Extra-forebrain impact of antipsychotics indicated by c-Fos or FosB/ΔFosB expression: A minireview

It is apparent that the c-Fos and FosB/ΔFosB immunohistochemistry has generally become a useful tool for determining the different antipsychotic (AP) drugs activities in the brain. It is also noteworthy that there are no spatial limits, while to the extent of their identification over the whole brai...

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Autores principales:	Kiss Alexander, Osacka Jana
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2021
Materias:	antipsychotics c-fos fosb/δfosb brain extra-forebrain structures Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/2e61a38405c047b9bfac6dcc2acc8efe
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id	oai:doaj.org-article:2e61a38405c047b9bfac6dcc2acc8efe
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spelling	oai:doaj.org-article:2e61a38405c047b9bfac6dcc2acc8efe2021-12-02T16:40:25ZExtra-forebrain impact of antipsychotics indicated by c-Fos or FosB/ΔFosB expression: A minireview1336-032910.2478/enr-2021-0013https://doaj.org/article/2e61a38405c047b9bfac6dcc2acc8efe2021-04-01T00:00:00Zhttps://doi.org/10.2478/enr-2021-0013https://doaj.org/toc/1336-0329It is apparent that the c-Fos and FosB/ΔFosB immunohistochemistry has generally become a useful tool for determining the different antipsychotic (AP) drugs activities in the brain. It is also noteworthy that there are no spatial limits, while to the extent of their identification over the whole brain axis. In addition, they can be in a parallel manner utilized in the unmasking of the brain cell phenotype character activated by APs and by this way also to identify the possible brain circuits underwent to the APs action. However, up to date, the number of APs involved in the extra-striatal studies is still limited, what prevents the possibility to fully understand their extra-striatal effects as a complex as well as differentiate their extra-striatal impact in qualitative and quantitative dimensions. Actually, it is very believable that more and more anatomical/functional knowledge might bring new insights into the APs extra-striatal actions by identifying new region-specific activities of APs as well as novel cellular targets affected by APs, which might reveal more details of their possible side effects of the extra-striatal origin.Kiss AlexanderOsacka JanaSciendoarticleantipsychoticsc-fosfosb/δfosbbrain extra-forebrain structuresDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Regulations, Vol 55, Iss 2, Pp 120-130 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antipsychotics c-fos fosb/δfosb brain extra-forebrain structures Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	antipsychotics c-fos fosb/δfosb brain extra-forebrain structures Diseases of the endocrine glands. Clinical endocrinology RC648-665 Kiss Alexander Osacka Jana Extra-forebrain impact of antipsychotics indicated by c-Fos or FosB/ΔFosB expression: A minireview
description	It is apparent that the c-Fos and FosB/ΔFosB immunohistochemistry has generally become a useful tool for determining the different antipsychotic (AP) drugs activities in the brain. It is also noteworthy that there are no spatial limits, while to the extent of their identification over the whole brain axis. In addition, they can be in a parallel manner utilized in the unmasking of the brain cell phenotype character activated by APs and by this way also to identify the possible brain circuits underwent to the APs action. However, up to date, the number of APs involved in the extra-striatal studies is still limited, what prevents the possibility to fully understand their extra-striatal effects as a complex as well as differentiate their extra-striatal impact in qualitative and quantitative dimensions. Actually, it is very believable that more and more anatomical/functional knowledge might bring new insights into the APs extra-striatal actions by identifying new region-specific activities of APs as well as novel cellular targets affected by APs, which might reveal more details of their possible side effects of the extra-striatal origin.
format	article
author	Kiss Alexander Osacka Jana
author_facet	Kiss Alexander Osacka Jana
author_sort	Kiss Alexander
title	Extra-forebrain impact of antipsychotics indicated by c-Fos or FosB/ΔFosB expression: A minireview
title_short	Extra-forebrain impact of antipsychotics indicated by c-Fos or FosB/ΔFosB expression: A minireview
title_full	Extra-forebrain impact of antipsychotics indicated by c-Fos or FosB/ΔFosB expression: A minireview
title_fullStr	Extra-forebrain impact of antipsychotics indicated by c-Fos or FosB/ΔFosB expression: A minireview
title_full_unstemmed	Extra-forebrain impact of antipsychotics indicated by c-Fos or FosB/ΔFosB expression: A minireview
title_sort	extra-forebrain impact of antipsychotics indicated by c-fos or fosb/δfosb expression: a minireview
publisher	Sciendo
publishDate	2021
url	https://doaj.org/article/2e61a38405c047b9bfac6dcc2acc8efe
work_keys_str_mv	AT kissalexander extraforebrainimpactofantipsychoticsindicatedbycfosorfosbdfosbexpressionaminireview AT osackajana extraforebrainimpactofantipsychoticsindicatedbycfosorfosbdfosbexpressionaminireview
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Extra-forebrain impact of antipsychotics indicated by c-Fos or FosB/ΔFosB expression: A minireview

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