Risk Factors for Drug Resistance in Epileptic Children with Age of Onset above Five Years: A Case-Control Study

Background. Children with epilepsy with onset above five years encompass distinct epidemiological and clinical characteristics that may have specific risk factors for resistance to antiseizure medications (ASMs). Studies on this age group are limited. Purpose. To identify risk factors for drug resis...

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Autores principales:	Irawan Mangunatmadja, Raden Muhammad Indra, Dwi Putro Widodo, Achmad Rafli
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/2e35f349ebc04e4c9da92127b185f92e
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spelling	oai:doaj.org-article:2e35f349ebc04e4c9da92127b185f92e2021-11-22T01:11:27ZRisk Factors for Drug Resistance in Epileptic Children with Age of Onset above Five Years: A Case-Control Study1875-858410.1155/2021/9092824https://doaj.org/article/2e35f349ebc04e4c9da92127b185f92e2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/9092824https://doaj.org/toc/1875-8584Background. Children with epilepsy with onset above five years encompass distinct epidemiological and clinical characteristics that may have specific risk factors for resistance to antiseizure medications (ASMs). Studies on this age group are limited. Purpose. To identify risk factors for drug resistance in children with epilepsy with the age of onset above five years. Methods. A case-control study was conducted on children with epilepsy with the age of onset above five years visiting the Pediatric Neurology Clinic of Cipto Mangunkusumo and Mohammad Hoesin Hospital between September 2015 and August 2016. Cases consisted of drug-resistant children while control consisted of drug-responsive children according to 2010 ILAE classification. Risk factors studied include onset, number of seizures, illness duration before treatment, cause, seizure type, status epilepticus, initial and evolution of EEG, brain imaging, and initial treatment response. Results. Thirty-two pairs of children were included in the study. After logistic regression analysis, symptomatic etiology and failure to achieve early response to treatment were found to be associated with drug resistance with adjusted OR of 84.71 (95% CI: 5.18-1359.15) and 72.55 (95% CI: 7.08-743.85), respectively. Conclusion. Poor initial response to ASM and symptomatic etiology are independent risk factors for drug resistance in children with epilepsy with the age of onset above five years.Irawan MangunatmadjaRaden Muhammad IndraDwi Putro WidodoAchmad RafliHindawi LimitedarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBehavioural Neurology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Irawan Mangunatmadja Raden Muhammad Indra Dwi Putro Widodo Achmad Rafli Risk Factors for Drug Resistance in Epileptic Children with Age of Onset above Five Years: A Case-Control Study
description	Background. Children with epilepsy with onset above five years encompass distinct epidemiological and clinical characteristics that may have specific risk factors for resistance to antiseizure medications (ASMs). Studies on this age group are limited. Purpose. To identify risk factors for drug resistance in children with epilepsy with the age of onset above five years. Methods. A case-control study was conducted on children with epilepsy with the age of onset above five years visiting the Pediatric Neurology Clinic of Cipto Mangunkusumo and Mohammad Hoesin Hospital between September 2015 and August 2016. Cases consisted of drug-resistant children while control consisted of drug-responsive children according to 2010 ILAE classification. Risk factors studied include onset, number of seizures, illness duration before treatment, cause, seizure type, status epilepticus, initial and evolution of EEG, brain imaging, and initial treatment response. Results. Thirty-two pairs of children were included in the study. After logistic regression analysis, symptomatic etiology and failure to achieve early response to treatment were found to be associated with drug resistance with adjusted OR of 84.71 (95% CI: 5.18-1359.15) and 72.55 (95% CI: 7.08-743.85), respectively. Conclusion. Poor initial response to ASM and symptomatic etiology are independent risk factors for drug resistance in children with epilepsy with the age of onset above five years.
format	article
author	Irawan Mangunatmadja Raden Muhammad Indra Dwi Putro Widodo Achmad Rafli
author_facet	Irawan Mangunatmadja Raden Muhammad Indra Dwi Putro Widodo Achmad Rafli
author_sort	Irawan Mangunatmadja
title	Risk Factors for Drug Resistance in Epileptic Children with Age of Onset above Five Years: A Case-Control Study
title_short	Risk Factors for Drug Resistance in Epileptic Children with Age of Onset above Five Years: A Case-Control Study
title_full	Risk Factors for Drug Resistance in Epileptic Children with Age of Onset above Five Years: A Case-Control Study
title_fullStr	Risk Factors for Drug Resistance in Epileptic Children with Age of Onset above Five Years: A Case-Control Study
title_full_unstemmed	Risk Factors for Drug Resistance in Epileptic Children with Age of Onset above Five Years: A Case-Control Study
title_sort	risk factors for drug resistance in epileptic children with age of onset above five years: a case-control study
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/2e35f349ebc04e4c9da92127b185f92e
work_keys_str_mv	AT irawanmangunatmadja riskfactorsfordrugresistanceinepilepticchildrenwithageofonsetabovefiveyearsacasecontrolstudy AT radenmuhammadindra riskfactorsfordrugresistanceinepilepticchildrenwithageofonsetabovefiveyearsacasecontrolstudy AT dwiputrowidodo riskfactorsfordrugresistanceinepilepticchildrenwithageofonsetabovefiveyearsacasecontrolstudy AT achmadrafli riskfactorsfordrugresistanceinepilepticchildrenwithageofonsetabovefiveyearsacasecontrolstudy
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Risk Factors for Drug Resistance in Epileptic Children with Age of Onset above Five Years: A Case-Control Study

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