Expression of IDE and PITRM1 genes in ERN1 knockdown U87 glioma cells: effect of hypoxia and glucose deprivation
Objective. The aim of the present investigation was to study the expression of genes encoding polyfunctional proteins insulinase (insulin degrading enzyme, IDE) and pitrilysin metallopeptidase 1 (PITRM1) in U87 glioma cells in response to inhibition of endoplasmic reticulum stress signaling mediated...
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2020
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oai:doaj.org-article:2e32ed13155943aabe06d3720f9c08572021-12-02T16:40:25ZExpression of IDE and PITRM1 genes in ERN1 knockdown U87 glioma cells: effect of hypoxia and glucose deprivation1336-032910.2478/enr-2020-0021https://doaj.org/article/2e32ed13155943aabe06d3720f9c08572020-07-01T00:00:00Zhttps://doi.org/10.2478/enr-2020-0021https://doaj.org/toc/1336-0329Objective. The aim of the present investigation was to study the expression of genes encoding polyfunctional proteins insulinase (insulin degrading enzyme, IDE) and pitrilysin metallopeptidase 1 (PITRM1) in U87 glioma cells in response to inhibition of endoplasmic reticulum stress signaling mediated by ERN1/IRE1 (endoplasmic reticulum to nucleus signaling 1) for evaluation of their possible significance in the control of metabolism through ERN1 signaling as well as hypoxia, glucose and glutamine deprivations.Minchenko Dmytro O.Khita Olena O.Tsymbal Dariia O.Danilovskyi Serhij V.Rudnytska Olha V.Halkin Oleh V.Kryvdiuk Iryna V.Smeshkova Maria V.Yakymchuk Mykhailo M.Bezrodnyi Borys H.Minchenko Oleksandr H.Sciendoarticleern1 knockdownidepitrm1mrna expressionmicrornahypoxiaglucose deprivationu87 glioma cellsDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Regulations, Vol 54, Iss 3, Pp 183-195 (2020) |
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DOAJ |
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DOAJ |
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EN |
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ern1 knockdown ide pitrm1 mrna expression microrna hypoxia glucose deprivation u87 glioma cells Diseases of the endocrine glands. Clinical endocrinology RC648-665 |
| spellingShingle |
ern1 knockdown ide pitrm1 mrna expression microrna hypoxia glucose deprivation u87 glioma cells Diseases of the endocrine glands. Clinical endocrinology RC648-665 Minchenko Dmytro O. Khita Olena O. Tsymbal Dariia O. Danilovskyi Serhij V. Rudnytska Olha V. Halkin Oleh V. Kryvdiuk Iryna V. Smeshkova Maria V. Yakymchuk Mykhailo M. Bezrodnyi Borys H. Minchenko Oleksandr H. Expression of IDE and PITRM1 genes in ERN1 knockdown U87 glioma cells: effect of hypoxia and glucose deprivation |
| description |
Objective. The aim of the present investigation was to study the expression of genes encoding polyfunctional proteins insulinase (insulin degrading enzyme, IDE) and pitrilysin metallopeptidase 1 (PITRM1) in U87 glioma cells in response to inhibition of endoplasmic reticulum stress signaling mediated by ERN1/IRE1 (endoplasmic reticulum to nucleus signaling 1) for evaluation of their possible significance in the control of metabolism through ERN1 signaling as well as hypoxia, glucose and glutamine deprivations. |
| format |
article |
| author |
Minchenko Dmytro O. Khita Olena O. Tsymbal Dariia O. Danilovskyi Serhij V. Rudnytska Olha V. Halkin Oleh V. Kryvdiuk Iryna V. Smeshkova Maria V. Yakymchuk Mykhailo M. Bezrodnyi Borys H. Minchenko Oleksandr H. |
| author_facet |
Minchenko Dmytro O. Khita Olena O. Tsymbal Dariia O. Danilovskyi Serhij V. Rudnytska Olha V. Halkin Oleh V. Kryvdiuk Iryna V. Smeshkova Maria V. Yakymchuk Mykhailo M. Bezrodnyi Borys H. Minchenko Oleksandr H. |
| author_sort |
Minchenko Dmytro O. |
| title |
Expression of IDE and PITRM1 genes in ERN1 knockdown U87 glioma cells: effect of hypoxia and glucose deprivation |
| title_short |
Expression of IDE and PITRM1 genes in ERN1 knockdown U87 glioma cells: effect of hypoxia and glucose deprivation |
| title_full |
Expression of IDE and PITRM1 genes in ERN1 knockdown U87 glioma cells: effect of hypoxia and glucose deprivation |
| title_fullStr |
Expression of IDE and PITRM1 genes in ERN1 knockdown U87 glioma cells: effect of hypoxia and glucose deprivation |
| title_full_unstemmed |
Expression of IDE and PITRM1 genes in ERN1 knockdown U87 glioma cells: effect of hypoxia and glucose deprivation |
| title_sort |
expression of ide and pitrm1 genes in ern1 knockdown u87 glioma cells: effect of hypoxia and glucose deprivation |
| publisher |
Sciendo |
| publishDate |
2020 |
| url |
https://doaj.org/article/2e32ed13155943aabe06d3720f9c0857 |
| work_keys_str_mv |
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