aflN Is Involved in the Biosynthesis of Aflatoxin and Conidiation in Aspergillus flavus

Aspergillus flavus poses a threat to society economy and public health due to aflatoxin production. aflN is a gene located in the aflatoxin gene cluster, but the function of AflN is undefined in Aspergillus flavus. In this study, aflN...

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Autores principales:	Kunzhi Jia, Lijuan Yan, Yipu Jia, Shuting Xu, Zhaoqi Yan, Shihua Wang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Aspergillus flavus</i> AflN aflatoxin conidiation Medicine R
Acceso en línea:	https://doaj.org/article/2e636639075a49c3a9b75b5ed60d5300
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id	oai:doaj.org-article:2e636639075a49c3a9b75b5ed60d5300
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spelling	oai:doaj.org-article:2e636639075a49c3a9b75b5ed60d53002021-11-25T19:09:14Z<i>aflN</i> Is Involved in the Biosynthesis of Aflatoxin and Conidiation in <i>Aspergillus flavus</i>10.3390/toxins131108312072-6651https://doaj.org/article/2e636639075a49c3a9b75b5ed60d53002021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6651/13/11/831https://doaj.org/toc/2072-6651<i>Aspergillus flavus</i> poses a threat to society economy and public health due to aflatoxin production. <i>aflN</i> is a gene located in the aflatoxin gene cluster, but the function of AflN is undefined in <i>Aspergillus flavus</i>. In this study, <i>aflN</i> is knocked out and overexpressed to study the function of AflN. The results indicated that the loss of AflN leads to the defect of aflatoxin biosynthesis. AflN is also found to play a role in conidiation but not hyphal growth and sclerotia development. Moreover, AlfN is related to the response to environmental oxidative stress and intracellular levels of reactive oxygen species. At last, AflN is involved in the pathogenicity of <i>Aspergillus flavus</i> to host. These results suggested that AflN played important roles in aflatoxin biosynthesis, conidiation and reactive oxygen species generation in <i>Aspergillus flavus</i>, which will be helpful for the understanding of <i>aflN</i> function, and will be beneficial to the prevention and control of <i>Aspergillus flavus</i> and aflatoxins contamination.Kunzhi JiaLijuan YanYipu JiaShuting XuZhaoqi YanShihua WangMDPI AGarticle<i>Aspergillus flavus</i>AflNaflatoxinconidiationMedicineRENToxins, Vol 13, Iss 831, p 831 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Aspergillus flavus</i> AflN aflatoxin conidiation Medicine R
spellingShingle	<i>Aspergillus flavus</i> AflN aflatoxin conidiation Medicine R Kunzhi Jia Lijuan Yan Yipu Jia Shuting Xu Zhaoqi Yan Shihua Wang <i>aflN</i> Is Involved in the Biosynthesis of Aflatoxin and Conidiation in <i>Aspergillus flavus</i>
description	<i>Aspergillus flavus</i> poses a threat to society economy and public health due to aflatoxin production. <i>aflN</i> is a gene located in the aflatoxin gene cluster, but the function of AflN is undefined in <i>Aspergillus flavus</i>. In this study, <i>aflN</i> is knocked out and overexpressed to study the function of AflN. The results indicated that the loss of AflN leads to the defect of aflatoxin biosynthesis. AflN is also found to play a role in conidiation but not hyphal growth and sclerotia development. Moreover, AlfN is related to the response to environmental oxidative stress and intracellular levels of reactive oxygen species. At last, AflN is involved in the pathogenicity of <i>Aspergillus flavus</i> to host. These results suggested that AflN played important roles in aflatoxin biosynthesis, conidiation and reactive oxygen species generation in <i>Aspergillus flavus</i>, which will be helpful for the understanding of <i>aflN</i> function, and will be beneficial to the prevention and control of <i>Aspergillus flavus</i> and aflatoxins contamination.
format	article
author	Kunzhi Jia Lijuan Yan Yipu Jia Shuting Xu Zhaoqi Yan Shihua Wang
author_facet	Kunzhi Jia Lijuan Yan Yipu Jia Shuting Xu Zhaoqi Yan Shihua Wang
author_sort	Kunzhi Jia
title	<i>aflN</i> Is Involved in the Biosynthesis of Aflatoxin and Conidiation in <i>Aspergillus flavus</i>
title_short	<i>aflN</i> Is Involved in the Biosynthesis of Aflatoxin and Conidiation in <i>Aspergillus flavus</i>
title_full	<i>aflN</i> Is Involved in the Biosynthesis of Aflatoxin and Conidiation in <i>Aspergillus flavus</i>
title_fullStr	<i>aflN</i> Is Involved in the Biosynthesis of Aflatoxin and Conidiation in <i>Aspergillus flavus</i>
title_full_unstemmed	<i>aflN</i> Is Involved in the Biosynthesis of Aflatoxin and Conidiation in <i>Aspergillus flavus</i>
title_sort	<i>afln</i> is involved in the biosynthesis of aflatoxin and conidiation in <i>aspergillus flavus</i>
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2e636639075a49c3a9b75b5ed60d5300
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<i>aflN</i> Is Involved in the Biosynthesis of Aflatoxin and Conidiation in <i>Aspergillus flavus</i>

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