ASSOCIATION OF HYPERDIPLOIDY WITH REMISSION STATUS IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA AFTER INDUCTION THERAPY

Objective: To determine the frequency of hyperdiploidy in childhood acute lymphoblastic leukemia (ALL) and its association with remission status after induction therapy. Study Design: Observational study. Place and Duration of Study: Department of Haematology, Armed Forces Institute of Patholo...

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Autores principales:	Saqib Hussain Korejo, Ch. Altaf Hussain, Tariq Ghafoor, Hamid Saeed Malik, Ayesha Khurshid, Rafia Mahmood
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2019
Materias:	acute lymphoblastic leukemia complete haematological remission (chr) Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2e51df00fde1429398b2238ea847cd99
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spelling	oai:doaj.org-article:2e51df00fde1429398b2238ea847cd992021-11-12T04:27:56ZASSOCIATION OF HYPERDIPLOIDY WITH REMISSION STATUS IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA AFTER INDUCTION THERAPY0030-96482411-8842https://doaj.org/article/2e51df00fde1429398b2238ea847cd992019-06-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/3053/2285https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the frequency of hyperdiploidy in childhood acute lymphoblastic leukemia (ALL) and its association with remission status after induction therapy. Study Design: Observational study. Place and Duration of Study: Department of Haematology, Armed Forces Institute of Pathology (AFIP) and Pediatric Oncology Department Combined Military Hospital (CMH) Rawalpindi, from Apr 2017 to Apr 2018. Patients and Methods: All diagnosed cases of ALL between 1-12 years of age were selected by convenient nonprobability sampling. All other cases of leukemias including patients of acute undifferentiated leukaemia, acute myeloid leukaemia and patients of ALL who did not yield successful cytogenetic culture or those who died during the induction therapy were excluded from the study. Diagnosis of ALL was done on the basis of morphology, cytochemistry, immunophenotyping and cytogenetics. Cytogenetic analysis was done by using conventional Giemsa banding. Karyotypes were interpreted using the International System for Human Cytogenetic Nomenclature (ISCN). On the basis of cytogenetics two groups were made one with hyperdiploidy and another without hyperdiploidy. Hyperdiploidy was defined as chromosomes >46. All patients of childhood ALL were treated with ‘UK ALL 2011’ protocol and their remission status was assessed after 1 month of induction therapy by bone marrow examination. Remission status of 2 groups of ALL with and without hyperdiploidy were compared by using chi square test Results: Out of total 80 patients of ALL, 62 (77.5%) yielding successful cytogenetic culture were included in the study. Mean age at diagnosis was 5.6 ± 2.9 years and male to female ratio was 2.4:1. Analytical immunocytometry revealed 58 (93.5%) as B-ALL while 4 (6.55%) were T-ALL. Hyperdiploidy was detected in 19 (30.6%) and t (9:22) (q34:31) in 1 (1.6%). In all other patients no cytogenetic abnormality was detected. Out of 62 patients, Overall complete haematological remission (CHR) was achieved in 47 (75.8%). Out of 19, patients with hyperdiploidy 18 (94.7%) achieved CHR, as compared to other group without hyperdiploidy in which 29 (67.4%) achieved CHR. The difference was statistically significant (p-value 0.021). Conclusion: Remission rate was 94.7% in patients of childhood ALL with hyperdiploidy. Patients with hyperdiploidy achieve higher CHR rate as compared to patients without hyperdiploidy.Saqib Hussain KorejoCh. Altaf HussainTariq GhafoorHamid Saeed MalikAyesha KhurshidRafia MahmoodArmy Medical College Rawalpindiarticleacute lymphoblastic leukemiacomplete haematological remission (chr)MedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 69, Iss 3, Pp 677-680 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	acute lymphoblastic leukemia complete haematological remission (chr) Medicine R Medicine (General) R5-920
