IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis

IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis

Dimethyl fumarate (DMF) is a therapy for multiple sclerosis (MS) with undetermined mechanism of action. Here the authors find that clinical response to DMF associates with decrease in IL-17-producing CD8+ T cells (Tc17), delineate molecular pathways involved, and show that DMF suppresses Tc17 pathog...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Christina Lückel, Felix Picard, Hartmann Raifer, Lucia Campos Carrascosa, Anna Guralnik, Yajuan Zhang, Matthias Klein, Stefan Bittner, Falk Steffen, Sonja Moos, Federico Marini, Renee Gloury, Florian C. Kurschus, Ying-Yin Chao, Wilhelm Bertrams, Veronika Sexl, Bernd Schmeck, Lynn Bonetti, Melanie Grusdat, Michael Lohoff, Christina E. Zielinski, Frauke Zipp, Axel Kallies, Dirk Brenner, Michael Berger, Tobias Bopp, Björn Tackenberg, Magdalena Huber
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/2e2f0c2356834c5db881aabfe09b997c
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:2e2f0c2356834c5db881aabfe09b997c
record_format dspace
spelling oai:doaj.org-article:2e2f0c2356834c5db881aabfe09b997c2021-12-02T15:36:02ZIL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis10.1038/s41467-019-13731-z2041-1723https://doaj.org/article/2e2f0c2356834c5db881aabfe09b997c2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13731-zhttps://doaj.org/toc/2041-1723Dimethyl fumarate (DMF) is a therapy for multiple sclerosis (MS) with undetermined mechanism of action. Here the authors find that clinical response to DMF associates with decrease in IL-17-producing CD8+ T cells (Tc17), delineate molecular pathways involved, and show that DMF suppresses Tc17 pathogenicity in a mouse model of MS.Christina LückelFelix PicardHartmann RaiferLucia Campos CarrascosaAnna GuralnikYajuan ZhangMatthias KleinStefan BittnerFalk SteffenSonja MoosFederico MariniRenee GlouryFlorian C. KurschusYing-Yin ChaoWilhelm BertramsVeronika SexlBernd SchmeckLynn BonettiMelanie GrusdatMichael LohoffChristina E. ZielinskiFrauke ZippAxel KalliesDirk BrennerMichael BergerTobias BoppBjörn TackenbergMagdalena HuberNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Christina Lückel
Felix Picard
Hartmann Raifer
Lucia Campos Carrascosa
Anna Guralnik
Yajuan Zhang
Matthias Klein
Stefan Bittner
Falk Steffen
Sonja Moos
Federico Marini
Renee Gloury
Florian C. Kurschus
Ying-Yin Chao
Wilhelm Bertrams
Veronika Sexl
Bernd Schmeck
Lynn Bonetti
Melanie Grusdat
Michael Lohoff
Christina E. Zielinski
Frauke Zipp
Axel Kallies
Dirk Brenner
Michael Berger
Tobias Bopp
Björn Tackenberg
Magdalena Huber
IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis
description Dimethyl fumarate (DMF) is a therapy for multiple sclerosis (MS) with undetermined mechanism of action. Here the authors find that clinical response to DMF associates with decrease in IL-17-producing CD8+ T cells (Tc17), delineate molecular pathways involved, and show that DMF suppresses Tc17 pathogenicity in a mouse model of MS.
format article
author Christina Lückel
Felix Picard
Hartmann Raifer
Lucia Campos Carrascosa
Anna Guralnik
Yajuan Zhang
Matthias Klein
Stefan Bittner
Falk Steffen
Sonja Moos
Federico Marini
Renee Gloury
Florian C. Kurschus
Ying-Yin Chao
Wilhelm Bertrams
Veronika Sexl
Bernd Schmeck
Lynn Bonetti
Melanie Grusdat
Michael Lohoff
Christina E. Zielinski
Frauke Zipp
Axel Kallies
Dirk Brenner
Michael Berger
Tobias Bopp
Björn Tackenberg
Magdalena Huber
author_facet Christina Lückel
Felix Picard
Hartmann Raifer
Lucia Campos Carrascosa
Anna Guralnik
Yajuan Zhang
Matthias Klein
Stefan Bittner
Falk Steffen
Sonja Moos
Federico Marini
Renee Gloury
Florian C. Kurschus
Ying-Yin Chao
Wilhelm Bertrams
Veronika Sexl
