Effect of Statins (Zocor) on Oxygen-Dependent Processes in Muscle Tissue and Erythrocytes in Animals with Hypercholesterolemia

Background. Statin therapy may be accompanied by a toxic effect on skeletal muscle and liver cells, the molecular mechanisms of which have not yet been fully understood.Aim. To clarify the peculiarities of changes in the oxygen transport function of erythrocytes and antioxidant mechanisms in erythro...

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Autores principales:	E. V. Vinogradova, Z. I. Mikashinovich, E. S. Belousova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2019
Materias:	statins dyslipidemia side effects erythrocytes muscle tissue myopathy antioxidant system Science Q
Acceso en línea:	https://doaj.org/article/2e53f820e2e242b982f891c95dfbcc99
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spelling	oai:doaj.org-article:2e53f820e2e242b982f891c95dfbcc992021-11-23T06:14:42ZEffect of Statins (Zocor) on Oxygen-Dependent Processes in Muscle Tissue and Erythrocytes in Animals with Hypercholesterolemia2541-94202587-959610.29413/ABS.2019-4.3.14https://doaj.org/article/2e53f820e2e242b982f891c95dfbcc992019-07-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2092https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background. Statin therapy may be accompanied by a toxic effect on skeletal muscle and liver cells, the molecular mechanisms of which have not yet been fully understood.Aim. To clarify the peculiarities of changes in the oxygen transport function of erythrocytes and antioxidant mechanisms in erythrocytes and muscles of animals with prolonged administration of statins (simvastatin).Materials and methods. The study was conducted on outbred male rats, which during the experiment were randomly assigned to following groups: the control group contained animals on a common ration of the vivarium, the group of comparison – animals with induced hypercholesterolemia, the main group – animals with induced hypercholesterolemia treated with simvastatin. In erythrocytes and muscle tissue of animals, indicators characterizing the state of antioxidant defense and carbohydrate metabolism were determined.The results. The experiment showed that the administration of simvastatin to animals was characterized by aggravation of hypoxia due to hypercholesterolemia, as indicated by a sharp increase in the concentration of 2,3-BPG and lactate in erythrocytes of animals, as well as a significant decrease in the activity of G6PD. In the muscle tissue of animals, there was a decrease in the concentration of pyruvic acid and lactate relative to the comparison group, which indicates their intensive participation in metabolic processes.Conclusion. Based on the data obtained, it can be assumed that the peculiarity of the action of statins in erythrocytes is the increased oxygen delivery to the tissues, which in muscles was accompanied by a decrease in the level of oxidized products. At the same time, against the background of the use of statins, despite the positive direction of adaptive reactions, signs of oxidative stress remain, which is documented by the imbalance of the SOD-catalase system and a decrease in the activity of glutathione-dependent reactionsE. V. VinogradovaZ. I. MikashinovichE. S. BelousovaScientific Сentre for Family Health and Human Reproduction Problemsarticlestatinsdyslipidemiaside effectserythrocytesmuscle tissuemyopathyantioxidant systemScienceQRUActa Biomedica Scientifica, Vol 4, Iss 3, Pp 110-116 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	statins dyslipidemia side effects erythrocytes muscle tissue myopathy antioxidant system Science Q
spellingShingle	statins dyslipidemia side effects erythrocytes muscle tissue myopathy antioxidant system Science Q E. V. Vinogradova Z. I. Mikashinovich E. S. Belousova Effect of Statins (Zocor) on Oxygen-Dependent Processes in Muscle Tissue and Erythrocytes in Animals with Hypercholesterolemia
description	Background. Statin therapy may be accompanied by a toxic effect on skeletal muscle and liver cells, the molecular mechanisms of which have not yet been fully understood.Aim. To clarify the peculiarities of changes in the oxygen transport function of erythrocytes and antioxidant mechanisms in erythrocytes and muscles of animals with prolonged administration of statins (simvastatin).Materials and methods. The study was conducted on outbred male rats, which during the experiment were randomly assigned to following groups: the control group contained animals on a common ration of the vivarium, the group of comparison – animals with induced hypercholesterolemia, the main group – animals with induced hypercholesterolemia treated with simvastatin. In erythrocytes and muscle tissue of animals, indicators characterizing the state of antioxidant defense and carbohydrate metabolism were determined.The results. The experiment showed that the administration of simvastatin to animals was characterized by aggravation of hypoxia due to hypercholesterolemia, as indicated by a sharp increase in the concentration of 2,3-BPG and lactate in erythrocytes of animals, as well as a significant decrease in the activity of G6PD. In the muscle tissue of animals, there was a decrease in the concentration of pyruvic acid and lactate relative to the comparison group, which indicates their intensive participation in metabolic processes.Conclusion. Based on the data obtained, it can be assumed that the peculiarity of the action of statins in erythrocytes is the increased oxygen delivery to the tissues, which in muscles was accompanied by a decrease in the level of oxidized products. At the same time, against the background of the use of statins, despite the positive direction of adaptive reactions, signs of oxidative stress remain, which is documented by the imbalance of the SOD-catalase system and a decrease in the activity of glutathione-dependent reactions
format	article
author	E. V. Vinogradova Z. I. Mikashinovich E. S. Belousova
author_facet	E. V. Vinogradova Z. I. Mikashinovich E. S. Belousova
author_sort	E. V. Vinogradova
title	Effect of Statins (Zocor) on Oxygen-Dependent Processes in Muscle Tissue and Erythrocytes in Animals with Hypercholesterolemia
title_short	Effect of Statins (Zocor) on Oxygen-Dependent Processes in Muscle Tissue and Erythrocytes in Animals with Hypercholesterolemia
title_full	Effect of Statins (Zocor) on Oxygen-Dependent Processes in Muscle Tissue and Erythrocytes in Animals with Hypercholesterolemia
title_fullStr	Effect of Statins (Zocor) on Oxygen-Dependent Processes in Muscle Tissue and Erythrocytes in Animals with Hypercholesterolemia
title_full_unstemmed	Effect of Statins (Zocor) on Oxygen-Dependent Processes in Muscle Tissue and Erythrocytes in Animals with Hypercholesterolemia
title_sort	effect of statins (zocor) on oxygen-dependent processes in muscle tissue and erythrocytes in animals with hypercholesterolemia
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2019
url	https://doaj.org/article/2e53f820e2e242b982f891c95dfbcc99
work_keys_str_mv	AT evvinogradova effectofstatinszocoronoxygendependentprocessesinmuscletissueanderythrocytesinanimalswithhypercholesterolemia AT zimikashinovich effectofstatinszocoronoxygendependentprocessesinmuscletissueanderythrocytesinanimalswithhypercholesterolemia AT esbelousova effectofstatinszocoronoxygendependentprocessesinmuscletissueanderythrocytesinanimalswithhypercholesterolemia
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Effect of Statins (Zocor) on Oxygen-Dependent Processes in Muscle Tissue and Erythrocytes in Animals with Hypercholesterolemia

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