spellingShingle	acute lymphoblastic leukemia complete haematological remission (chr) Medicine R Medicine (General) R5-920 Saqib Hussain Korejo Ch. Altaf Hussain Tariq Ghafoor Hamid Saeed Malik Ayesha Khurshid Rafia Mahmood ASSOCIATION OF HYPERDIPLOIDY WITH REMISSION STATUS IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA AFTER INDUCTION THERAPY
description	Objective: To determine the frequency of hyperdiploidy in childhood acute lymphoblastic leukemia (ALL) and its association with remission status after induction therapy. Study Design: Observational study. Place and Duration of Study: Department of Haematology, Armed Forces Institute of Pathology (AFIP) and Pediatric Oncology Department Combined Military Hospital (CMH) Rawalpindi, from Apr 2017 to Apr 2018. Patients and Methods: All diagnosed cases of ALL between 1-12 years of age were selected by convenient nonprobability sampling. All other cases of leukemias including patients of acute undifferentiated leukaemia, acute myeloid leukaemia and patients of ALL who did not yield successful cytogenetic culture or those who died during the induction therapy were excluded from the study. Diagnosis of ALL was done on the basis of morphology, cytochemistry, immunophenotyping and cytogenetics. Cytogenetic analysis was done by using conventional Giemsa banding. Karyotypes were interpreted using the International System for Human Cytogenetic Nomenclature (ISCN). On the basis of cytogenetics two groups were made one with hyperdiploidy and another without hyperdiploidy. Hyperdiploidy was defined as chromosomes >46. All patients of childhood ALL were treated with ‘UK ALL 2011’ protocol and their remission status was assessed after 1 month of induction therapy by bone marrow examination. Remission status of 2 groups of ALL with and without hyperdiploidy were compared by using chi square test Results: Out of total 80 patients of ALL, 62 (77.5%) yielding successful cytogenetic culture were included in the study. Mean age at diagnosis was 5.6 ± 2.9 years and male to female ratio was 2.4:1. Analytical immunocytometry revealed 58 (93.5%) as B-ALL while 4 (6.55%) were T-ALL. Hyperdiploidy was detected in 19 (30.6%) and t (9:22) (q34:31) in 1 (1.6%). In all other patients no cytogenetic abnormality was detected. Out of 62 patients, Overall complete haematological remission (CHR) was achieved in 47 (75.8%). Out of 19, patients with hyperdiploidy 18 (94.7%) achieved CHR, as compared to other group without hyperdiploidy in which 29 (67.4%) achieved CHR. The difference was statistically significant (p-value 0.021). Conclusion: Remission rate was 94.7% in patients of childhood ALL with hyperdiploidy. Patients with hyperdiploidy achieve higher CHR rate as compared to patients without hyperdiploidy.
format	article
author	Saqib Hussain Korejo Ch. Altaf Hussain Tariq Ghafoor Hamid Saeed Malik Ayesha Khurshid Rafia Mahmood
author_facet	Saqib Hussain Korejo Ch. Altaf Hussain Tariq Ghafoor Hamid Saeed Malik Ayesha Khurshid Rafia Mahmood
author_sort	Saqib Hussain Korejo
title	ASSOCIATION OF HYPERDIPLOIDY WITH REMISSION STATUS IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA AFTER INDUCTION THERAPY
title_short	ASSOCIATION OF HYPERDIPLOIDY WITH REMISSION STATUS IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA AFTER INDUCTION THERAPY
title_full	ASSOCIATION OF HYPERDIPLOIDY WITH REMISSION STATUS IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA AFTER INDUCTION THERAPY
title_fullStr	ASSOCIATION OF HYPERDIPLOIDY WITH REMISSION STATUS IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA AFTER INDUCTION THERAPY
title_full_unstemmed	ASSOCIATION OF HYPERDIPLOIDY WITH REMISSION STATUS IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA AFTER INDUCTION THERAPY
title_sort	association of hyperdiploidy with remission status in childhood acute lymphoblastic leukemia after induction therapy
publisher	Army Medical College Rawalpindi
publishDate	2019
url	https://doaj.org/article/2e51df00fde1429398b2238ea847cd99
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ASSOCIATION OF HYPERDIPLOIDY WITH REMISSION STATUS IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA AFTER INDUCTION THERAPY

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