Presentation and outcomes of chronic rhinosinusitis following liver and kidney transplant

Objective: This study aims to describe presenting characteristics of patients diagnosed with non-invasive chronic rhinosinusitis (CRS) following liver or kidney transplant and determine factors associated with disease-related complications, selection of endoscopic sinus surgery (ESS), and disease re...

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Autores principales:	Aviv Spillinger, Christopher M. Low, Byron M. Smith, Janalee K. Stokken, Erin K. O'Brien, Garret Choby
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2021
Materias:	Rhinosinusitis Chronic rhinosinusitis Non-invasive rhinosinusitis Kidney transplant Liver transplant Immunocompromised Otorhinolaryngology RF1-547 Surgery RD1-811
Acceso en línea:	https://doaj.org/article/2e3d363c15bd400eaf530d36918e2fb1
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spelling	oai:doaj.org-article:2e3d363c15bd400eaf530d36918e2fb12021-12-02T16:44:57ZPresentation and outcomes of chronic rhinosinusitis following liver and kidney transplant2095-881110.1016/j.wjorl.2020.05.001https://doaj.org/article/2e3d363c15bd400eaf530d36918e2fb12021-04-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S209588112030055Xhttps://doaj.org/toc/2095-8811Objective: This study aims to describe presenting characteristics of patients diagnosed with non-invasive chronic rhinosinusitis (CRS) following liver or kidney transplant and determine factors associated with disease-related complications, selection of endoscopic sinus surgery (ESS), and disease resolution in this population. Study design: Retrospective chart review. Setting: An academic tertiary care center (Mayo Clinic, Rochester, Minnesota). Subjects and methods: Liver and kidney transplant recipients evaluated by Mayo Clinic otolaryngologists for CRS between 1998 and 2018 were identified. Univariate and multivariate logistic regression analyses were used to determine patient factors and treatment modalities associated with developing complications, selection of ESS, and disease resolution. Results: Fifty-seven patients met inclusion criteria. No patients developed intraorbital or intracranial complications of their CRS. Multivariate modeling demonstrated that the presence of polyps (P = 0.036) was associated with undergoing ESS within one year of presentation. A higher Lund–Mackay (LM) computed tomography score (P = 0.023) and older age (P = 0.018) were significantly associated with decreased disease resolution. No other factors were significantly associated with the use of endoscopic sinus surgery within one year of otolaryngology presentation or resolution of CRS in this cohort. Conclusion: The risk of developing CRS-related intraorbital or intracranial complications in this immunecompromised patient cohort may be lower than originally thought. For liver- and kidney-recipients stable on immunosuppressive medication for many years, prognostic factors for CRS may mirror those for immunocompetent patients.Aviv SpillingerChristopher M. LowByron M. SmithJanalee K. StokkenErin K. O'BrienGarret ChobyKeAi Communications Co., Ltd.articleRhinosinusitisChronic rhinosinusitisNon-invasive rhinosinusitisKidney transplantLiver transplantImmunocompromisedOtorhinolaryngologyRF1-547SurgeryRD1-811ENWorld Journal of Otorhinolaryngology-Head and Neck Surgery, Vol 7, Iss 2, Pp 139-145 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Rhinosinusitis Chronic rhinosinusitis Non-invasive rhinosinusitis Kidney transplant Liver transplant Immunocompromised Otorhinolaryngology RF1-547 Surgery RD1-811
spellingShingle	Rhinosinusitis Chronic rhinosinusitis Non-invasive rhinosinusitis Kidney transplant Liver transplant Immunocompromised Otorhinolaryngology RF1-547 Surgery RD1-811 Aviv Spillinger Christopher M. Low Byron M. Smith Janalee K. Stokken Erin K. O'Brien Garret Choby Presentation and outcomes of chronic rhinosinusitis following liver and kidney transplant
description	Objective: This study aims to describe presenting characteristics of patients diagnosed with non-invasive chronic rhinosinusitis (CRS) following liver or kidney transplant and determine factors associated with disease-related complications, selection of endoscopic sinus surgery (ESS), and disease resolution in this population. Study design: Retrospective chart review. Setting: An academic tertiary care center (Mayo Clinic, Rochester, Minnesota). Subjects and methods: Liver and kidney transplant recipients evaluated by Mayo Clinic otolaryngologists for CRS between 1998 and 2018 were identified. Univariate and multivariate logistic regression analyses were used to determine patient factors and treatment modalities associated with developing complications, selection of ESS, and disease resolution. Results: Fifty-seven patients met inclusion criteria. No patients developed intraorbital or intracranial complications of their CRS. Multivariate modeling demonstrated that the presence of polyps (P = 0.036) was associated with undergoing ESS within one year of presentation. A higher Lund–Mackay (LM) computed tomography score (P = 0.023) and older age (P = 0.018) were significantly associated with decreased disease resolution. No other factors were significantly associated with the use of endoscopic sinus surgery within one year of otolaryngology presentation or resolution of CRS in this cohort. Conclusion: The risk of developing CRS-related intraorbital or intracranial complications in this immunecompromised patient cohort may be lower than originally thought. For liver- and kidney-recipients stable on immunosuppressive medication for many years, prognostic factors for CRS may mirror those for immunocompetent patients.
format	article
author	Aviv Spillinger Christopher M. Low Byron M. Smith Janalee K. Stokken Erin K. O'Brien Garret Choby
author_facet	Aviv Spillinger Christopher M. Low Byron M. Smith Janalee K. Stokken Erin K. O'Brien Garret Choby
author_sort	Aviv Spillinger
title	Presentation and outcomes of chronic rhinosinusitis following liver and kidney transplant
title_short	Presentation and outcomes of chronic rhinosinusitis following liver and kidney transplant
title_full	Presentation and outcomes of chronic rhinosinusitis following liver and kidney transplant
title_fullStr	Presentation and outcomes of chronic rhinosinusitis following liver and kidney transplant
title_full_unstemmed	Presentation and outcomes of chronic rhinosinusitis following liver and kidney transplant
title_sort	presentation and outcomes of chronic rhinosinusitis following liver and kidney transplant
publisher	KeAi Communications Co., Ltd.
publishDate	2021
url	https://doaj.org/article/2e3d363c15bd400eaf530d36918e2fb1
work_keys_str_mv	AT avivspillinger presentationandoutcomesofchronicrhinosinusitisfollowingliverandkidneytransplant AT christophermlow presentationandoutcomesofchronicrhinosinusitisfollowingliverandkidneytransplant AT byronmsmith presentationandoutcomesofchronicrhinosinusitisfollowingliverandkidneytransplant AT janaleekstokken presentationandoutcomesofchronicrhinosinusitisfollowingliverandkidneytransplant AT erinkobrien presentationandoutcomesofchronicrhinosinusitisfollowingliverandkidneytransplant AT garretchoby presentationandoutcomesofchronicrhinosinusitisfollowingliverandkidneytransplant
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Presentation and outcomes of chronic rhinosinusitis following liver and kidney transplant

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