Clinical and immunological allergy assessment in cancer patients

Abstract Cancer is associated with immunodeficiency, while allergies result from immune system hyperactivity mediated by cytokines and immunoglobulins. The purpose of this study was to determine the relationship between immune environment of specific cancers and allergies, emphasizing cytokines rela...

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Autores principales:	Bruno Gustavo Muzzi Carvalho Carneiro, Andy Petroianu, José Augusto Nogueira Machado, Paula Martins Ferreira dos Anjos, Fabiana Rocha da Silva, Luiz Ronaldo Alberti, Vivian Resende, Sofia Candia Barrientos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2e458126e5d04ac98a04386403ad7f3e
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spelling	oai:doaj.org-article:2e458126e5d04ac98a04386403ad7f3e2021-12-02T18:33:51ZClinical and immunological allergy assessment in cancer patients10.1038/s41598-021-97200-y2045-2322https://doaj.org/article/2e458126e5d04ac98a04386403ad7f3e2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97200-yhttps://doaj.org/toc/2045-2322Abstract Cancer is associated with immunodeficiency, while allergies result from immune system hyperactivity mediated by cytokines and immunoglobulins. The purpose of this study was to determine the relationship between immune environment of specific cancers and allergies, emphasizing cytokines related to Th1 and Th2 responses associated with IgE. 80 adults were distributed into two groups: control (n = 20) and cancer (n = 60), distributed in three subgroups (n = 20), head and neck, stomach, and prostate cancers. This study compared Th1 (IL-2) and Th2 (IL-4) parameters, anti-inflammatory, pro-inflammatory, or regulatory profile regarding both IgE levels and reported allergies, by means of clinical manifestations and IgE, IL-1β, IL-2, IL-4, IL-17, and TGF-β serum concentration. Clinically allergies were observed in 50% of the control group and in 20% of the cancer group (p = 0.009). IL-2 cytokine and TGF-β concentrations were higher in the patients with cancer as compared to the control (p < 0.005). However, there were IL-4, IL-17, and IL-1β decreases in the patients with cancer (p < 0.05). No correlation was observed between the cytokines studied and IgE and clinically proven allergies in both investigated groups. There was an inverse association between cancer and clinical allergy manifestations. In head and neck, stomach, and prostate cancers, an immunosuppressive serum tumor environment was predominant. There was no difference in cytokines related to Th1 and Th2 parameters in relation to IgE. No correlation was found between clinically proved allergies and immunity markers related to the same allergens.Bruno Gustavo Muzzi Carvalho CarneiroAndy PetroianuJosé Augusto Nogueira MachadoPaula Martins Ferreira dos AnjosFabiana Rocha da SilvaLuiz Ronaldo AlbertiVivian ResendeSofia Candia BarrientosNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bruno Gustavo Muzzi Carvalho Carneiro Andy Petroianu José Augusto Nogueira Machado Paula Martins Ferreira dos Anjos Fabiana Rocha da Silva Luiz Ronaldo Alberti Vivian Resende Sofia Candia Barrientos Clinical and immunological allergy assessment in cancer patients
description	Abstract Cancer is associated with immunodeficiency, while allergies result from immune system hyperactivity mediated by cytokines and immunoglobulins. The purpose of this study was to determine the relationship between immune environment of specific cancers and allergies, emphasizing cytokines related to Th1 and Th2 responses associated with IgE. 80 adults were distributed into two groups: control (n = 20) and cancer (n = 60), distributed in three subgroups (n = 20), head and neck, stomach, and prostate cancers. This study compared Th1 (IL-2) and Th2 (IL-4) parameters, anti-inflammatory, pro-inflammatory, or regulatory profile regarding both IgE levels and reported allergies, by means of clinical manifestations and IgE, IL-1β, IL-2, IL-4, IL-17, and TGF-β serum concentration. Clinically allergies were observed in 50% of the control group and in 20% of the cancer group (p = 0.009). IL-2 cytokine and TGF-β concentrations were higher in the patients with cancer as compared to the control (p < 0.005). However, there were IL-4, IL-17, and IL-1β decreases in the patients with cancer (p < 0.05). No correlation was observed between the cytokines studied and IgE and clinically proven allergies in both investigated groups. There was an inverse association between cancer and clinical allergy manifestations. In head and neck, stomach, and prostate cancers, an immunosuppressive serum tumor environment was predominant. There was no difference in cytokines related to Th1 and Th2 parameters in relation to IgE. No correlation was found between clinically proved allergies and immunity markers related to the same allergens.
format	article
author	Bruno Gustavo Muzzi Carvalho Carneiro Andy Petroianu José Augusto Nogueira Machado Paula Martins Ferreira dos Anjos Fabiana Rocha da Silva Luiz Ronaldo Alberti Vivian Resende Sofia Candia Barrientos
author_facet	Bruno Gustavo Muzzi Carvalho Carneiro Andy Petroianu José Augusto Nogueira Machado Paula Martins Ferreira dos Anjos Fabiana Rocha da Silva Luiz Ronaldo Alberti Vivian Resende Sofia Candia Barrientos
author_sort	Bruno Gustavo Muzzi Carvalho Carneiro
title	Clinical and immunological allergy assessment in cancer patients
title_short	Clinical and immunological allergy assessment in cancer patients
title_full	Clinical and immunological allergy assessment in cancer patients
title_fullStr	Clinical and immunological allergy assessment in cancer patients
title_full_unstemmed	Clinical and immunological allergy assessment in cancer patients
title_sort	clinical and immunological allergy assessment in cancer patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2e458126e5d04ac98a04386403ad7f3e
work_keys_str_mv	AT brunogustavomuzzicarvalhocarneiro clinicalandimmunologicalallergyassessmentincancerpatients AT andypetroianu clinicalandimmunologicalallergyassessmentincancerpatients AT joseaugustonogueiramachado clinicalandimmunologicalallergyassessmentincancerpatients AT paulamartinsferreiradosanjos clinicalandimmunologicalallergyassessmentincancerpatients AT fabianarochadasilva clinicalandimmunologicalallergyassessmentincancerpatients AT luizronaldoalberti clinicalandimmunologicalallergyassessmentincancerpatients AT vivianresende clinicalandimmunologicalallergyassessmentincancerpatients AT sofiacandiabarrientos clinicalandimmunologicalallergyassessmentincancerpatients
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Clinical and immunological allergy assessment in cancer patients

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