Accuracy of citrulline, I-FABP and d-lactate in the diagnosis of acute mesenteric ischemia

Abstract Early diagnosis of acute mesenteric ischemia (AMI) remains a clinical challenge, and no biomarker has been consistently validated. We aimed to assess the accuracy of three promising circulating biomarkers for diagnosing AMI—citrulline, intestinal fatty acid-binding protein (I-FABP), and d-l...

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Autores principales:	Alexandre Nuzzo, Kevin Guedj, Sonja Curac, Claude Hercend, Claude Bendavid, Nathalie Gault, Alexy Tran-Dinh, Maxime Ronot, Antonino Nicoletti, Yoram Bouhnik, Yves Castier, Olivier Corcos, Katell Peoc’h, The SURVI (Structure d’URgences Vasculaires Intestinales) Research Group (French Intestinal Stroke Center)
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2e261513e7ad45e681a6aed84f57d559
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spelling	oai:doaj.org-article:2e261513e7ad45e681a6aed84f57d5592021-12-02T15:15:14ZAccuracy of citrulline, I-FABP and d-lactate in the diagnosis of acute mesenteric ischemia10.1038/s41598-021-98012-w2045-2322https://doaj.org/article/2e261513e7ad45e681a6aed84f57d5592021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98012-whttps://doaj.org/toc/2045-2322Abstract Early diagnosis of acute mesenteric ischemia (AMI) remains a clinical challenge, and no biomarker has been consistently validated. We aimed to assess the accuracy of three promising circulating biomarkers for diagnosing AMI—citrulline, intestinal fatty acid-binding protein (I-FABP), and d-lactate. A cross-sectional diagnostic study enrolled AMI patients admitted to the intestinal stroke center and controls with acute abdominal pain of another origin. We included 129 patients—50 AMI and 79 controls. Plasma citrulline concentrations were significantly lower in AMI patients compared to the controls [15.3 μmol/L (12.0–26.0) vs. 23.3 μmol/L (18.3–29.8), p = 0.001]. However, the area under the receiver operating curves (AUROC) for the diagnosis of AMI by Citrulline was low: 0.68 (95% confidence interval = 0.58–0.78). No statistical difference was found in plasma I-FABP and plasma d-lactate concentrations between the AMI and control groups, with an AUROC of 0.44, and 0.40, respectively. In this large cross-sectional study, citrulline, I-FABP, and d-lactate failed to differentiate patients with AMI from patients with acute abdominal pain of another origin. Further research should focus on the discovery of new biomarkers.Alexandre NuzzoKevin GuedjSonja CuracClaude HercendClaude BendavidNathalie GaultAlexy Tran-DinhMaxime RonotAntonino NicolettiYoram BouhnikYves CastierOlivier CorcosKatell Peoc’hThe SURVI (Structure d’URgences Vasculaires Intestinales) Research Group (French Intestinal Stroke Center)Nature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alexandre Nuzzo Kevin Guedj Sonja Curac Claude Hercend Claude Bendavid Nathalie Gault Alexy Tran-Dinh Maxime Ronot Antonino Nicoletti Yoram Bouhnik Yves Castier Olivier Corcos Katell Peoc’h The SURVI (Structure d’URgences Vasculaires Intestinales) Research Group (French Intestinal Stroke Center) Accuracy of citrulline, I-FABP and d-lactate in the diagnosis of acute mesenteric ischemia
description	Abstract Early diagnosis of acute mesenteric ischemia (AMI) remains a clinical challenge, and no biomarker has been consistently validated. We aimed to assess the accuracy of three promising circulating biomarkers for diagnosing AMI—citrulline, intestinal fatty acid-binding protein (I-FABP), and d-lactate. A cross-sectional diagnostic study enrolled AMI patients admitted to the intestinal stroke center and controls with acute abdominal pain of another origin. We included 129 patients—50 AMI and 79 controls. Plasma citrulline concentrations were significantly lower in AMI patients compared to the controls [15.3 μmol/L (12.0–26.0) vs. 23.3 μmol/L (18.3–29.8), p = 0.001]. However, the area under the receiver operating curves (AUROC) for the diagnosis of AMI by Citrulline was low: 0.68 (95% confidence interval = 0.58–0.78). No statistical difference was found in plasma I-FABP and plasma d-lactate concentrations between the AMI and control groups, with an AUROC of 0.44, and 0.40, respectively. In this large cross-sectional study, citrulline, I-FABP, and d-lactate failed to differentiate patients with AMI from patients with acute abdominal pain of another origin. Further research should focus on the discovery of new biomarkers.
format	article
author	Alexandre Nuzzo Kevin Guedj Sonja Curac Claude Hercend Claude Bendavid Nathalie Gault Alexy Tran-Dinh Maxime Ronot Antonino Nicoletti Yoram Bouhnik Yves Castier Olivier Corcos Katell Peoc’h The SURVI (Structure d’URgences Vasculaires Intestinales) Research Group (French Intestinal Stroke Center)
author_facet	Alexandre Nuzzo Kevin Guedj Sonja Curac Claude Hercend Claude Bendavid Nathalie Gault Alexy Tran-Dinh Maxime Ronot Antonino Nicoletti Yoram Bouhnik Yves Castier Olivier Corcos Katell Peoc’h The SURVI (Structure d’URgences Vasculaires Intestinales) Research Group (French Intestinal Stroke Center)
author_sort	Alexandre Nuzzo
title	Accuracy of citrulline, I-FABP and d-lactate in the diagnosis of acute mesenteric ischemia
title_short	Accuracy of citrulline, I-FABP and d-lactate in the diagnosis of acute mesenteric ischemia
title_full	Accuracy of citrulline, I-FABP and d-lactate in the diagnosis of acute mesenteric ischemia
title_fullStr	Accuracy of citrulline, I-FABP and d-lactate in the diagnosis of acute mesenteric ischemia
title_full_unstemmed	Accuracy of citrulline, I-FABP and d-lactate in the diagnosis of acute mesenteric ischemia
title_sort	accuracy of citrulline, i-fabp and d-lactate in the diagnosis of acute mesenteric ischemia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2e261513e7ad45e681a6aed84f57d559
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Accuracy of citrulline, I-FABP and d-lactate in the diagnosis of acute mesenteric ischemia

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