Gut Microbiota Changes and Their Relationship with Inflammation in Patients with Acute and Chronic Insomnia
Yuanyuan Li,1,2,* Bin Zhang,3,* Ya Zhou,4 Daoming Wang,5 Xianchen Liu,1,6 Lin Li,1 Tong Wang,1 Yuechu Zhang,1 Min Jiang,1 Huilan Tang,7 Lawrence V Amsel,7 Fang Fan,1 Christina W Hoven7 1Key Laboratory of Brain, Cognition and Education Sciences, Ministry of Education, China; School of Psychology, Cen...
Guardado en:
| Autores principales: | , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2020
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/2e46032d1f3e4c7c87880e4420f8d670 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:2e46032d1f3e4c7c87880e4420f8d670 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:2e46032d1f3e4c7c87880e4420f8d6702021-12-02T12:48:16ZGut Microbiota Changes and Their Relationship with Inflammation in Patients with Acute and Chronic Insomnia1179-1608https://doaj.org/article/2e46032d1f3e4c7c87880e4420f8d6702020-11-01T00:00:00Zhttps://www.dovepress.com/gut-microbiota-changes-and-their-relationship-with-inflammation-in-pat-peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Yuanyuan Li,1,2,* Bin Zhang,3,* Ya Zhou,4 Daoming Wang,5 Xianchen Liu,1,6 Lin Li,1 Tong Wang,1 Yuechu Zhang,1 Min Jiang,1 Huilan Tang,7 Lawrence V Amsel,7 Fang Fan,1 Christina W Hoven7 1Key Laboratory of Brain, Cognition and Education Sciences, Ministry of Education, China; School of Psychology, Center for Studies of Psychological Application, and Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, People’s Republic of China; 2Expressive Arts Therapy Department, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China; 3Department of Psychiatry, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China; 4Department of Psychology, Lund University, Lund, Sweden; 5School of Future Technology, University of Chinese Academy of Sciences, Beijing, People’s Republic of China; 6The University of Tennessee Health Science Center, Memphis, TN, USA; 7Department of Child and Adolescent Psychiatry, New York State Psychiatric Institute, Columbia University, New York, NY, USA*These authors contributed equally to this workCorrespondence: Fang FanSchool of Psychology, Center for Studies of Psychological Application, South China Normal University, Guangzhou 510631, People’s Republic of ChinaEmail fangfan@scnu.edu.cnPurpose: The major purpose of this study was to detect the changes in gut microbiota composition and inflammatory cytokines production associated with acute and chronic insomnia. This study also evaluated the relationship between gut microbiota changes and increased inflammatory cytokines in insomnia patients.Patients and Methods: Outpatients with acute and chronic insomnia (aged 26– 55 years; n=20 and 38, respectively) and age/gender-matched healthy controls (n=38) were recruited from a southern China region. Participants’ gut microbiome, plasma cytokines, and self-reported sleep quality and psychopathological symptoms were measured.Results: The gut microbiomes of insomnia patients compared with healthy controls were characterized by lower microbial richness and diversity, depletion of anaerobes, and short-chain fatty acid (SCFA)-producing bacteria, and an expansion of potential pathobionts. Lachnospira and Bacteroides were signature bacteria for distinguishing acute insomnia patients from healthy controls, while Faecalibacterium and Blautia were signature bacteria for distinguishing chronic insomnia patients from healthy controls. Acute/chronic insomnia-related signature bacteria also showed correlations with these patients’ self-reported sleep quality and plasma IL-1β.Conclusion: These findings suggest that insomnia symptomology, gut microbiota, and inflammation may be interrelated in complex ways. Gut microbiota may serve as an important indicator for auxiliary diagnosis of insomnia and provide possible new therapeutic targets in the field of sleep disorders.Keywords: acute insomnia, chronic insomnia, gut microbiome, inflammatory cytokines, random forestLi YZhang BZhou YWang DLiu XLi LWang TZhang YJiang MTang HAmsel LVFan FHoven CWDove Medical Pressarticleacute insomniachronic insomniagut microbiomeinflammatory cytokinesrandom forestPsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 12, Pp 895-905 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
acute insomnia chronic insomnia gut microbiome inflammatory cytokines random forest Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 |
| spellingShingle |
acute insomnia chronic insomnia gut microbiome inflammatory cytokines random forest Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Li Y Zhang B Zhou Y Wang D Liu X Li L Wang T Zhang Y Jiang M Tang H Amsel LV Fan F Hoven CW Gut Microbiota Changes and Their Relationship with Inflammation in Patients with Acute and Chronic Insomnia |
| description |
