Smoking status and endothelial function in Japanese men
Abstract It is established that smoking is a major risk factor of atherosclerosis. Endothelial dysfunction occurs in the initial step in the pathogenesis of atherosclerosis and plays a critical role in the development of atherosclerosis. The purpose of this study was to evaluate the association betw...
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Nature Portfolio
2021
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oai:doaj.org-article:2e4cf058ea1549b1bd16db6a816848aa2021-12-02T15:08:21ZSmoking status and endothelial function in Japanese men10.1038/s41598-020-80012-x2045-2322https://doaj.org/article/2e4cf058ea1549b1bd16db6a816848aa2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80012-xhttps://doaj.org/toc/2045-2322Abstract It is established that smoking is a major risk factor of atherosclerosis. Endothelial dysfunction occurs in the initial step in the pathogenesis of atherosclerosis and plays a critical role in the development of atherosclerosis. The purpose of this study was to evaluate the association between smoking status and endothelial function in detail in men. We measured flow-mediated vasodilation (FMD) in 2209 Japanese men including 1181 men who had never smoked and 1028 current smokers. All of the participants were divided into five groups by smoking pack-years: never smoker group (= 0), light smoker group (> 0 to 10), moderate smoker group (> 10 to 20), heavy smoker group (> 20 to 30) and excessive smoker group (> 30). FMD significantly decreased in relation to pack-years (6.6 ± 3.4% in the never smoker group, 6.8 ± 3.0% in the light smoker group, 6.5 ± 2.9% in the moderate smoker group, 5.9 ± 2.9% in the heavy smoker group, and 4.9 ± 2.7% in the excessive smoker group; P < 0.001). After adjustment for age (≥ 65 years), body mass index, systolic blood pressure, low-density lipoprotein cholesterol, glucose, and year of recruitment, FMD was significantly smaller in the excessive smoker group than in the never smoker group as a reference group (OR 1.95, 95% CI 1.42 to 2.67; P < 0.001). These findings suggest that FMD decreases with an increase in the number of cigarettes smoked and that excessive smoking is associated with endothelial dysfunction. Cigarette smoking is harmful to vascular function in men who are heavy smokers.Haruki HashimotoTatsuya MaruhashiTakayuki YamajiTakahiro HaradaYiming HanYuji TakaekoYasuki KiharaKazuaki ChayamaChikara GotoYoshiki AibaraFarina Mohamad YusoffShinji KishimotoMasato KajikawaAyumu NakashimaYukihito HigashiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) |
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DOAJ |
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DOAJ |
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Medicine R Science Q |
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Medicine R Science Q Haruki Hashimoto Tatsuya Maruhashi Takayuki Yamaji Takahiro Harada Yiming Han Yuji Takaeko Yasuki Kihara Kazuaki Chayama Chikara Goto Yoshiki Aibara Farina Mohamad Yusoff Shinji Kishimoto Masato Kajikawa Ayumu Nakashima Yukihito Higashi Smoking status and endothelial function in Japanese men |
| description |
Abstract It is established that smoking is a major risk factor of atherosclerosis. Endothelial dysfunction occurs in the initial step in the pathogenesis of atherosclerosis and plays a critical role in the development of atherosclerosis. The purpose of this study was to evaluate the association between smoking status and endothelial function in detail in men. We measured flow-mediated vasodilation (FMD) in 2209 Japanese men including 1181 men who had never smoked and 1028 current smokers. All of the participants were divided into five groups by smoking pack-years: never smoker group (= 0), light smoker group (> 0 to 10), moderate smoker group (> 10 to 20), heavy smoker group (> 20 to 30) and excessive smoker group (> 30). FMD significantly decreased in relation to pack-years (6.6 ± 3.4% in the never smoker group, 6.8 ± 3.0% in the light smoker group, 6.5 ± 2.9% in the moderate smoker group, 5.9 ± 2.9% in the heavy smoker group, and 4.9 ± 2.7% in the excessive smoker group; P < 0.001). After adjustment for age (≥ 65 years), body mass index, systolic blood pressure, low-density lipoprotein cholesterol, glucose, and year of recruitment, FMD was significantly smaller in the excessive smoker group than in the never smoker group as a reference group (OR 1.95, 95% CI 1.42 to 2.67; P < 0.001). These findings suggest that FMD decreases with an increase in the number of cigarettes smoked and that excessive smoking is associated with endothelial dysfunction. Cigarette smoking is harmful to vascular function in men who are heavy smokers. |
| format |
article |
| author |
Haruki Hashimoto Tatsuya Maruhashi Takayuki Yamaji Takahiro Harada Yiming Han Yuji Takaeko Yasuki Kihara Kazuaki Chayama Chikara Goto Yoshiki Aibara Farina Mohamad Yusoff Shinji Kishimoto Masato Kajikawa Ayumu Nakashima Yukihito Higashi |
| author_facet |
Haruki Hashimoto Tatsuya Maruhashi Takayuki Yamaji Takahiro Harada Yiming Han Yuji Takaeko Yasuki Kihara Kazuaki Chayama Chikara Goto Yoshiki Aibara Farina Mohamad Yusoff Shinji Kishimoto Masato Kajikawa Ayumu Nakashima Yukihito Higashi |
| author_sort |
Haruki Hashimoto |
| title |
Smoking status and endothelial function in Japanese men |
| title_short |
Smoking status and endothelial function in Japanese men |
| title_full |
Smoking status and endothelial function in Japanese men |
| title_fullStr |
Smoking status and endothelial function in Japanese men |
| title_full_unstemmed |
Smoking status and endothelial function in Japanese men |
| title_sort |
smoking status and endothelial function in japanese men |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/2e4cf058ea1549b1bd16db6a816848aa |
| work_keys_str_mv |
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| _version_ |
1718388175364161536 |