Oral bioavailability enhancement of agomelatine by loading into nanostructured lipid carriers: Peyer’s patch targeting approach

Oral bioavailability enhancement of agomelatine by loading into nanostructured lipid carriers: Peyer’s patch targeting approach

Jagruti B Prajapati, Sneha D Verma, Amit A Patel Department of Ppharmaceutics and Ppharmaceutical Technology, Rramanbhai Patel College of Ppharmacy, Charotar University of Science and Technology, Changa, Gujarat, India Abstract: Agomelatine (AGM) is a new antidepressant drug with a novel mechanism...

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Autores principales: Prajapati JB, Verma SD, Patel AA
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2018
Materias:
Agomelatine
Nano structures Lipid Carriers
antidepressant drug
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/2e1fcfa1c1b54a0d8073a272f35ae2d0
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spelling oai:doaj.org-article:2e1fcfa1c1b54a0d8073a272f35ae2d02021-12-02T06:55:43ZOral bioavailability enhancement of agomelatine by loading into nanostructured lipid carriers: Peyer’s patch targeting approach1178-2013https://doaj.org/article/2e1fcfa1c1b54a0d8073a272f35ae2d02018-03-01T00:00:00Zhttps://www.dovepress.com/oral-bioavailability-enhancement-of-agomelatine-by-loading-into-nanost-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Jagruti B Prajapati, Sneha D Verma, Amit A Patel Department of Ppharmaceutics and Ppharmaceutical Technology, Rramanbhai Patel College of Ppharmacy, Charotar University of Science and Technology, Changa, Gujarat, India Abstract: Agomelatine (AGM) is a new antidepressant drug with a novel mechanism of action and fewer side effects compared with older antidepressants. AGM is a melatonin receptor (MT1 and MT2) agonist and 5-hydroxytryptamine receptor (5-HT2C) antagonist. In the present study, the enhancement of the oral bioavailability of AGM was formulated and loaded into nanostructured lipid carriers (NLCs), using ultrasonication method. In vitro and ex vivo drug release was performed using a dialysis bag and rat duodenum, respectively. Our pharmacodynamic study showed that AGM–NLCs are more efficacious than a pure drug and marketed product, and confocal microscopy revealed lymphatic uptake of AGM–NLCs. The present study concluded that the NLCs enhanced the oral bioavailability of AGM (6.5-fold) by avoiding its first-pass metabolism by way of lymphatic uptake. Keywords: agomelatine, nanostructured lipid carriers, antidepressant drugPrajapati JBVerma SDPatel AADove Medical PressarticleAgomelatineNano structures Lipid Carriersantidepressant drugMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 35-38 (2018)
institution DOAJ
collection DOAJ
language EN
topic Agomelatine
Nano structures Lipid Carriers
antidepressant drug
Medicine (General)
R5-920
spellingShingle Agomelatine
Nano structures Lipid Carriers
antidepressant drug
Medicine (General)
R5-920
Prajapati JB
Verma SD
Patel AA
Oral bioavailability enhancement of agomelatine by loading into nanostructured lipid carriers: Peyer’s patch targeting approach
description Jagruti B Prajapati, Sneha D Verma, Amit A Patel Department of Ppharmaceutics and Ppharmaceutical Technology, Rramanbhai Patel College of Ppharmacy, Charotar University of Science and Technology, Changa, Gujarat, India Abstract: Agomelatine (AGM) is a new antidepressant drug with a novel mechanism of action and fewer side effects compared with older antidepressants. AGM is a melatonin receptor (MT1 and MT2) agonist and 5-hydroxytryptamine receptor (5-HT2C) antagonist. In the present study, the enhancement of the oral bioavailability of AGM was formulated and loaded into nanostructured lipid carriers (NLCs), using ultrasonication method. In vitro and ex vivo drug release was performed using a dialysis bag and rat duodenum, respectively. Our pharmacodynamic study showed that AGM–NLCs are more efficacious than a pure drug and marketed product, and confocal microscopy revealed lymphatic uptake of AGM–NLCs. The present study concluded that the NLCs enhanced the oral bioavailability of AGM (6.5-fold) by avoiding its first-pass metabolism by way of lymphatic uptake. Keywords: agomelatine, nanostructured lipid carriers, antidepressant drug
format article
author Prajapati JB
Verma SD
Patel AA
author_facet Prajapati JB
Verma SD
Patel AA
author_sort Prajapati JB
title Oral bioavailability enhancement of agomelatine by loading into nanostructured lipid carriers: Peyer’s patch targeting approach
title_short Oral bioavailability enhancement of agomelatine by loading into nanostructured lipid carriers: Peyer’s patch targeting approach
title_full Oral bioavailability enhancement of agomelatine by loading into nanostructured lipid carriers: Peyer’s patch targeting approach
title_fullStr Oral bioavailability enhancement of agomelatine by loading into nanostructured lipid carriers: Peyer’s patch targeting approach
title_full_unstemmed Oral bioavailability enhancement of agomelatine by loading into nanostructured lipid carriers: Peyer’s patch targeting approach
title_sort oral bioavailability enhancement of agomelatine by loading into nanostructured lipid carriers: peyer’s patch targeting approach
publisher Dove Medical Press
publishDate 2018
url https://doaj.org/article/2e1fcfa1c1b54a0d8073a272f35ae2d0
work_keys_str_mv AT prajapatijb oralbioavailabilityenhancementofagomelatinebyloadingintonanostructuredlipidcarrierspeyerrsquospatchtargetingapproach
AT vermasd oralbioavailabilityenhancementofagomelatinebyloadingintonanostructuredlipidcarrierspeyerrsquospatchtargetingapproach
AT patelaa oralbioavailabilityenhancementofagomelatinebyloadingintonanostructuredlipidcarrierspeyerrsquospatchtargetingapproach
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