Hair follicle germs containing vascular endothelial cells for hair regenerative medicine

Abstract Hair regenerative medicine has emerged as a promising approach for the treatment of severe hair loss. Recent advances in three-dimensional tissue engineering, such as formation of hair follicle germs (HFGs), have considerably improved hair regeneration after transplantation in animal models...

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Autores principales:	Tatsuto Kageyama, Yang-Sook Chun, Junji Fukuda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2e28f0e4396e49618c6ad62f7259a8b1
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spelling	oai:doaj.org-article:2e28f0e4396e49618c6ad62f7259a8b12021-12-02T14:01:38ZHair follicle germs containing vascular endothelial cells for hair regenerative medicine10.1038/s41598-020-79722-z2045-2322https://doaj.org/article/2e28f0e4396e49618c6ad62f7259a8b12021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79722-zhttps://doaj.org/toc/2045-2322Abstract Hair regenerative medicine has emerged as a promising approach for the treatment of severe hair loss. Recent advances in three-dimensional tissue engineering, such as formation of hair follicle germs (HFGs), have considerably improved hair regeneration after transplantation in animal models. Here, we proposed an approach for fabricating HFGs containing vascular endothelial cells. Epithelial, dermal papilla, and vascular endothelial cells initially formed a single aggregate, which subsequently became a dumbbell-shaped HFG, wherein the vascular endothelial cells localized in the region of dermal papilla cells. The HFGs containing vascular endothelial cells exhibited higher expression of hair morphogenesis-related genes in vitro, along with higher levels of hair shaft regeneration upon transplantation to the dorsal side of nude mice, than those without vascular endothelial cells. The generated hair follicles represented functional characteristics, such as piloerection, as well as morphological characteristics comparable to those of natural hair shafts. This approach may provide a promising strategy for fabricating tissue grafts with higher hair inductivity for hair regenerative medicine.Tatsuto KageyamaYang-Sook ChunJunji FukudaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tatsuto Kageyama Yang-Sook Chun Junji Fukuda Hair follicle germs containing vascular endothelial cells for hair regenerative medicine
description	Abstract Hair regenerative medicine has emerged as a promising approach for the treatment of severe hair loss. Recent advances in three-dimensional tissue engineering, such as formation of hair follicle germs (HFGs), have considerably improved hair regeneration after transplantation in animal models. Here, we proposed an approach for fabricating HFGs containing vascular endothelial cells. Epithelial, dermal papilla, and vascular endothelial cells initially formed a single aggregate, which subsequently became a dumbbell-shaped HFG, wherein the vascular endothelial cells localized in the region of dermal papilla cells. The HFGs containing vascular endothelial cells exhibited higher expression of hair morphogenesis-related genes in vitro, along with higher levels of hair shaft regeneration upon transplantation to the dorsal side of nude mice, than those without vascular endothelial cells. The generated hair follicles represented functional characteristics, such as piloerection, as well as morphological characteristics comparable to those of natural hair shafts. This approach may provide a promising strategy for fabricating tissue grafts with higher hair inductivity for hair regenerative medicine.
format	article
author	Tatsuto Kageyama Yang-Sook Chun Junji Fukuda
author_facet	Tatsuto Kageyama Yang-Sook Chun Junji Fukuda
author_sort	Tatsuto Kageyama
title	Hair follicle germs containing vascular endothelial cells for hair regenerative medicine
title_short	Hair follicle germs containing vascular endothelial cells for hair regenerative medicine
title_full	Hair follicle germs containing vascular endothelial cells for hair regenerative medicine
title_fullStr	Hair follicle germs containing vascular endothelial cells for hair regenerative medicine
title_full_unstemmed	Hair follicle germs containing vascular endothelial cells for hair regenerative medicine
title_sort	hair follicle germs containing vascular endothelial cells for hair regenerative medicine
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2e28f0e4396e49618c6ad62f7259a8b1
work_keys_str_mv	AT tatsutokageyama hairfolliclegermscontainingvascularendothelialcellsforhairregenerativemedicine AT yangsookchun hairfolliclegermscontainingvascularendothelialcellsforhairregenerativemedicine AT junjifukuda hairfolliclegermscontainingvascularendothelialcellsforhairregenerativemedicine
_version_	1718392129895530496

Hair follicle germs containing vascular endothelial cells for hair regenerative medicine

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