Cyperus esculentus suppresses hepato-renal oxidative stress, inflammation, and caspase-3 activation following chronic exposure to sodium fluoride in rats’ model

Background: Death arising from hepato-renal related diseases is on the increase. Cyperus esculentus (CE) possesses antioxidants potentials. This study aim at investigating the effect of Cyperus esculentus on sodium fluoride (NaF)-induced hepato-renal toxicity in rats. Methods: Twenty-four male rats...

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Autores principales:	Sunday Aderemi Adelakun, Babatunde Ogunlade, Obinna Peter Fidelis, Oluwafemi Abidemi Adedotun
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Cyperus esculentus Sodium fluoride Kidney Liver Caspase-3 Histology Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/2e3bc6f4ff7c483a8a67ba93a5b69cd7
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spelling	oai:doaj.org-article:2e3bc6f4ff7c483a8a67ba93a5b69cd72021-11-24T04:35:27ZCyperus esculentus suppresses hepato-renal oxidative stress, inflammation, and caspase-3 activation following chronic exposure to sodium fluoride in rats’ model2667-031310.1016/j.phyplu.2021.100163https://doaj.org/article/2e3bc6f4ff7c483a8a67ba93a5b69cd72022-02-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2667031321001457https://doaj.org/toc/2667-0313Background: Death arising from hepato-renal related diseases is on the increase. Cyperus esculentus (CE) possesses antioxidants potentials. This study aim at investigating the effect of Cyperus esculentus on sodium fluoride (NaF)-induced hepato-renal toxicity in rats. Methods: Twenty-four male rats weighting (10–12 weeks old, 200± 20 g) randomized into group A (control) received 1 ml normal saline; group B administered 5 mg/kg bwt of NaF; group C received 500 mg/kg bwt CE; group D received 5 mg/kg bwt NaF and 500 mg/kg bwt CE through gastric gavage for 30 days. Liver and kidney histology, serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH), Creatinine (Cr), and Blood urea nitrogen (BUN), Hepatic and renal nitric oxide (NO), myeloperoxidase (MPO), tumor necrosis factor-alpha (TNF-α), interleukin-1 β (IL-1β), caspase-3, superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPx) and malondialdehyde (MDA) were performed. Results: The observed increases in AST, ALT, ALP, LHD, Cr, and BUN were alleviated in NaF+CE treated rats. The reduction of antioxidant activity was assuaged in rats treated with NaF+CE. In addition, NaF increases liver and kidney MDA, NO, MPO TNF-α, IL-1β, and caspase-3 activity, significantly decreases in rats treated with NaF+CE. Histological observation showed swelling glomeruli and renal tubules lesion while the liver sections showed an extensive histopathological change in NaF exposed rats. However, the intervention of CE alleviated the severity of histopathological lesions induced by NaF. Conclusion: Therefore, CE ameliorate NaF-induced oxidative stress, inflammation, and caspase 3 activation in the liver and kidney of the rats.Sunday Aderemi AdelakunBabatunde OgunladeObinna Peter FidelisOluwafemi Abidemi AdedotunElsevierarticleCyperus esculentusSodium fluorideKidneyLiverCaspase-3HistologyOther systems of medicineRZ201-999ENPhytomedicine Plus, Vol 2, Iss 1, Pp 100163- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cyperus esculentus Sodium fluoride Kidney Liver Caspase-3 Histology Other systems of medicine RZ201-999
spellingShingle	Cyperus esculentus Sodium fluoride Kidney Liver Caspase-3 Histology Other systems of medicine RZ201-999 Sunday Aderemi Adelakun Babatunde Ogunlade Obinna Peter Fidelis Oluwafemi Abidemi Adedotun Cyperus esculentus suppresses hepato-renal oxidative stress, inflammation, and caspase-3 activation following chronic exposure to sodium fluoride in rats’ model
description	Background: Death arising from hepato-renal related diseases is on the increase. Cyperus esculentus (CE) possesses antioxidants potentials. This study aim at investigating the effect of Cyperus esculentus on sodium fluoride (NaF)-induced hepato-renal toxicity in rats. Methods: Twenty-four male rats weighting (10–12 weeks old, 200± 20 g) randomized into group A (control) received 1 ml normal saline; group B administered 5 mg/kg bwt of NaF; group C received 500 mg/kg bwt CE; group D received 5 mg/kg bwt NaF and 500 mg/kg bwt CE through gastric gavage for 30 days. Liver and kidney histology, serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH), Creatinine (Cr), and Blood urea nitrogen (BUN), Hepatic and renal nitric oxide (NO), myeloperoxidase (MPO), tumor necrosis factor-alpha (TNF-α), interleukin-1 β (IL-1β), caspase-3, superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPx) and malondialdehyde (MDA) were performed. Results: The observed increases in AST, ALT, ALP, LHD, Cr, and BUN were alleviated in NaF+CE treated rats. The reduction of antioxidant activity was assuaged in rats treated with NaF+CE. In addition, NaF increases liver and kidney MDA, NO, MPO TNF-α, IL-1β, and caspase-3 activity, significantly decreases in rats treated with NaF+CE. Histological observation showed swelling glomeruli and renal tubules lesion while the liver sections showed an extensive histopathological change in NaF exposed rats. However, the intervention of CE alleviated the severity of histopathological lesions induced by NaF. Conclusion: Therefore, CE ameliorate NaF-induced oxidative stress, inflammation, and caspase 3 activation in the liver and kidney of the rats.
format	article
author	Sunday Aderemi Adelakun Babatunde Ogunlade Obinna Peter Fidelis Oluwafemi Abidemi Adedotun
author_facet	Sunday Aderemi Adelakun Babatunde Ogunlade Obinna Peter Fidelis Oluwafemi Abidemi Adedotun
author_sort	Sunday Aderemi Adelakun
title	Cyperus esculentus suppresses hepato-renal oxidative stress, inflammation, and caspase-3 activation following chronic exposure to sodium fluoride in rats’ model
title_short	Cyperus esculentus suppresses hepato-renal oxidative stress, inflammation, and caspase-3 activation following chronic exposure to sodium fluoride in rats’ model
title_full	Cyperus esculentus suppresses hepato-renal oxidative stress, inflammation, and caspase-3 activation following chronic exposure to sodium fluoride in rats’ model
title_fullStr	Cyperus esculentus suppresses hepato-renal oxidative stress, inflammation, and caspase-3 activation following chronic exposure to sodium fluoride in rats’ model
title_full_unstemmed	Cyperus esculentus suppresses hepato-renal oxidative stress, inflammation, and caspase-3 activation following chronic exposure to sodium fluoride in rats’ model
title_sort	cyperus esculentus suppresses hepato-renal oxidative stress, inflammation, and caspase-3 activation following chronic exposure to sodium fluoride in rats’ model
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/2e3bc6f4ff7c483a8a67ba93a5b69cd7
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Cyperus esculentus suppresses hepato-renal oxidative stress, inflammation, and caspase-3 activation following chronic exposure to sodium fluoride in rats’ model

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