New Aspects of Ultrasound-Mediated Targeted Delivery and Therapy for Cancer

Yuhang Tian,* Zhao Liu,* Haoyan Tan, Jiahui Hou, Xin Wen, Fan Yang, Wen Cheng Department of Ultrasound, Harbin Medical University Cancer Hospital, Harbin 150080, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wen ChengDepartment of Ultrasound, Harb...

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Autores principales:	Tian Y, Liu Z, Tan H, Hou J, Wen X, Yang F, Cheng W
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	ultrasound targeted delivery immunotherapy gene therapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2e62181111d44291a94540f5a7b587f3
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spelling	oai:doaj.org-article:2e62181111d44291a94540f5a7b587f32021-12-02T05:10:20ZNew Aspects of Ultrasound-Mediated Targeted Delivery and Therapy for Cancer1178-2013https://doaj.org/article/2e62181111d44291a94540f5a7b587f32020-01-01T00:00:00Zhttps://www.dovepress.com/new-aspects-of-ultrasound-mediated-targeted-delivery-and-therapy-for-c-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yuhang Tian,* Zhao Liu,* Haoyan Tan, Jiahui Hou, Xin Wen, Fan Yang, Wen Cheng Department of Ultrasound, Harbin Medical University Cancer Hospital, Harbin 150080, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wen ChengDepartment of Ultrasound, Harbin Medical University Cancer Hospital, 150 Haping Road, Nangang District, Harbin 150080, People’s Republic of ChinaTel +86 13313677182Email chengwen69@yahoo.comAbstract: Ultrasound-mediated targeted delivery (UMTD), a novel delivery modality of therapeutic materials based on ultrasound, shows great potential in biomedical applications. By coupling ultrasound contrast agents with therapeutic materials, UMTD combines the advantages of ultrasound imaging and carrier, which benefit deep tissue penetration and high concentration aggregation. In this paper we introduced recent advances in ultrasound contrast agents and applications in tumor therapy. Ultrasound contrast agents were categorized by their functions, mainly including thermosensitive, pH-sensitive and photosensitive ultrasound contrast agents. The various applications of UMTD in tumor treatment were summarized as follows: drug therapy, transfection of anti-oncogene, RNA interference, vaccine immunotherapy, monoclonal antibody immunotherapy, adoptive cellular immunotherapy, cytokine immunotherapy, and so on. In the end, we elaborated on the current challenges and provided perspectives of UMTD for clinical applications.Keywords: ultrasound, targeted delivery, immunotherapy, gene therapyTian YLiu ZTan HHou JWen XYang FCheng WDove Medical Pressarticleultrasoundtargeted deliveryimmunotherapygene therapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 401-418 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	ultrasound targeted delivery immunotherapy gene therapy Medicine (General) R5-920
spellingShingle	ultrasound targeted delivery immunotherapy gene therapy Medicine (General) R5-920 Tian Y Liu Z Tan H Hou J Wen X Yang F Cheng W New Aspects of Ultrasound-Mediated Targeted Delivery and Therapy for Cancer
description	Yuhang Tian,* Zhao Liu,* Haoyan Tan, Jiahui Hou, Xin Wen, Fan Yang, Wen Cheng Department of Ultrasound, Harbin Medical University Cancer Hospital, Harbin 150080, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wen ChengDepartment of Ultrasound, Harbin Medical University Cancer Hospital, 150 Haping Road, Nangang District, Harbin 150080, People’s Republic of ChinaTel +86 13313677182Email chengwen69@yahoo.comAbstract: Ultrasound-mediated targeted delivery (UMTD), a novel delivery modality of therapeutic materials based on ultrasound, shows great potential in biomedical applications. By coupling ultrasound contrast agents with therapeutic materials, UMTD combines the advantages of ultrasound imaging and carrier, which benefit deep tissue penetration and high concentration aggregation. In this paper we introduced recent advances in ultrasound contrast agents and applications in tumor therapy. Ultrasound contrast agents were categorized by their functions, mainly including thermosensitive, pH-sensitive and photosensitive ultrasound contrast agents. The various applications of UMTD in tumor treatment were summarized as follows: drug therapy, transfection of anti-oncogene, RNA interference, vaccine immunotherapy, monoclonal antibody immunotherapy, adoptive cellular immunotherapy, cytokine immunotherapy, and so on. In the end, we elaborated on the current challenges and provided perspectives of UMTD for clinical applications.Keywords: ultrasound, targeted delivery, immunotherapy, gene therapy
format	article
author	Tian Y Liu Z Tan H Hou J Wen X Yang F Cheng W
author_facet	Tian Y Liu Z Tan H Hou J Wen X Yang F Cheng W
author_sort	Tian Y
title	New Aspects of Ultrasound-Mediated Targeted Delivery and Therapy for Cancer
title_short	New Aspects of Ultrasound-Mediated Targeted Delivery and Therapy for Cancer
title_full	New Aspects of Ultrasound-Mediated Targeted Delivery and Therapy for Cancer
title_fullStr	New Aspects of Ultrasound-Mediated Targeted Delivery and Therapy for Cancer
title_full_unstemmed	New Aspects of Ultrasound-Mediated Targeted Delivery and Therapy for Cancer
title_sort	new aspects of ultrasound-mediated targeted delivery and therapy for cancer
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/2e62181111d44291a94540f5a7b587f3
work_keys_str_mv	AT tiany newaspectsofultrasoundmediatedtargeteddeliveryandtherapyforcancer AT liuz newaspectsofultrasoundmediatedtargeteddeliveryandtherapyforcancer AT tanh newaspectsofultrasoundmediatedtargeteddeliveryandtherapyforcancer AT houj newaspectsofultrasoundmediatedtargeteddeliveryandtherapyforcancer AT wenx newaspectsofultrasoundmediatedtargeteddeliveryandtherapyforcancer AT yangf newaspectsofultrasoundmediatedtargeteddeliveryandtherapyforcancer AT chengw newaspectsofultrasoundmediatedtargeteddeliveryandtherapyforcancer
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New Aspects of Ultrasound-Mediated Targeted Delivery and Therapy for Cancer

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