Relationship between indirect genetic effects for growth, environmental enrichment, coping style and sex with the serum metabolome profile of pigs

Abstract Including Indirect Genetic Effects (IGE) in breeding programs to reduce aggression in group housed animals has been proposed. However, the effect of selection for IGE for growth on animal metabolism and physiology is unknown. The purpose of this study was twofold: (1) To investigate the eff...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Elda Dervishi, Inonge Reimert, Lisette E. van der Zande, Pramod Mathur, Egbert F. Knol, Graham S. Plastow
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2e41a830891b42a181fb0e1300c56bc8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2e41a830891b42a181fb0e1300c56bc8
record_format	dspace
spelling	oai:doaj.org-article:2e41a830891b42a181fb0e1300c56bc82021-12-05T12:12:30ZRelationship between indirect genetic effects for growth, environmental enrichment, coping style and sex with the serum metabolome profile of pigs10.1038/s41598-021-02814-x2045-2322https://doaj.org/article/2e41a830891b42a181fb0e1300c56bc82021-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02814-xhttps://doaj.org/toc/2045-2322Abstract Including Indirect Genetic Effects (IGE) in breeding programs to reduce aggression in group housed animals has been proposed. However, the effect of selection for IGE for growth on animal metabolism and physiology is unknown. The purpose of this study was twofold: (1) To investigate the effects of this new breeding method along with two housing (barren and straw), coping style (high and low resisters) and sex (female and castrated males) options on the metabolome profile of pigs. (2) To identify and map biological processes associated with a regrouping test at 9 weeks of age. We used Nuclear Magnetic Resonance to quantify 49 serum metabolites at week 8, 9 and 22. Also, we quantified 3 catecholamines (tyramine, epinephrine, phenylethylamine) and serotonin and three water soluble vitamins (B2, B5 and B7). Overall, no significant differences were observed between negative and positive IGE animals. The magnitude of change (delta) of many metabolites as a response to the regrouping test was significantly affected by IGE, especially that of the amino acids (P < 0.05), being greater in positive IGE pigs. The regrouping test was associated with alteration in glycine, serine and threonine metabolism. In conclusion positive and negative IGE animals respond differently to the regrouping test.Elda DervishiInonge ReimertLisette E. van der ZandePramod MathurEgbert F. KnolGraham S. PlastowNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elda Dervishi Inonge Reimert Lisette E. van der Zande Pramod Mathur Egbert F. Knol Graham S. Plastow Relationship between indirect genetic effects for growth, environmental enrichment, coping style and sex with the serum metabolome profile of pigs
description	Abstract Including Indirect Genetic Effects (IGE) in breeding programs to reduce aggression in group housed animals has been proposed. However, the effect of selection for IGE for growth on animal metabolism and physiology is unknown. The purpose of this study was twofold: (1) To investigate the effects of this new breeding method along with two housing (barren and straw), coping style (high and low resisters) and sex (female and castrated males) options on the metabolome profile of pigs. (2) To identify and map biological processes associated with a regrouping test at 9 weeks of age. We used Nuclear Magnetic Resonance to quantify 49 serum metabolites at week 8, 9 and 22. Also, we quantified 3 catecholamines (tyramine, epinephrine, phenylethylamine) and serotonin and three water soluble vitamins (B2, B5 and B7). Overall, no significant differences were observed between negative and positive IGE animals. The magnitude of change (delta) of many metabolites as a response to the regrouping test was significantly affected by IGE, especially that of the amino acids (P < 0.05), being greater in positive IGE pigs. The regrouping test was associated with alteration in glycine, serine and threonine metabolism. In conclusion positive and negative IGE animals respond differently to the regrouping test.
format	article
author	Elda Dervishi Inonge Reimert Lisette E. van der Zande Pramod Mathur Egbert F. Knol Graham S. Plastow
author_facet	Elda Dervishi Inonge Reimert Lisette E. van der Zande Pramod Mathur Egbert F. Knol Graham S. Plastow
author_sort	Elda Dervishi
title	Relationship between indirect genetic effects for growth, environmental enrichment, coping style and sex with the serum metabolome profile of pigs
title_short	Relationship between indirect genetic effects for growth, environmental enrichment, coping style and sex with the serum metabolome profile of pigs
title_full	Relationship between indirect genetic effects for growth, environmental enrichment, coping style and sex with the serum metabolome profile of pigs
title_fullStr	Relationship between indirect genetic effects for growth, environmental enrichment, coping style and sex with the serum metabolome profile of pigs
title_full_unstemmed	Relationship between indirect genetic effects for growth, environmental enrichment, coping style and sex with the serum metabolome profile of pigs
title_sort	relationship between indirect genetic effects for growth, environmental enrichment, coping style and sex with the serum metabolome profile of pigs
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2e41a830891b42a181fb0e1300c56bc8
work_keys_str_mv	AT eldadervishi relationshipbetweenindirectgeneticeffectsforgrowthenvironmentalenrichmentcopingstyleandsexwiththeserummetabolomeprofileofpigs AT inongereimert relationshipbetweenindirectgeneticeffectsforgrowthenvironmentalenrichmentcopingstyleandsexwiththeserummetabolomeprofileofpigs AT lisetteevanderzande relationshipbetweenindirectgeneticeffectsforgrowthenvironmentalenrichmentcopingstyleandsexwiththeserummetabolomeprofileofpigs AT pramodmathur relationshipbetweenindirectgeneticeffectsforgrowthenvironmentalenrichmentcopingstyleandsexwiththeserummetabolomeprofileofpigs AT egbertfknol relationshipbetweenindirectgeneticeffectsforgrowthenvironmentalenrichmentcopingstyleandsexwiththeserummetabolomeprofileofpigs AT grahamsplastow relationshipbetweenindirectgeneticeffectsforgrowthenvironmentalenrichmentcopingstyleandsexwiththeserummetabolomeprofileofpigs
_version_	1718372123713470464

Relationship between indirect genetic effects for growth, environmental enrichment, coping style and sex with the serum metabolome profile of pigs

Ejemplares similares