Anti-Müllerian Hormone in Pathogenesis, Diagnostic and Treatment of PCOS

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among reproductive-aged women. It is characterized by chronic anovulation, hyperandrogenism, and the presence of polycystic ovary in ultrasound examination. PCOS is specified by an increased number of follicles at all growing sta...

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Autores principales:	Ewa Rudnicka, Michał Kunicki, Anna Calik-Ksepka, Katarzyna Suchta, Anna Duszewska, Katarzyna Smolarczyk, Roman Smolarczyk
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	AMH PCOS hyperandrogenism Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/2e3a546ede3f41e0a171a4b05ae83f69
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spelling	oai:doaj.org-article:2e3a546ede3f41e0a171a4b05ae83f692021-11-25T17:57:21ZAnti-Müllerian Hormone in Pathogenesis, Diagnostic and Treatment of PCOS10.3390/ijms2222125071422-00671661-6596https://doaj.org/article/2e3a546ede3f41e0a171a4b05ae83f692021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12507https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among reproductive-aged women. It is characterized by chronic anovulation, hyperandrogenism, and the presence of polycystic ovary in ultrasound examination. PCOS is specified by an increased number of follicles at all growing stages, mainly seen in the preantral and small antral follicles and an increased serum level of Anti-Müllerian Hormone (AMH). Because of the strong correlation between circulating AMH levels and antral follicle count on ultrasound, Anti-Müllerian Hormone has been proposed as an alternative marker of ovulatory dysfunction in PCOS. However, the results from the current literature are not homogeneous, and the specific threshold of AMH in PCOS and PCOM is, therefore, very challenging. This review aims to update the current knowledge about AMH, the pathophysiology of AMH in the pathogenesis of PCOS, and the role of Anti-Müllerian Hormone in the treatment of this syndrome.Ewa RudnickaMichał KunickiAnna Calik-KsepkaKatarzyna SuchtaAnna DuszewskaKatarzyna SmolarczykRoman SmolarczykMDPI AGarticleAMHPCOShyperandrogenismBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12507, p 12507 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	AMH PCOS hyperandrogenism Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	AMH PCOS hyperandrogenism Biology (General) QH301-705.5 Chemistry QD1-999 Ewa Rudnicka Michał Kunicki Anna Calik-Ksepka Katarzyna Suchta Anna Duszewska Katarzyna Smolarczyk Roman Smolarczyk Anti-Müllerian Hormone in Pathogenesis, Diagnostic and Treatment of PCOS
description	Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among reproductive-aged women. It is characterized by chronic anovulation, hyperandrogenism, and the presence of polycystic ovary in ultrasound examination. PCOS is specified by an increased number of follicles at all growing stages, mainly seen in the preantral and small antral follicles and an increased serum level of Anti-Müllerian Hormone (AMH). Because of the strong correlation between circulating AMH levels and antral follicle count on ultrasound, Anti-Müllerian Hormone has been proposed as an alternative marker of ovulatory dysfunction in PCOS. However, the results from the current literature are not homogeneous, and the specific threshold of AMH in PCOS and PCOM is, therefore, very challenging. This review aims to update the current knowledge about AMH, the pathophysiology of AMH in the pathogenesis of PCOS, and the role of Anti-Müllerian Hormone in the treatment of this syndrome.
format	article
author	Ewa Rudnicka Michał Kunicki Anna Calik-Ksepka Katarzyna Suchta Anna Duszewska Katarzyna Smolarczyk Roman Smolarczyk
author_facet	Ewa Rudnicka Michał Kunicki Anna Calik-Ksepka Katarzyna Suchta Anna Duszewska Katarzyna Smolarczyk Roman Smolarczyk
author_sort	Ewa Rudnicka
title	Anti-Müllerian Hormone in Pathogenesis, Diagnostic and Treatment of PCOS
title_short	Anti-Müllerian Hormone in Pathogenesis, Diagnostic and Treatment of PCOS
title_full	Anti-Müllerian Hormone in Pathogenesis, Diagnostic and Treatment of PCOS
title_fullStr	Anti-Müllerian Hormone in Pathogenesis, Diagnostic and Treatment of PCOS
title_full_unstemmed	Anti-Müllerian Hormone in Pathogenesis, Diagnostic and Treatment of PCOS
title_sort	anti-müllerian hormone in pathogenesis, diagnostic and treatment of pcos
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2e3a546ede3f41e0a171a4b05ae83f69
work_keys_str_mv	AT ewarudnicka antimullerianhormoneinpathogenesisdiagnosticandtreatmentofpcos AT michałkunicki antimullerianhormoneinpathogenesisdiagnosticandtreatmentofpcos AT annacalikksepka antimullerianhormoneinpathogenesisdiagnosticandtreatmentofpcos AT katarzynasuchta antimullerianhormoneinpathogenesisdiagnosticandtreatmentofpcos AT annaduszewska antimullerianhormoneinpathogenesisdiagnosticandtreatmentofpcos AT katarzynasmolarczyk antimullerianhormoneinpathogenesisdiagnosticandtreatmentofpcos AT romansmolarczyk antimullerianhormoneinpathogenesisdiagnosticandtreatmentofpcos
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Anti-Müllerian Hormone in Pathogenesis, Diagnostic and Treatment of PCOS

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