Antibiotic prescribing in Danish general practice in the elderly population from 2010 to 2017

Objective This study aimed to describe prescription of antibiotics to the elderly population in general practice in Denmark from 2010–2017. Design This is a national register-based observational study. Setting General practice, Denmark Main outcome measure The main outcome measure was prescriptions/...

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Autores principales:	Maria Louise Veimer Jensen, Rune Munck Aabenhus, Barbara Juliane Holzknecht, Lars Bjerrum, Jette Nygaard Jensen, Volkert Siersma, Gloria Córdoba
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	general practice antibiotic prescriptions prescriptions patterns elderly population aged Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/2e3257aaec524d61bccb2002ddbebfe5
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spelling	oai:doaj.org-article:2e3257aaec524d61bccb2002ddbebfe52021-11-26T11:19:46ZAntibiotic prescribing in Danish general practice in the elderly population from 2010 to 20170281-34321502-772410.1080/02813432.2021.2004754https://doaj.org/article/2e3257aaec524d61bccb2002ddbebfe52021-11-01T00:00:00Zhttp://dx.doi.org/10.1080/02813432.2021.2004754https://doaj.org/toc/0281-3432https://doaj.org/toc/1502-7724Objective This study aimed to describe prescription of antibiotics to the elderly population in general practice in Denmark from 2010–2017. Design This is a national register-based observational study. Setting General practice, Denmark Main outcome measure The main outcome measure was prescriptions/1,000 inhabitants/day (PrID) in relation to year, age and sex, indication, and antibiotic agent. Subjects In this study, we included inhabitants of Denmark, ≥65 years of age between 01st July 2010–30th June 2017. Results A total of 5,168,878 prescriptions were included in the study. Antibiotic prescriptions decreased from 2.2 PrID to 1.7 (-26.9%, CI95% [-31.1;-22.4]) PrID during the study. The decrease in PrID was most noticeable among 65–74-year-olds (-25%). The ≥85-year-olds were exposed to twice as many PrID than the 65–74-year-olds, but only accounted for 20% of the total use. Urinary tract infection (UTI) was the most common indication for antibiotic prescription and increased with advancing age. The most commonly prescribed antibiotics were pivmecillinam and phenoxymethylpenicillin. Prescribing with no informative indication was present in one third of all cases. Conclusion The prescription of antibiotics in the elderly population in general practice decreased from 2010 to 2017. The oldest age group was exposed twice as frequently to antibiotic prescriptions as the 65–74-year-olds. The smallest reduction was observed for the ≥85-year-olds, suggesting targeting interventions at this group.Key Points High antibiotic use among elderly is well known and studies indicate mis- and overuse within this population. Our study shows. The prescription rate is decreasing within all age groups of the elderly population. The ≥85-year-olds receive twice as many prescriptions/1000/day as the 65–74-years-olds.Maria Louise Veimer JensenRune Munck AabenhusBarbara Juliane HolzknechtLars BjerrumJette Nygaard JensenVolkert SiersmaGloria CórdobaTaylor & Francis Grouparticlegeneral practiceantibiotic prescriptionsprescriptions patternselderly populationagedPublic aspects of medicineRA1-1270ENScandinavian Journal of Primary Health Care, Vol 0, Iss 0, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	general practice antibiotic prescriptions prescriptions patterns elderly population aged Public aspects of medicine RA1-1270
spellingShingle	general practice antibiotic prescriptions prescriptions patterns elderly population aged Public aspects of medicine RA1-1270 Maria Louise Veimer Jensen Rune Munck Aabenhus Barbara Juliane Holzknecht Lars Bjerrum Jette Nygaard Jensen Volkert Siersma Gloria Córdoba Antibiotic prescribing in Danish general practice in the elderly population from 2010 to 2017
description	Objective This study aimed to describe prescription of antibiotics to the elderly population in general practice in Denmark from 2010–2017. Design This is a national register-based observational study. Setting General practice, Denmark Main outcome measure The main outcome measure was prescriptions/1,000 inhabitants/day (PrID) in relation to year, age and sex, indication, and antibiotic agent. Subjects In this study, we included inhabitants of Denmark, ≥65 years of age between 01st July 2010–30th June 2017. Results A total of 5,168,878 prescriptions were included in the study. Antibiotic prescriptions decreased from 2.2 PrID to 1.7 (-26.9%, CI95% [-31.1;-22.4]) PrID during the study. The decrease in PrID was most noticeable among 65–74-year-olds (-25%). The ≥85-year-olds were exposed to twice as many PrID than the 65–74-year-olds, but only accounted for 20% of the total use. Urinary tract infection (UTI) was the most common indication for antibiotic prescription and increased with advancing age. The most commonly prescribed antibiotics were pivmecillinam and phenoxymethylpenicillin. Prescribing with no informative indication was present in one third of all cases. Conclusion The prescription of antibiotics in the elderly population in general practice decreased from 2010 to 2017. The oldest age group was exposed twice as frequently to antibiotic prescriptions as the 65–74-year-olds. The smallest reduction was observed for the ≥85-year-olds, suggesting targeting interventions at this group.Key Points High antibiotic use among elderly is well known and studies indicate mis- and overuse within this population. Our study shows. The prescription rate is decreasing within all age groups of the elderly population. The ≥85-year-olds receive twice as many prescriptions/1000/day as the 65–74-years-olds.
format	article
author	Maria Louise Veimer Jensen Rune Munck Aabenhus Barbara Juliane Holzknecht Lars Bjerrum Jette Nygaard Jensen Volkert Siersma Gloria Córdoba
author_facet	Maria Louise Veimer Jensen Rune Munck Aabenhus Barbara Juliane Holzknecht Lars Bjerrum Jette Nygaard Jensen Volkert Siersma Gloria Córdoba
author_sort	Maria Louise Veimer Jensen
title	Antibiotic prescribing in Danish general practice in the elderly population from 2010 to 2017
title_short	Antibiotic prescribing in Danish general practice in the elderly population from 2010 to 2017
title_full	Antibiotic prescribing in Danish general practice in the elderly population from 2010 to 2017
title_fullStr	Antibiotic prescribing in Danish general practice in the elderly population from 2010 to 2017
title_full_unstemmed	Antibiotic prescribing in Danish general practice in the elderly population from 2010 to 2017
title_sort	antibiotic prescribing in danish general practice in the elderly population from 2010 to 2017
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/2e3257aaec524d61bccb2002ddbebfe5
work_keys_str_mv	AT marialouiseveimerjensen antibioticprescribingindanishgeneralpracticeintheelderlypopulationfrom2010to2017 AT runemunckaabenhus antibioticprescribingindanishgeneralpracticeintheelderlypopulationfrom2010to2017 AT barbarajulianeholzknecht antibioticprescribingindanishgeneralpracticeintheelderlypopulationfrom2010to2017 AT larsbjerrum antibioticprescribingindanishgeneralpracticeintheelderlypopulationfrom2010to2017 AT jettenygaardjensen antibioticprescribingindanishgeneralpracticeintheelderlypopulationfrom2010to2017 AT volkertsiersma antibioticprescribingindanishgeneralpracticeintheelderlypopulationfrom2010to2017 AT gloriacordoba antibioticprescribingindanishgeneralpracticeintheelderlypopulationfrom2010to2017
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Antibiotic prescribing in Danish general practice in the elderly population from 2010 to 2017

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