Effects of enriched physical and social environments on motor performance, associative learning, and hippocampal neurogenesis in mice.

We have studied the motor abilities and associative learning capabilities of adult mice placed in different enriched environments. Three-month-old animals were maintained for a month alone (AL), alone in a physically enriched environment (PHY), and, finally, in groups in the absence (SO) or presence...

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Autores principales:	Noelia Madroñal, Cristina López-Aracil, Alejandra Rangel, José A del Río, José M Delgado-García, Agnès Gruart
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2e60a0af1f4c42378d3205cddd32a294
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spelling	oai:doaj.org-article:2e60a0af1f4c42378d3205cddd32a2942021-12-02T20:20:47ZEffects of enriched physical and social environments on motor performance, associative learning, and hippocampal neurogenesis in mice.1932-620310.1371/journal.pone.0011130https://doaj.org/article/2e60a0af1f4c42378d3205cddd32a2942010-06-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20559565/?tool=EBIhttps://doaj.org/toc/1932-6203We have studied the motor abilities and associative learning capabilities of adult mice placed in different enriched environments. Three-month-old animals were maintained for a month alone (AL), alone in a physically enriched environment (PHY), and, finally, in groups in the absence (SO) or presence (SOPHY) of an enriched environment. The animals' capabilities were subsequently checked in the rotarod test, and for classical and instrumental learning. The PHY and SOPHY groups presented better performances in the rotarod test and in the acquisition of the instrumental learning task. In contrast, no significant differences between groups were observed for classical eyeblink conditioning. The four groups presented similar increases in the strength of field EPSPs (fEPSPs) evoked at the hippocampal CA3-CA1 synapse across classical conditioning sessions, with no significant differences between groups. These trained animals were pulse-injected with bromodeoxyuridine (BrdU) to determine hippocampal neurogenesis. No significant differences were found in the number of NeuN/BrdU double-labeled neurons. We repeated the same BrdU study in one-month-old mice raised for an additional month in the above-mentioned four different environments. These animals were not submitted to rotarod or conditioned tests. Non-trained PHY and SOPHY groups presented more neurogenesis than the other two groups. Thus, neurogenesis seems to be related to physical enrichment at early ages, but not to learning acquisition in adult mice.Noelia MadroñalCristina López-AracilAlejandra RangelJosé A del RíoJosé M Delgado-GarcíaAgnès GruartPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 6, p e11130 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Noelia Madroñal Cristina López-Aracil Alejandra Rangel José A del Río José M Delgado-García Agnès Gruart Effects of enriched physical and social environments on motor performance, associative learning, and hippocampal neurogenesis in mice.
description	We have studied the motor abilities and associative learning capabilities of adult mice placed in different enriched environments. Three-month-old animals were maintained for a month alone (AL), alone in a physically enriched environment (PHY), and, finally, in groups in the absence (SO) or presence (SOPHY) of an enriched environment. The animals' capabilities were subsequently checked in the rotarod test, and for classical and instrumental learning. The PHY and SOPHY groups presented better performances in the rotarod test and in the acquisition of the instrumental learning task. In contrast, no significant differences between groups were observed for classical eyeblink conditioning. The four groups presented similar increases in the strength of field EPSPs (fEPSPs) evoked at the hippocampal CA3-CA1 synapse across classical conditioning sessions, with no significant differences between groups. These trained animals were pulse-injected with bromodeoxyuridine (BrdU) to determine hippocampal neurogenesis. No significant differences were found in the number of NeuN/BrdU double-labeled neurons. We repeated the same BrdU study in one-month-old mice raised for an additional month in the above-mentioned four different environments. These animals were not submitted to rotarod or conditioned tests. Non-trained PHY and SOPHY groups presented more neurogenesis than the other two groups. Thus, neurogenesis seems to be related to physical enrichment at early ages, but not to learning acquisition in adult mice.
format	article
author	Noelia Madroñal Cristina López-Aracil Alejandra Rangel José A del Río José M Delgado-García Agnès Gruart
author_facet	Noelia Madroñal Cristina López-Aracil Alejandra Rangel José A del Río José M Delgado-García Agnès Gruart
author_sort	Noelia Madroñal
title	Effects of enriched physical and social environments on motor performance, associative learning, and hippocampal neurogenesis in mice.
title_short	Effects of enriched physical and social environments on motor performance, associative learning, and hippocampal neurogenesis in mice.
title_full	Effects of enriched physical and social environments on motor performance, associative learning, and hippocampal neurogenesis in mice.
title_fullStr	Effects of enriched physical and social environments on motor performance, associative learning, and hippocampal neurogenesis in mice.
title_full_unstemmed	Effects of enriched physical and social environments on motor performance, associative learning, and hippocampal neurogenesis in mice.
title_sort	effects of enriched physical and social environments on motor performance, associative learning, and hippocampal neurogenesis in mice.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/2e60a0af1f4c42378d3205cddd32a294
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Effects of enriched physical and social environments on motor performance, associative learning, and hippocampal neurogenesis in mice.

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