Crosstalk Between Circulating Follicular T Helper Cells and Regulatory B Cells in Children With Extrinsic Atopic Dermatitis

Atopic dermatitis (AD) in early childhood is often the initial manifestation of allergic disease associated with high IgE. Accumulating evidences show that follicular helper T (Tfh) cells play a critical role in promoting B cell differentiation and IgE production, human regulatory B (Breg) cells par...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jinqiu Jiang, Shi Yan, Xiaoying Zhou, Jinghua Zhou, Xiaoming Bai, Qi Tan, Yunqiu Xia, Hua Wang, Xiaoyan Luo
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	atopic dermatitis regulatory B cells T follicular helper cells IL-10 immunoglobulin E Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/2e4f6ee7ca72448996c5197a6557f81b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2e4f6ee7ca72448996c5197a6557f81b
record_format	dspace
spelling	oai:doaj.org-article:2e4f6ee7ca72448996c5197a6557f81b2021-12-01T18:05:30ZCrosstalk Between Circulating Follicular T Helper Cells and Regulatory B Cells in Children With Extrinsic Atopic Dermatitis1664-322410.3389/fimmu.2021.785549https://doaj.org/article/2e4f6ee7ca72448996c5197a6557f81b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.785549/fullhttps://doaj.org/toc/1664-3224Atopic dermatitis (AD) in early childhood is often the initial manifestation of allergic disease associated with high IgE. Accumulating evidences show that follicular helper T (Tfh) cells play a critical role in promoting B cell differentiation and IgE production, human regulatory B (Breg) cells participate in immunomodulatory processes and inhibition of allergic inflammation. However, the roles and interactions between IL-10-producing Breg cells and Tfh cells in childhood AD are unclear. In this study, we found that the percentage of CD19+IL-10+ Breg cells in children with extrinsic AD was significantly lower than that in age-matched healthy controls, and that it correlated negatively with enhanced CD4+CXCR5+PD-1+ICOS+ circulating Tfh cell responses and increased disease activity; however, there was no significant correlation with serum total IgE levels. A co-culture system revealed that Breg cells from patients with extrinsic AD cannot effectively inhibit differentiation of Tfh cells in an IL-10 dependent manner. Abnormal pSTAT3 signaling induced via Toll-like receptors (TLR), but not the B-cell receptor (BCR) signaling, might contribute to the defect of Breg cells in AD. Taken together, these observations demonstrate an important role for IL-10-producing Breg cells in inhibiting Tfh cell differentiation, and suggest that they may participate in the pathogenesis of AD.Jinqiu JiangJinqiu JiangJinqiu JiangJinqiu JiangShi YanShi YanXiaoying ZhouXiaoying ZhouJinghua ZhouJinghua ZhouXiaoming BaiQi TanYunqiu XiaHua WangHua WangHua WangHua WangXiaoyan LuoXiaoyan LuoXiaoyan LuoXiaoyan LuoFrontiers Media S.A.articleatopic dermatitisregulatory B cellsT follicular helper cellsIL-10immunoglobulin EImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	atopic dermatitis regulatory B cells T follicular helper cells IL-10 immunoglobulin E Immunologic diseases. Allergy RC581-607
spellingShingle	atopic dermatitis regulatory B cells T follicular helper cells IL-10 immunoglobulin E Immunologic diseases. Allergy RC581-607 Jinqiu Jiang Jinqiu Jiang Jinqiu Jiang Jinqiu Jiang Shi Yan Shi Yan Xiaoying Zhou Xiaoying Zhou Jinghua Zhou Jinghua Zhou Xiaoming Bai Qi Tan Yunqiu Xia Hua Wang Hua Wang Hua Wang Hua Wang Xiaoyan Luo Xiaoyan Luo Xiaoyan Luo Xiaoyan Luo Crosstalk Between Circulating Follicular T Helper Cells and Regulatory B Cells in Children With Extrinsic Atopic Dermatitis
description	Atopic dermatitis (AD) in early childhood is often the initial manifestation of allergic disease associated with high IgE. Accumulating evidences show that follicular helper T (Tfh) cells play a critical role in promoting B cell differentiation and IgE production, human regulatory B (Breg) cells participate in immunomodulatory processes and inhibition of allergic inflammation. However, the roles and interactions between IL-10-producing Breg cells and Tfh cells in childhood AD are unclear. In this study, we found that the percentage of CD19+IL-10+ Breg cells in children with extrinsic AD was significantly lower than that in age-matched healthy controls, and that it correlated negatively with enhanced CD4+CXCR5+PD-1+ICOS+ circulating Tfh cell responses and increased disease activity; however, there was no significant correlation with serum total IgE levels. A co-culture system revealed that Breg cells from patients with extrinsic AD cannot effectively inhibit differentiation of Tfh cells in an IL-10 dependent manner. Abnormal pSTAT3 signaling induced via Toll-like receptors (TLR), but not the B-cell receptor (BCR) signaling, might contribute to the defect of Breg cells in AD. Taken together, these observations demonstrate an important role for IL-10-producing Breg cells in inhibiting Tfh cell differentiation, and suggest that they may participate in the pathogenesis of AD.