Bernd Schmeck
Lynn Bonetti
Melanie Grusdat
Michael Lohoff
Christina E. Zielinski
Frauke Zipp
Axel Kallies
Dirk Brenner
Michael Berger
Tobias Bopp
Björn Tackenberg
Magdalena Huber
author_sort Christina Lückel
title IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis
title_short IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis
title_full IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis
title_fullStr IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis
title_full_unstemmed IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis
title_sort il-17+ cd8+ t cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/2e2f0c2356834c5db881aabfe09b997c
work_keys_str_mv AT christinaluckel il17cd8tcellsuppressionbydimethylfumarateassociateswithclinicalresponseinmultiplesclerosis
AT felixpicard il17cd8tcellsuppressionbydimethylfumarateassociateswithclinicalresponseinmultiplesclerosis
AT hartmannraifer il17cd8tcellsuppressionbydimethylfumarateassociateswithclinicalresponseinmultiplesclerosis
AT luciacamposcarrascosa il17cd8tcellsuppressionbydimethylfumarateassociateswithclinicalresponseinmultiplesclerosis
AT annaguralnik il17cd8tcellsuppressionbydimethylfumarateassociateswithclinicalresponseinmultiplesclerosis
AT yajuanzhang il17cd8tcellsuppressionbydimethylfumarateassociateswithclinicalresponseinmultiplesclerosis
AT matthiasklein il17cd8tcellsuppressionbydimethylfumarateassociateswithclinicalresponseinmultiplesclerosis
AT stefanbittner il17cd8tcellsuppressionbydimethylfumarateassociateswithclinicalresponseinmultiplesclerosis
AT falksteffen il17cd8tcellsuppressionbydimethylfumarateassociateswithclinicalresponseinmultiplesclerosis
AT sonjamoos il17cd8tcellsuppressionbydimethylfumarateassociateswithclinicalresponseinmultiplesclerosis
AT federicomarini il17cd8tcellsuppressionbydimethylfumarateassociateswithclinicalresponseinmultiplesclerosis
AT reneegloury il17cd8tcellsuppressionbydimethylfumarateassociateswithclinicalresponseinmultiplesclerosis
AT florianckurschus il17cd8tcellsuppressionbydimethylfumarateassociateswithclinicalresponseinmultiplesclerosis
AT yingyinchao il17cd8tcellsuppressionbydimethylfumarateassociateswithclinicalresponseinmultiplesclerosis
AT wilhelmbertrams il17cd8tcellsuppressionbydimethylfumarateassociateswithclinicalresponseinmultiplesclerosis
AT veronikasexl il17cd8tcellsuppressionbydimethylfumarateassociateswithclinicalresponseinmultiplesclerosis
AT berndschmeck il17cd8tcellsuppressionbydimethylfumarateassociateswithclinicalresponseinmultiplesclerosis
AT lynnbonetti il17cd8tcellsuppressionbydimethylfumarateassociateswithclinicalresponseinmultiplesclerosis
AT melaniegrusdat il17cd8tcellsuppressionbydimethylfumarateassociateswithclinicalresponseinmultiplesclerosis
AT michaellohoff il17cd8tcellsuppressionbydimethylfumarateassociateswithclinicalresponseinmultiplesclerosis
AT christinaezielinski il17cd8tcellsuppressionbydimethylfumarateassociateswithclinicalresponseinmultiplesclerosis
AT fraukezipp il17cd8tcellsuppressionbydimethylfumarateassociateswithclinicalresponseinmultiplesclerosis
AT axelkallies il17cd8tcellsuppressionbydimethylfumarateassociateswithclinicalresponseinmultiplesclerosis
AT dirkbrenner il17cd8tcellsuppressionbydimethylfumarateassociateswithclinicalresponseinmultiplesclerosis
AT michaelberger il17cd8tcellsuppressionbydimethylfumarateassociateswithclinicalresponseinmultiplesclerosis
AT tobiasbopp il17cd8tcellsuppressionbydimethylfumarateassociateswithclinicalresponseinmultiplesclerosis
AT bjorntackenberg il17cd8tcellsuppressionbydimethylfumarateassociateswithclinicalresponseinmultiplesclerosis
AT magdalenahuber il17cd8tcellsuppressionbydimethylfumarateassociateswithclinicalresponseinmultiplesclerosis
_version_ 1718386344422539264

Ejemplares similares