Proteinuria is independently associated with carotid atherosclerosis: a multicentric study

Abstract Background and aims Atherosclerosis is a vital cause of cardiovascular diseases. The correlation between proteinuria and atherosclerosis, however, has not been confirmed. This study aimed to assess whether there is a relationship between proteinuria and atherosclerosis. Methods From January...

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Autores principales:	Wencai Jiang, Meixiang Chen, Jianyu Huang, Yu Shang, Changyu Qin, Zheng Ruan, Shuang Li, Ruixin Wang, Pengfei Li, Yuekang Huang, Jianxiong Liu, Lin Xu
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Atherosclerosis Proteinuria Cardiovascular diseases Risk factors Epidemiology Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/2e1facb2db6d4ac698342a0ee73cb395
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spelling	oai:doaj.org-article:2e1facb2db6d4ac698342a0ee73cb3952021-11-21T12:03:58ZProteinuria is independently associated with carotid atherosclerosis: a multicentric study10.1186/s12872-021-02367-x1471-2261https://doaj.org/article/2e1facb2db6d4ac698342a0ee73cb3952021-11-01T00:00:00Zhttps://doi.org/10.1186/s12872-021-02367-xhttps://doaj.org/toc/1471-2261Abstract Background and aims Atherosclerosis is a vital cause of cardiovascular diseases. The correlation between proteinuria and atherosclerosis, however, has not been confirmed. This study aimed to assess whether there is a relationship between proteinuria and atherosclerosis. Methods From January 2016 to September 2020, 13,545 asymptomatic subjects from four centres in southern China underwent dipstick proteinuria testing and carotid atherosclerosis examination. Data on demography and past medical history were collected, and laboratory examinations were performed. The samples consisted of 7405 subjects (4875 males and 2530 females), excluding subjects failing to reach predefined standards and containing enough information. A multivariate logistic regression model was used to adjust the influence of traditional risk factors for atherosclerosis on the results. Results Compared with proteinuria-negative subjects, proteinuria-positive subjects had a higher prevalence rate of carotid atherosclerosis. The differences were statistically significant (22.6% vs. 26.7%, χ2 = 10.03, p = 0.002). After adjusting for common risk factors for atherosclerosis, age, sex, BMI, blood lipids, blood pressure, renal function, hypertensive disease, diabetes mellitus and hyperlipidaemia, proteinuria was an independent risk factor for atherosclerosis (OR = 1.191, 95% CI 1.015–1.398, p = 0.033). The Hosmer–Lemeshow test was used to test the risk prediction model of atherosclerosis, and the results showed that the model has high goodness of fit and strong independent variable prediction ability. Conclusions Proteinuria is independently related to carotid atherosclerosis. With the increase in proteinuria level, the risk of carotid atherosclerotic plaque increases. For patients with positive proteinuria, further examination of atherosclerosis should not be ignored.Wencai JiangMeixiang ChenJianyu HuangYu ShangChangyu QinZheng RuanShuang LiRuixin WangPengfei LiYuekang HuangJianxiong LiuLin XuBMCarticleAtherosclerosisProteinuriaCardiovascular diseasesRisk factorsEpidemiologyDiseases of the circulatory (Cardiovascular) systemRC666-701ENBMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Atherosclerosis Proteinuria Cardiovascular diseases Risk factors Epidemiology Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Atherosclerosis Proteinuria Cardiovascular diseases Risk factors Epidemiology Diseases of the circulatory (Cardiovascular) system RC666-701 Wencai Jiang Meixiang Chen Jianyu Huang Yu Shang Changyu Qin Zheng Ruan Shuang Li Ruixin Wang Pengfei Li Yuekang Huang Jianxiong Liu Lin Xu Proteinuria is independently associated with carotid atherosclerosis: a multicentric study
description	Abstract Background and aims Atherosclerosis is a vital cause of cardiovascular diseases. The correlation between proteinuria and atherosclerosis, however, has not been confirmed. This study aimed to assess whether there is a relationship between proteinuria and atherosclerosis. Methods From January 2016 to September 2020, 13,545 asymptomatic subjects from four centres in southern China underwent dipstick proteinuria testing and carotid atherosclerosis examination. Data on demography and past medical history were collected, and laboratory examinations were performed. The samples consisted of 7405 subjects (4875 males and 2530 females), excluding subjects failing to reach predefined standards and containing enough information. A multivariate logistic regression model was used to adjust the influence of traditional risk factors for atherosclerosis on the results. Results Compared with proteinuria-negative subjects, proteinuria-positive subjects had a higher prevalence rate of carotid atherosclerosis. The differences were statistically significant (22.6% vs. 26.7%, χ2 = 10.03, p = 0.002). After adjusting for common risk factors for atherosclerosis, age, sex, BMI, blood lipids, blood pressure, renal function, hypertensive disease, diabetes mellitus and hyperlipidaemia, proteinuria was an independent risk factor for atherosclerosis (OR = 1.191, 95% CI 1.015–1.398, p = 0.033). The Hosmer–Lemeshow test was used to test the risk prediction model of atherosclerosis, and the results showed that the model has high goodness of fit and strong independent variable prediction ability. Conclusions Proteinuria is independently related to carotid atherosclerosis. With the increase in proteinuria level, the risk of carotid atherosclerotic plaque increases. For patients with positive proteinuria, further examination of atherosclerosis should not be ignored.
format	article
author	Wencai Jiang Meixiang Chen Jianyu Huang Yu Shang Changyu Qin Zheng Ruan Shuang Li Ruixin Wang Pengfei Li Yuekang Huang Jianxiong Liu Lin Xu
author_facet	Wencai Jiang Meixiang Chen Jianyu Huang Yu Shang Changyu Qin Zheng Ruan Shuang Li Ruixin Wang Pengfei Li Yuekang Huang Jianxiong Liu Lin Xu
author_sort	Wencai Jiang
title	Proteinuria is independently associated with carotid atherosclerosis: a multicentric study
title_short	Proteinuria is independently associated with carotid atherosclerosis: a multicentric study
title_full	Proteinuria is independently associated with carotid atherosclerosis: a multicentric study
title_fullStr	Proteinuria is independently associated with carotid atherosclerosis: a multicentric study
title_full_unstemmed	Proteinuria is independently associated with carotid atherosclerosis: a multicentric study
title_sort	proteinuria is independently associated with carotid atherosclerosis: a multicentric study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/2e1facb2db6d4ac698342a0ee73cb395
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Proteinuria is independently associated with carotid atherosclerosis: a multicentric study

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