There exists only one tumor necrosis factor

Tumor necrosis factor (TNF) is an important proinflammatory and immunoregulatory cytokine with several unique protective and homeostatic functions. Since TNF is a mediator of several pathologies and is a part of “cytokine storm”, its significance for clinical immunology is due to the fact that this...

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Autor principal:	S. A. Nedospasov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2021
Materias:	tumor necrosis factor lymphotoxin cytokines redundancy Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/2e3a5c7da13c4448bf77f5be2373962c
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spelling	oai:doaj.org-article:2e3a5c7da13c4448bf77f5be2373962c2021-11-18T08:03:50ZThere exists only one tumor necrosis factor1563-06252313-741X10.15789/1563-0625-TEO-000https://doaj.org/article/2e3a5c7da13c4448bf77f5be2373962c2021-01-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/2179https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XTumor necrosis factor (TNF) is an important proinflammatory and immunoregulatory cytokine with several unique protective and homeostatic functions. Since TNF is a mediator of several pathologies and is a part of “cytokine storm”, its significance for clinical immunology is due to the fact that this cytokine is a target of commonly used anti-cytokine therapy in autoimmune and inflammatory diseases. In scientific literature and textbooks TNF is often goes as “TNFa”, implying the existence of at least TNFβ (indeed, such term was used for about 10 years in 80s and 90s to designate lymphotoxin). However, already 25 years ago such designation of lymphotoxin was cancelled “on scientific grounds”. Therefore, both in Russian and in English the term TNF should be used without “alpha”. Labels of the reagents related to TNFb that are offered by commercial companies are misleading.S. A. NedospasovSPb RAACIarticletumor necrosis factorlymphotoxincytokinesredundancyImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 22, Iss 6, Pp 1221-1224 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	tumor necrosis factor lymphotoxin cytokines redundancy Immunologic diseases. Allergy RC581-607
spellingShingle	tumor necrosis factor lymphotoxin cytokines redundancy Immunologic diseases. Allergy RC581-607 S. A. Nedospasov There exists only one tumor necrosis factor
description	Tumor necrosis factor (TNF) is an important proinflammatory and immunoregulatory cytokine with several unique protective and homeostatic functions. Since TNF is a mediator of several pathologies and is a part of “cytokine storm”, its significance for clinical immunology is due to the fact that this cytokine is a target of commonly used anti-cytokine therapy in autoimmune and inflammatory diseases. In scientific literature and textbooks TNF is often goes as “TNFa”, implying the existence of at least TNFβ (indeed, such term was used for about 10 years in 80s and 90s to designate lymphotoxin). However, already 25 years ago such designation of lymphotoxin was cancelled “on scientific grounds”. Therefore, both in Russian and in English the term TNF should be used without “alpha”. Labels of the reagents related to TNFb that are offered by commercial companies are misleading.
format	article
author	S. A. Nedospasov
author_facet	S. A. Nedospasov
author_sort	S. A. Nedospasov
title	There exists only one tumor necrosis factor
title_short	There exists only one tumor necrosis factor
title_full	There exists only one tumor necrosis factor
title_fullStr	There exists only one tumor necrosis factor
title_full_unstemmed	There exists only one tumor necrosis factor
title_sort	there exists only one tumor necrosis factor
publisher	SPb RAACI
publishDate	2021
url	https://doaj.org/article/2e3a5c7da13c4448bf77f5be2373962c
work_keys_str_mv	AT sanedospasov thereexistsonlyonetumornecrosisfactor
_version_	1718422276933681152

There exists only one tumor necrosis factor

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