format	article
author	Jinqiu Jiang Jinqiu Jiang Jinqiu Jiang Jinqiu Jiang Shi Yan Shi Yan Xiaoying Zhou Xiaoying Zhou Jinghua Zhou Jinghua Zhou Xiaoming Bai Qi Tan Yunqiu Xia Hua Wang Hua Wang Hua Wang Hua Wang Xiaoyan Luo Xiaoyan Luo Xiaoyan Luo Xiaoyan Luo
author_facet	Jinqiu Jiang Jinqiu Jiang Jinqiu Jiang Jinqiu Jiang Shi Yan Shi Yan Xiaoying Zhou Xiaoying Zhou Jinghua Zhou Jinghua Zhou Xiaoming Bai Qi Tan Yunqiu Xia Hua Wang Hua Wang Hua Wang Hua Wang Xiaoyan Luo Xiaoyan Luo Xiaoyan Luo Xiaoyan Luo
author_sort	Jinqiu Jiang
title	Crosstalk Between Circulating Follicular T Helper Cells and Regulatory B Cells in Children With Extrinsic Atopic Dermatitis
title_short	Crosstalk Between Circulating Follicular T Helper Cells and Regulatory B Cells in Children With Extrinsic Atopic Dermatitis
title_full	Crosstalk Between Circulating Follicular T Helper Cells and Regulatory B Cells in Children With Extrinsic Atopic Dermatitis
title_fullStr	Crosstalk Between Circulating Follicular T Helper Cells and Regulatory B Cells in Children With Extrinsic Atopic Dermatitis
title_full_unstemmed	Crosstalk Between Circulating Follicular T Helper Cells and Regulatory B Cells in Children With Extrinsic Atopic Dermatitis
title_sort	crosstalk between circulating follicular t helper cells and regulatory b cells in children with extrinsic atopic dermatitis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/2e4f6ee7ca72448996c5197a6557f81b
work_keys_str_mv	AT jinqiujiang crosstalkbetweencirculatingfollicularthelpercellsandregulatorybcellsinchildrenwithextrinsicatopicdermatitis AT jinqiujiang crosstalkbetweencirculatingfollicularthelpercellsandregulatorybcellsinchildrenwithextrinsicatopicdermatitis AT jinqiujiang crosstalkbetweencirculatingfollicularthelpercellsandregulatorybcellsinchildrenwithextrinsicatopicdermatitis AT jinqiujiang crosstalkbetweencirculatingfollicularthelpercellsandregulatorybcellsinchildrenwithextrinsicatopicdermatitis AT shiyan crosstalkbetweencirculatingfollicularthelpercellsandregulatorybcellsinchildrenwithextrinsicatopicdermatitis AT shiyan crosstalkbetweencirculatingfollicularthelpercellsandregulatorybcellsinchildrenwithextrinsicatopicdermatitis AT xiaoyingzhou crosstalkbetweencirculatingfollicularthelpercellsandregulatorybcellsinchildrenwithextrinsicatopicdermatitis AT xiaoyingzhou crosstalkbetweencirculatingfollicularthelpercellsandregulatorybcellsinchildrenwithextrinsicatopicdermatitis AT jinghuazhou crosstalkbetweencirculatingfollicularthelpercellsandregulatorybcellsinchildrenwithextrinsicatopicdermatitis AT jinghuazhou crosstalkbetweencirculatingfollicularthelpercellsandregulatorybcellsinchildrenwithextrinsicatopicdermatitis AT xiaomingbai crosstalkbetweencirculatingfollicularthelpercellsandregulatorybcellsinchildrenwithextrinsicatopicdermatitis AT qitan crosstalkbetweencirculatingfollicularthelpercellsandregulatorybcellsinchildrenwithextrinsicatopicdermatitis AT yunqiuxia crosstalkbetweencirculatingfollicularthelpercellsandregulatorybcellsinchildrenwithextrinsicatopicdermatitis AT huawang crosstalkbetweencirculatingfollicularthelpercellsandregulatorybcellsinchildrenwithextrinsicatopicdermatitis AT huawang crosstalkbetweencirculatingfollicularthelpercellsandregulatorybcellsinchildrenwithextrinsicatopicdermatitis AT huawang crosstalkbetweencirculatingfollicularthelpercellsandregulatorybcellsinchildrenwithextrinsicatopicdermatitis AT huawang crosstalkbetweencirculatingfollicularthelpercellsandregulatorybcellsinchildrenwithextrinsicatopicdermatitis AT xiaoyanluo crosstalkbetweencirculatingfollicularthelpercellsandregulatorybcellsinchildrenwithextrinsicatopicdermatitis AT xiaoyanluo crosstalkbetweencirculatingfollicularthelpercellsandregulatorybcellsinchildrenwithextrinsicatopicdermatitis AT xiaoyanluo crosstalkbetweencirculatingfollicularthelpercellsandregulatorybcellsinchildrenwithextrinsicatopicdermatitis AT xiaoyanluo crosstalkbetweencirculatingfollicularthelpercellsandregulatorybcellsinchildrenwithextrinsicatopicdermatitis
_version_	1718404740928241664

Crosstalk Between Circulating Follicular T Helper Cells and Regulatory B Cells in Children With Extrinsic Atopic Dermatitis

Ejemplares similares