Yuanyuan Li,1,2,* Bin Zhang,3,* Ya Zhou,4 Daoming Wang,5 Xianchen Liu,1,6 Lin Li,1 Tong Wang,1 Yuechu Zhang,1 Min Jiang,1 Huilan Tang,7 Lawrence V Amsel,7 Fang Fan,1 Christina W Hoven7 1Key Laboratory of Brain, Cognition and Education Sciences, Ministry of Education, China; School of Psychology, Center for Studies of Psychological Application, and Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, People’s Republic of China; 2Expressive Arts Therapy Department, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China; 3Department of Psychiatry, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China; 4Department of Psychology, Lund University, Lund, Sweden; 5School of Future Technology, University of Chinese Academy of Sciences, Beijing, People’s Republic of China; 6The University of Tennessee Health Science Center, Memphis, TN, USA; 7Department of Child and Adolescent Psychiatry, New York State Psychiatric Institute, Columbia University, New York, NY, USA*These authors contributed equally to this workCorrespondence: Fang FanSchool of Psychology, Center for Studies of Psychological Application, South China Normal University, Guangzhou 510631, People’s Republic of ChinaEmail fangfan@scnu.edu.cnPurpose: The major purpose of this study was to detect the changes in gut microbiota composition and inflammatory cytokines production associated with acute and chronic insomnia. This study also evaluated the relationship between gut microbiota changes and increased inflammatory cytokines in insomnia patients.Patients and Methods: Outpatients with acute and chronic insomnia (aged 26– 55 years; n=20 and 38, respectively) and age/gender-matched healthy controls (n=38) were recruited from a southern China region. Participants’ gut microbiome, plasma cytokines, and self-reported sleep quality and psychopathological symptoms were measured.Results: The gut microbiomes of insomnia patients compared with healthy controls were characterized by lower microbial richness and diversity, depletion of anaerobes, and short-chain fatty acid (SCFA)-producing bacteria, and an expansion of potential pathobionts. Lachnospira and Bacteroides were signature bacteria for distinguishing acute insomnia patients from healthy controls, while Faecalibacterium and Blautia were signature bacteria for distinguishing chronic insomnia patients from healthy controls. Acute/chronic insomnia-related signature bacteria also showed correlations with these patients’ self-reported sleep quality and plasma IL-1β.Conclusion: These findings suggest that insomnia symptomology, gut microbiota, and inflammation may be interrelated in complex ways. Gut microbiota may serve as an important indicator for auxiliary diagnosis of insomnia and provide possible new therapeutic targets in the field of sleep disorders.Keywords: acute insomnia, chronic insomnia, gut microbiome, inflammatory cytokines, random forest |
| format |
article |
| author |
Li Y Zhang B Zhou Y Wang D Liu X Li L Wang T Zhang Y Jiang M Tang H Amsel LV Fan F Hoven CW |
| author_facet |
Li Y Zhang B Zhou Y Wang D Liu X Li L Wang T Zhang Y Jiang M Tang H Amsel LV Fan F Hoven CW |
| author_sort |
Li Y |
| title |
Gut Microbiota Changes and Their Relationship with Inflammation in Patients with Acute and Chronic Insomnia |
| title_short |
Gut Microbiota Changes and Their Relationship with Inflammation in Patients with Acute and Chronic Insomnia |
| title_full |
Gut Microbiota Changes and Their Relationship with Inflammation in Patients with Acute and Chronic Insomnia |
| title_fullStr |
Gut Microbiota Changes and Their Relationship with Inflammation in Patients with Acute and Chronic Insomnia |
| title_full_unstemmed |
Gut Microbiota Changes and Their Relationship with Inflammation in Patients with Acute and Chronic Insomnia |
| title_sort |
gut microbiota changes and their relationship with inflammation in patients with acute and chronic insomnia |
| publisher |
Dove Medical Press |
| publishDate |
2020 |
| url |
https://doaj.org/article/2e46032d1f3e4c7c87880e4420f8d670 |
| work_keys_str_mv |
AT liy gutmicrobiotachangesandtheirrelationshipwithinflammationinpatientswithacuteandchronicinsomnia AT zhangb gutmicrobiotachangesandtheirrelationshipwithinflammationinpatientswithacuteandchronicinsomnia AT zhouy gutmicrobiotachangesandtheirrelationshipwithinflammationinpatientswithacuteandchronicinsomnia AT wangd gutmicrobiotachangesandtheirrelationshipwithinflammationinpatientswithacuteandchronicinsomnia AT liux gutmicrobiotachangesandtheirrelationshipwithinflammationinpatientswithacuteandchronicinsomnia AT lil gutmicrobiotachangesandtheirrelationshipwithinflammationinpatientswithacuteandchronicinsomnia AT wangt gutmicrobiotachangesandtheirrelationshipwithinflammationinpatientswithacuteandchronicinsomnia AT zhangy gutmicrobiotachangesandtheirrelationshipwithinflammationinpatientswithacuteandchronicinsomnia AT jiangm gutmicrobiotachangesandtheirrelationshipwithinflammationinpatientswithacuteandchronicinsomnia AT tangh gutmicrobiotachangesandtheirrelationshipwithinflammationinpatientswithacuteandchronicinsomnia AT amsellv gutmicrobiotachangesandtheirrelationshipwithinflammationinpatientswithacuteandchronicinsomnia AT fanf gutmicrobiotachangesandtheirrelationshipwithinflammationinpatientswithacuteandchronicinsomnia AT hovencw gutmicrobiotachangesandtheirrelationshipwithinflammationinpatientswithacuteandchronicinsomnia |
| _version_ |
1718393615076556800 |