PD-1 suppresses TCR-CD8 cooperativity during T-cell antigen recognition

The mechanistic detail of how PD-1 inhibits T cell activation is lacking. Here, the authors show PD-1 suppresses the cooperative TCR–pMHC–CD8 interaction by inhibiting TCR proximal signalling.

Guardado en:

Detalles Bibliográficos
Autores principales:	Kaitao Li, Zhou Yuan, Jintian Lyu, Eunseon Ahn, Simon J. Davis, Rafi Ahmed, Cheng Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2e4502623e2b43e3b586f623ee548395
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2e4502623e2b43e3b586f623ee548395
record_format	dspace
spelling	oai:doaj.org-article:2e4502623e2b43e3b586f623ee5483952021-12-02T16:50:35ZPD-1 suppresses TCR-CD8 cooperativity during T-cell antigen recognition10.1038/s41467-021-22965-92041-1723https://doaj.org/article/2e4502623e2b43e3b586f623ee5483952021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22965-9https://doaj.org/toc/2041-1723The mechanistic detail of how PD-1 inhibits T cell activation is lacking. Here, the authors show PD-1 suppresses the cooperative TCR–pMHC–CD8 interaction by inhibiting TCR proximal signalling.Kaitao LiZhou YuanJintian LyuEunseon AhnSimon J. DavisRafi AhmedCheng ZhuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kaitao Li Zhou Yuan Jintian Lyu Eunseon Ahn Simon J. Davis Rafi Ahmed Cheng Zhu PD-1 suppresses TCR-CD8 cooperativity during T-cell antigen recognition
description	The mechanistic detail of how PD-1 inhibits T cell activation is lacking. Here, the authors show PD-1 suppresses the cooperative TCR–pMHC–CD8 interaction by inhibiting TCR proximal signalling.
format	article
author	Kaitao Li Zhou Yuan Jintian Lyu Eunseon Ahn Simon J. Davis Rafi Ahmed Cheng Zhu
author_facet	Kaitao Li Zhou Yuan Jintian Lyu Eunseon Ahn Simon J. Davis Rafi Ahmed Cheng Zhu
author_sort	Kaitao Li
title	PD-1 suppresses TCR-CD8 cooperativity during T-cell antigen recognition
title_short	PD-1 suppresses TCR-CD8 cooperativity during T-cell antigen recognition
title_full	PD-1 suppresses TCR-CD8 cooperativity during T-cell antigen recognition
title_fullStr	PD-1 suppresses TCR-CD8 cooperativity during T-cell antigen recognition
title_full_unstemmed	PD-1 suppresses TCR-CD8 cooperativity during T-cell antigen recognition
title_sort	pd-1 suppresses tcr-cd8 cooperativity during t-cell antigen recognition
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2e4502623e2b43e3b586f623ee548395
work_keys_str_mv	AT kaitaoli pd1suppressestcrcd8cooperativityduringtcellantigenrecognition AT zhouyuan pd1suppressestcrcd8cooperativityduringtcellantigenrecognition AT jintianlyu pd1suppressestcrcd8cooperativityduringtcellantigenrecognition AT eunseonahn pd1suppressestcrcd8cooperativityduringtcellantigenrecognition AT simonjdavis pd1suppressestcrcd8cooperativityduringtcellantigenrecognition AT rafiahmed pd1suppressestcrcd8cooperativityduringtcellantigenrecognition AT chengzhu pd1suppressestcrcd8cooperativityduringtcellantigenrecognition
_version_	1718383027809157120

PD-1 suppresses TCR-CD8 cooperativity during T-cell antigen recognition

Ejemplares similares