RESPONSE OF MONONUCLEAR CELLS TO CANCER-ASSOCIATED ANTIGENS, HUMORAL FACTORS OF IMMUNITY, AND PATHOHISTOLOGICAL FINDINGS IN WOMEN WITH GENITAL MALIGNANCIES CERVICAL EPITHELIAL DYSPLASIA

Abstract. In vitro response of blood mononuclear cells to cancer-associated antigens was studied in women with genital pathology, and these results were compared with serum levels of pro- and anti-inflammatory factors of immunity, like as with histological features of genital cancer and cervical epi...

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Autores principales:	A. I. Autenshlus, A. P. Lykov, A. N. Shcunov, N. A. Varaksin, D. V. Morozov, V. B. Prohozhev, E. S. Mikhayllova, G. А. Кretinin, S. E. Krasillnikov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	mononuclear cells antigens cytokines antibodies cancer epithelial dysplasia Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/2e45de629f514fad99b14928cc03df21
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spelling	oai:doaj.org-article:2e45de629f514fad99b14928cc03df212021-11-18T08:03:39ZRESPONSE OF MONONUCLEAR CELLS TO CANCER-ASSOCIATED ANTIGENS, HUMORAL FACTORS OF IMMUNITY, AND PATHOHISTOLOGICAL FINDINGS IN WOMEN WITH GENITAL MALIGNANCIES CERVICAL EPITHELIAL DYSPLASIA1563-06252313-741X10.15789/1563-0625-2007-4-5-513-518https://doaj.org/article/2e45de629f514fad99b14928cc03df212014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/232https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. In vitro response of blood mononuclear cells to cancer-associated antigens was studied in women with genital pathology, and these results were compared with serum levels of pro- and anti-inflammatory factors of immunity, like as with histological features of genital cancer and cervical epithelial dysplasia. In vitro cellular response was regarded as positive, if relative amounts of CD8-positive lymphocytes increased by > 15% following incubation of blood mononuclears with cancer-associated antigens. Positive reaction and elevated serum levels of anti-TNFα and anti-IFNγ antibodies were associated with lesser malignancy of tumor, as proven by histological findings in the women with genital cancer. A positive cellular reaction was associated with increased serum levels of IFNγ and anti-TNFα in women with grade II–III cervical epithelial dysplasia. It is concluded about potential applicability of testing mononuclears with fetal proteins, to determine a grade of malignancy for the female genital tumors, as well as a degree of regenerative disturbances of cervical epithelium.A. I. AutenshlusA. P. LykovA. N. ShcunovN. A. VaraksinD. V. MorozovV. B. ProhozhevE. S. MikhayllovaG. А. КretininS. E. KrasillnikovSPb RAACIarticlemononuclear cellsantigenscytokinesantibodiescancerepithelial dysplasiaImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 9, Iss 4-5, Pp 513-518 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	mononuclear cells antigens cytokines antibodies cancer epithelial dysplasia Immunologic diseases. Allergy RC581-607
spellingShingle	mononuclear cells antigens cytokines antibodies cancer epithelial dysplasia Immunologic diseases. Allergy RC581-607 A. I. Autenshlus A. P. Lykov A. N. Shcunov N. A. Varaksin D. V. Morozov V. B. Prohozhev E. S. Mikhayllova G. А. Кretinin S. E. Krasillnikov RESPONSE OF MONONUCLEAR CELLS TO CANCER-ASSOCIATED ANTIGENS, HUMORAL FACTORS OF IMMUNITY, AND PATHOHISTOLOGICAL FINDINGS IN WOMEN WITH GENITAL MALIGNANCIES CERVICAL EPITHELIAL DYSPLASIA
description	Abstract. In vitro response of blood mononuclear cells to cancer-associated antigens was studied in women with genital pathology, and these results were compared with serum levels of pro- and anti-inflammatory factors of immunity, like as with histological features of genital cancer and cervical epithelial dysplasia. In vitro cellular response was regarded as positive, if relative amounts of CD8-positive lymphocytes increased by > 15% following incubation of blood mononuclears with cancer-associated antigens. Positive reaction and elevated serum levels of anti-TNFα and anti-IFNγ antibodies were associated with lesser malignancy of tumor, as proven by histological findings in the women with genital cancer. A positive cellular reaction was associated with increased serum levels of IFNγ and anti-TNFα in women with grade II–III cervical epithelial dysplasia. It is concluded about potential applicability of testing mononuclears with fetal proteins, to determine a grade of malignancy for the female genital tumors, as well as a degree of regenerative disturbances of cervical epithelium.
format	article
author	A. I. Autenshlus A. P. Lykov A. N. Shcunov N. A. Varaksin D. V. Morozov V. B. Prohozhev E. S. Mikhayllova G. А. Кretinin S. E. Krasillnikov
author_facet	A. I. Autenshlus A. P. Lykov A. N. Shcunov N. A. Varaksin D. V. Morozov V. B. Prohozhev E. S. Mikhayllova G. А. Кretinin S. E. Krasillnikov
author_sort	A. I. Autenshlus
title	RESPONSE OF MONONUCLEAR CELLS TO CANCER-ASSOCIATED ANTIGENS, HUMORAL FACTORS OF IMMUNITY, AND PATHOHISTOLOGICAL FINDINGS IN WOMEN WITH GENITAL MALIGNANCIES CERVICAL EPITHELIAL DYSPLASIA
title_short	RESPONSE OF MONONUCLEAR CELLS TO CANCER-ASSOCIATED ANTIGENS, HUMORAL FACTORS OF IMMUNITY, AND PATHOHISTOLOGICAL FINDINGS IN WOMEN WITH GENITAL MALIGNANCIES CERVICAL EPITHELIAL DYSPLASIA
title_full	RESPONSE OF MONONUCLEAR CELLS TO CANCER-ASSOCIATED ANTIGENS, HUMORAL FACTORS OF IMMUNITY, AND PATHOHISTOLOGICAL FINDINGS IN WOMEN WITH GENITAL MALIGNANCIES CERVICAL EPITHELIAL DYSPLASIA
title_fullStr	RESPONSE OF MONONUCLEAR CELLS TO CANCER-ASSOCIATED ANTIGENS, HUMORAL FACTORS OF IMMUNITY, AND PATHOHISTOLOGICAL FINDINGS IN WOMEN WITH GENITAL MALIGNANCIES CERVICAL EPITHELIAL DYSPLASIA
title_full_unstemmed	RESPONSE OF MONONUCLEAR CELLS TO CANCER-ASSOCIATED ANTIGENS, HUMORAL FACTORS OF IMMUNITY, AND PATHOHISTOLOGICAL FINDINGS IN WOMEN WITH GENITAL MALIGNANCIES CERVICAL EPITHELIAL DYSPLASIA
title_sort	response of mononuclear cells to cancer-associated antigens, humoral factors of immunity, and pathohistological findings in women with genital malignancies cervical epithelial dysplasia
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/2e45de629f514fad99b14928cc03df21
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RESPONSE OF MONONUCLEAR CELLS TO CANCER-ASSOCIATED ANTIGENS, HUMORAL FACTORS OF IMMUNITY, AND PATHOHISTOLOGICAL FINDINGS IN WOMEN WITH GENITAL MALIGNANCIES CERVICAL EPITHELIAL DYSPLASIA

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