The Great Escape: mRNA Export through the Nuclear Pore Complex

Nuclear export of messenger RNA (mRNA) through the nuclear pore complex (NPC) is an indispensable step to ensure protein translation in the cytoplasm of eukaryotic cells. mRNA is not translocated on its own, but it forms ribonuclear particles (mRNPs) in association with proteins that are crucial for...

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Autor principal:	Paola De Magistris
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	mRNA mRNP NPC nuclear transport nuclear export Mex67/MTR2 Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/2e28186f88ac4aef87557a18c0edbc2f
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spelling	oai:doaj.org-article:2e28186f88ac4aef87557a18c0edbc2f2021-11-11T17:13:13ZThe Great Escape: mRNA Export through the Nuclear Pore Complex10.3390/ijms2221117671422-00671661-6596https://doaj.org/article/2e28186f88ac4aef87557a18c0edbc2f2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11767https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Nuclear export of messenger RNA (mRNA) through the nuclear pore complex (NPC) is an indispensable step to ensure protein translation in the cytoplasm of eukaryotic cells. mRNA is not translocated on its own, but it forms ribonuclear particles (mRNPs) in association with proteins that are crucial for its metabolism, some of which; like Mex67/MTR2-NXF1/NXT1; are key players for its translocation to the cytoplasm. In this review, I will summarize our current body of knowledge on the basic characteristics of mRNA export through the NPC. To be granted passage, the mRNP cargo needs to bind transport receptors, which facilitate the nuclear export. During NPC transport, mRNPs undergo compositional and conformational changes. The interactions between mRNP and the central channel of NPC are described; together with the multiple quality control steps that mRNPs undergo at the different rings of the NPC to ensure only proper export of mature transcripts to the cytoplasm. I conclude by mentioning new opportunities that arise from bottom up approaches for a mechanistic understanding of nuclear export.Paola De MagistrisMDPI AGarticlemRNAmRNPNPCnuclear transportnuclear exportMex67/MTR2Biology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11767, p 11767 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mRNA mRNP NPC nuclear transport nuclear export Mex67/MTR2 Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	mRNA mRNP NPC nuclear transport nuclear export Mex67/MTR2 Biology (General) QH301-705.5 Chemistry QD1-999 Paola De Magistris The Great Escape: mRNA Export through the Nuclear Pore Complex
description	Nuclear export of messenger RNA (mRNA) through the nuclear pore complex (NPC) is an indispensable step to ensure protein translation in the cytoplasm of eukaryotic cells. mRNA is not translocated on its own, but it forms ribonuclear particles (mRNPs) in association with proteins that are crucial for its metabolism, some of which; like Mex67/MTR2-NXF1/NXT1; are key players for its translocation to the cytoplasm. In this review, I will summarize our current body of knowledge on the basic characteristics of mRNA export through the NPC. To be granted passage, the mRNP cargo needs to bind transport receptors, which facilitate the nuclear export. During NPC transport, mRNPs undergo compositional and conformational changes. The interactions between mRNP and the central channel of NPC are described; together with the multiple quality control steps that mRNPs undergo at the different rings of the NPC to ensure only proper export of mature transcripts to the cytoplasm. I conclude by mentioning new opportunities that arise from bottom up approaches for a mechanistic understanding of nuclear export.
format	article
author	Paola De Magistris
author_facet	Paola De Magistris
author_sort	Paola De Magistris
title	The Great Escape: mRNA Export through the Nuclear Pore Complex
title_short	The Great Escape: mRNA Export through the Nuclear Pore Complex
title_full	The Great Escape: mRNA Export through the Nuclear Pore Complex
title_fullStr	The Great Escape: mRNA Export through the Nuclear Pore Complex
title_full_unstemmed	The Great Escape: mRNA Export through the Nuclear Pore Complex
title_sort	great escape: mrna export through the nuclear pore complex
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2e28186f88ac4aef87557a18c0edbc2f
work_keys_str_mv	AT paolademagistris thegreatescapemrnaexportthroughthenuclearporecomplex AT paolademagistris greatescapemrnaexportthroughthenuclearporecomplex
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The Great Escape: mRNA Export through the Nuclear Pore Complex

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