physical or psychiatric illnesses and measured their serum DHEA, DHEA-S, and pregnenolone. Furthermore, we evaluated the subjects’ cognitive function and quality of life using the Brief Assessment of Cognition in Schizophrenia and the World Health Organization Quality of Life Scale, respectively. Results: The serum levels of DHEA and DHEA-S demonstrated significant gender differences, even after controlling for age effect. In the male subjects, the DHEA serum levels were positively correlated with three domains of the World Health Organization Quality of Life Scale, including physical health, social relations, and environmental dimensions. Meanwhile, the DHEA-S levels positively correlated with the performance of working memory, and pregnenolone levels had a positive correlation with working memory, verbal fluency, and Brief Assessment of Cognition in Schizophrenia composite score. However, in the female subjects, we observed a correlation only between the serum levels of DHEA-S and working memory. Conclusion: The findings of our study indicate that neurosteroids play a vital role in cognitive function and quality of life among men but less so among women. Nevertheless, the underlying mechanisms of the gender-specific effect of neurosteroids require further investigation. Keywords: endocrinology, DHEA, pregnenolone, cognition, quality of lifeChen CYWu CCHuang YCHung CFWang LJDove Medical PressarticleendocrinologyDHEApregnenolonecognitionquality of lifeNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 2389-2399 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	endocrinology DHEA pregnenolone cognition quality of life Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	endocrinology DHEA pregnenolone cognition quality of life Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Chen CY Wu CC Huang YC Hung CF Wang LJ Gender differences in the relationships among neurosteroid serum levels, cognitive function, and quality of life
description	Chien-Yu Chen,1 Chih-Ching Wu,2,3 Yu-Chi Huang,1 Chi-Fa Hung,1 Liang-Jen Wang4 1Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan; 2Molecular Medicine Research Center, Chang Gung University, Tao-Yuan, Taiwan; 3Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Tao-Yuan, Taiwan; 4Department of Child and Adolescent Psychiatry, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan Background: Dehydroepiandrosterone (DHEA), its sulfate ester (DHEA-S), and pregnenolone are neurosteroids that can be synthesized in the brain. Previous studies have hypothesized that these neurosteroids have antiaging, mood-enhancing, and cognitive-preserving effects; however, these effects may be gender-specific. Therefore, the purpose of this study was to investigate the gender differences in the relationships among neurosteroids (DHEA, DHEA-S, and pregnenolone), cognitive function, and quality of life in healthy individuals. Method: In this cross-sectional study, we enrolled 47 men (mean age: 32.8 years) and 75 women (mean age: 35.4 years) who had no major physical or psychiatric illnesses and measured their serum DHEA, DHEA-S, and pregnenolone. Furthermore, we evaluated the subjects’ cognitive function and quality of life using the Brief Assessment of Cognition in Schizophrenia and the World Health Organization Quality of Life Scale, respectively. Results: The serum levels of DHEA and DHEA-S demonstrated significant gender differences, even after controlling for age effect. In the male subjects, the DHEA serum levels were positively correlated with three domains of the World Health Organization Quality of Life Scale, including physical health, social relations, and environmental dimensions. Meanwhile, the DHEA-S levels positively correlated with the performance of working memory, and pregnenolone levels had a positive correlation with working memory, verbal fluency, and Brief Assessment of Cognition in Schizophrenia composite score. However, in the female subjects, we observed a correlation only between the serum levels of DHEA-S and working memory. Conclusion: The findings of our study indicate that neurosteroids play a vital role in cognitive function and quality of life among men but less so among women. Nevertheless, the underlying mechanisms of the gender-specific effect of neurosteroids require further investigation. Keywords: endocrinology, DHEA, pregnenolone, cognition, quality of life
format	article
author	Chen CY Wu CC Huang YC Hung CF Wang LJ
author_facet	Chen CY Wu CC Huang YC Hung CF Wang LJ
author_sort	Chen CY
title	Gender differences in the relationships among neurosteroid serum levels, cognitive function, and quality of life
title_short	Gender differences in the relationships among neurosteroid serum levels, cognitive function, and quality of life
title_full	Gender differences in the relationships among neurosteroid serum levels, cognitive function, and quality of life
title_fullStr	Gender differences in the relationships among neurosteroid serum levels, cognitive function, and quality of life
title_full_unstemmed	Gender differences in the relationships among neurosteroid serum levels, cognitive function, and quality of life
title_sort	gender differences in the relationships among neurosteroid serum levels, cognitive function, and quality of life
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/2e1d86ef17224b0b97f0c226d74f8420
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Gender differences in the relationships among neurosteroid serum levels, cognitive function, and quality of life

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