The early stage of bacterial genome-reductive evolution in the host.

The equine-associated obligate pathogen Burkholderia mallei was developed by reductive evolution involving a substantial portion of the genome from Burkholderia pseudomallei, a free-living opportunistic pathogen. With its short history of divergence (approximately 3.5 myr), B. mallei provides an exc...

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Autores principales:	Han Song, Junghyun Hwang, Hyojeong Yi, Ricky L Ulrich, Yan Yu, William C Nierman, Heenam Stanley Kim
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2e4d5d4e5c0545f48e9639968eda1a97
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spelling	oai:doaj.org-article:2e4d5d4e5c0545f48e9639968eda1a972021-12-02T20:00:37ZThe early stage of bacterial genome-reductive evolution in the host.1553-73661553-737410.1371/journal.ppat.1000922https://doaj.org/article/2e4d5d4e5c0545f48e9639968eda1a972010-05-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20523904/pdf/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374The equine-associated obligate pathogen Burkholderia mallei was developed by reductive evolution involving a substantial portion of the genome from Burkholderia pseudomallei, a free-living opportunistic pathogen. With its short history of divergence (approximately 3.5 myr), B. mallei provides an excellent resource to study the early steps in bacterial genome reductive evolution in the host. By examining 20 genomes of B. mallei and B. pseudomallei, we found that stepwise massive expansion of IS (insertion sequence) elements ISBma1, ISBma2, and IS407A occurred during the evolution of B. mallei. Each element proliferated through the sites where its target selection preference was met. Then, ISBma1 and ISBma2 contributed to the further spread of IS407A by providing secondary insertion sites. This spread increased genomic deletions and rearrangements, which were predominantly mediated by IS407A. There were also nucleotide-level disruptions in a large number of genes. However, no significant signs of erosion were yet noted in these genes. Intriguingly, all these genomic modifications did not seriously alter the gene expression patterns inherited from B. pseudomallei. This efficient and elaborate genomic transition was enabled largely through the formation of the highly flexible IS-blended genome and the guidance by selective forces in the host. The detailed IS intervention, unveiled for the first time in this study, may represent the key component of a general mechanism for early bacterial evolution in the host.Han SongJunghyun HwangHyojeong YiRicky L UlrichYan YuWilliam C NiermanHeenam Stanley KimPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 6, Iss 5, p e1000922 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Han Song Junghyun Hwang Hyojeong Yi Ricky L Ulrich Yan Yu William C Nierman Heenam Stanley Kim The early stage of bacterial genome-reductive evolution in the host.
description	The equine-associated obligate pathogen Burkholderia mallei was developed by reductive evolution involving a substantial portion of the genome from Burkholderia pseudomallei, a free-living opportunistic pathogen. With its short history of divergence (approximately 3.5 myr), B. mallei provides an excellent resource to study the early steps in bacterial genome reductive evolution in the host. By examining 20 genomes of B. mallei and B. pseudomallei, we found that stepwise massive expansion of IS (insertion sequence) elements ISBma1, ISBma2, and IS407A occurred during the evolution of B. mallei. Each element proliferated through the sites where its target selection preference was met. Then, ISBma1 and ISBma2 contributed to the further spread of IS407A by providing secondary insertion sites. This spread increased genomic deletions and rearrangements, which were predominantly mediated by IS407A. There were also nucleotide-level disruptions in a large number of genes. However, no significant signs of erosion were yet noted in these genes. Intriguingly, all these genomic modifications did not seriously alter the gene expression patterns inherited from B. pseudomallei. This efficient and elaborate genomic transition was enabled largely through the formation of the highly flexible IS-blended genome and the guidance by selective forces in the host. The detailed IS intervention, unveiled for the first time in this study, may represent the key component of a general mechanism for early bacterial evolution in the host.
format	article
author	Han Song Junghyun Hwang Hyojeong Yi Ricky L Ulrich Yan Yu William C Nierman Heenam Stanley Kim
author_facet	Han Song Junghyun Hwang Hyojeong Yi Ricky L Ulrich Yan Yu William C Nierman Heenam Stanley Kim
author_sort	Han Song
title	The early stage of bacterial genome-reductive evolution in the host.
title_short	The early stage of bacterial genome-reductive evolution in the host.
title_full	The early stage of bacterial genome-reductive evolution in the host.
title_fullStr	The early stage of bacterial genome-reductive evolution in the host.
title_full_unstemmed	The early stage of bacterial genome-reductive evolution in the host.
title_sort	early stage of bacterial genome-reductive evolution in the host.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/2e4d5d4e5c0545f48e9639968eda1a97
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The early stage of bacterial genome-reductive evolution in the host.

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