Neoechinulins: Molecular, cellular, and functional attributes as promising therapeutics against cancer and other human diseases

Neoechinulins are fungal and plant-derived chemicals extracted from Microsporum sp., Eurotium rubrum, Aspergillus sp., etc. Two analogues of neoechinulin, i.e., A and B, exerted extensive pharmacological properties described in this review. Neoechinulin is an indole alkaloid and has a double bond be...

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Autores principales:	Sicon Mitra, Uttpal Anand, Rupa Sanyal, Niraj Kumar Jha, Tapan Behl, Avinash Mundhra, Arabinda Ghosh, Radha, Manoj Kumar, Jarosław Proćków, Abhijit Dey
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Neoechinulin A Neoechinulin B Phytochemical Cyto-protection Nitrosative Anti-depressant Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/2e2a99a5439147179eb883ed90c5742c
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spelling	oai:doaj.org-article:2e2a99a5439147179eb883ed90c5742c2021-11-04T04:26:14ZNeoechinulins: Molecular, cellular, and functional attributes as promising therapeutics against cancer and other human diseases0753-332210.1016/j.biopha.2021.112378https://doaj.org/article/2e2a99a5439147179eb883ed90c5742c2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221011628https://doaj.org/toc/0753-3322Neoechinulins are fungal and plant-derived chemicals extracted from Microsporum sp., Eurotium rubrum, Aspergillus sp., etc. Two analogues of neoechinulin, i.e., A and B, exerted extensive pharmacological properties described in this review. Neoechinulin is an indole alkaloid and has a double bond between C8/C9, which tends to contribute to its cytoprotective nature. Neoechinulin A exhibits protection to PC12 cells against nitrosative stress via increasing NAD(P)H reserve capacity and decreasing cellular GSH levels. It also confers protection via rescuing PC12 cells from rotenone-induced stress by lowering LDH leakage. This compound has great positive potential against neurodegenerative diseases by inhibiting SIN-1 induced cell death in neuronal cells. Together with these, neoechinulin A tends to inhibit Aβ42-induced microglial activation and confers protection against neuroinflammation. Alongside, it also inhibits cervical cancer cells by caspase-dependent apoptosis and via upregulation of apoptosis inducing genes like Bax, it suppresses LPS-induced inflammation in RAW264.7 macrophages and acts as an antidepressant. Whereas, another analogue, Neoechinulin B tends to interfere with the cellular mechanism thereby, inhibiting the entry of influenza A virus and it targets Liver X receptor (LXR) and decreases the infection rate of Hepatitis C. The present review describes the pharmaceutical properties of neoechinulins with notes on their molecular, cellular, and functional basis and their therapeutic properties.Sicon MitraUttpal AnandRupa SanyalNiraj Kumar JhaTapan BehlAvinash MundhraArabinda Ghosh RadhaManoj KumarJarosław ProćkówAbhijit DeyElsevierarticleNeoechinulin ANeoechinulin BPhytochemicalCyto-protectionNitrosativeAnti-depressantTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112378- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoechinulin A Neoechinulin B Phytochemical Cyto-protection Nitrosative Anti-depressant Therapeutics. Pharmacology RM1-950
spellingShingle	Neoechinulin A Neoechinulin B Phytochemical Cyto-protection Nitrosative Anti-depressant Therapeutics. Pharmacology RM1-950 Sicon Mitra Uttpal Anand Rupa Sanyal Niraj Kumar Jha Tapan Behl Avinash Mundhra Arabinda Ghosh Radha Manoj Kumar Jarosław Proćków Abhijit Dey Neoechinulins: Molecular, cellular, and functional attributes as promising therapeutics against cancer and other human diseases
description	Neoechinulins are fungal and plant-derived chemicals extracted from Microsporum sp., Eurotium rubrum, Aspergillus sp., etc. Two analogues of neoechinulin, i.e., A and B, exerted extensive pharmacological properties described in this review. Neoechinulin is an indole alkaloid and has a double bond between C8/C9, which tends to contribute to its cytoprotective nature. Neoechinulin A exhibits protection to PC12 cells against nitrosative stress via increasing NAD(P)H reserve capacity and decreasing cellular GSH levels. It also confers protection via rescuing PC12 cells from rotenone-induced stress by lowering LDH leakage. This compound has great positive potential against neurodegenerative diseases by inhibiting SIN-1 induced cell death in neuronal cells. Together with these, neoechinulin A tends to inhibit Aβ42-induced microglial activation and confers protection against neuroinflammation. Alongside, it also inhibits cervical cancer cells by caspase-dependent apoptosis and via upregulation of apoptosis inducing genes like Bax, it suppresses LPS-induced inflammation in RAW264.7 macrophages and acts as an antidepressant. Whereas, another analogue, Neoechinulin B tends to interfere with the cellular mechanism thereby, inhibiting the entry of influenza A virus and it targets Liver X receptor (LXR) and decreases the infection rate of Hepatitis C. The present review describes the pharmaceutical properties of neoechinulins with notes on their molecular, cellular, and functional basis and their therapeutic properties.
format	article
author	Sicon Mitra Uttpal Anand Rupa Sanyal Niraj Kumar Jha Tapan Behl Avinash Mundhra Arabinda Ghosh Radha Manoj Kumar Jarosław Proćków Abhijit Dey
author_facet	Sicon Mitra Uttpal Anand Rupa Sanyal Niraj Kumar Jha Tapan Behl Avinash Mundhra Arabinda Ghosh Radha Manoj Kumar Jarosław Proćków Abhijit Dey
author_sort	Sicon Mitra
title	Neoechinulins: Molecular, cellular, and functional attributes as promising therapeutics against cancer and other human diseases
title_short	Neoechinulins: Molecular, cellular, and functional attributes as promising therapeutics against cancer and other human diseases
title_full	Neoechinulins: Molecular, cellular, and functional attributes as promising therapeutics against cancer and other human diseases
title_fullStr	Neoechinulins: Molecular, cellular, and functional attributes as promising therapeutics against cancer and other human diseases
title_full_unstemmed	Neoechinulins: Molecular, cellular, and functional attributes as promising therapeutics against cancer and other human diseases
title_sort	neoechinulins: molecular, cellular, and functional attributes as promising therapeutics against cancer and other human diseases
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/2e2a99a5439147179eb883ed90c5742c
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Neoechinulins: Molecular, cellular, and functional attributes as promising therapeutics against cancer and other human diseases

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