Potential Role and Excretion Level of Urinary Transferrin, KIM-1, RBP, MCP-1 and NGAL Markers in Diabetic Nephropathy

Khalid Siddiqui,1 Salini Scaria Joy,1 Teena Puthiyaparampil George,1 Muhammad Mujammami,1– 3 Assim A Alfadda1,3,4 1Strategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia; 2University Diabetes Center, King Saud University Medical City, King S...

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Autores principales:	Siddiqui K, Joy SS, George TP, Mujammami M, Alfadda AA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	diabetic kidney disease urinary markers albuminuria transferrin kidney injury molecule-1 retinol binding protein monocyte chemoattractant protein-1 neutrophil gelatinase-associated lipocalin Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/2e638a62ea7b45b1a0a6f23bb4bbce56
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spelling	oai:doaj.org-article:2e638a62ea7b45b1a0a6f23bb4bbce562021-12-02T11:56:36ZPotential Role and Excretion Level of Urinary Transferrin, KIM-1, RBP, MCP-1 and NGAL Markers in Diabetic Nephropathy1178-7007https://doaj.org/article/2e638a62ea7b45b1a0a6f23bb4bbce562020-12-01T00:00:00Zhttps://www.dovepress.com/potential-role-and-excretion-level-of-urinary-transferrin-kim-1-rbp-mc-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Khalid Siddiqui,1 Salini Scaria Joy,1 Teena Puthiyaparampil George,1 Muhammad Mujammami,1– 3 Assim A Alfadda1,3,4 1Strategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia; 2University Diabetes Center, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia; 3Department of Medicine, College of Medicine, and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia; 4Obesity Research Center, College of Medicine, King Saud University, Riyadh, Saudi ArabiaCorrespondence: Khalid SiddiquiStrategic Center for Diabetes Research, College of Medicine, King Saud University, P.O. Box 245, Riyadh 11411, Kingdom of Saudi ArabiaTel +966 114724179 ext.1340Email ksiddiqui@ksu.edu.saBackground: Analyzing urinary biomarkers may provide better insight into pathophysiological mechanisms of diabetic kidney diseases. The study aimed to analyze the pattern of selected excreted urinary biomarkers and its correlation with albuminuria and estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes.Methods: A total of 185 patients with type 2 diabetes were categorized according to KDIGO guideline based on albuminuria and eGFR. The urinary markers (transferrin, KIM-1, RBP, MCP-1 and NGAL) were measured by ELISA.Results: The urinary markers were associated with eGFR (total protein/Cr, p=0.001; RBP/Cr, p=0.007; MCP-1/Cr, p=0.023; NGAL/Cr, p=0.011) and albuminuria (total protein/Cr, p< 0.001; transferrin, p< 0.001; RBP/Cr, p< 0.001; MCP-1/Cr, p< 0.001; NGAL/Cr, p=0.002).Conclusion: The urinary marker levels (total protein, RBP, MCP-1, and NGAL) are elevated with severity of kidney damage and expressed more in progressive renal impairment.Keywords: diabetic kidney disease, urinary markers, albuminuria, transferrin, kidney injury molecule-1, retinol-binding protein, monocyte chemoattractant protein-1, neutrophil gelatinase-associated lipocalinSiddiqui KJoy SSGeorge TPMujammami MAlfadda AADove Medical Pressarticlediabetic kidney diseaseurinary markersalbuminuriatransferrinkidney injury molecule-1retinol binding proteinmonocyte chemoattractant protein-1neutrophil gelatinase-associated lipocalinSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 5103-5111 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetic kidney disease urinary markers albuminuria transferrin kidney injury molecule-1 retinol binding protein monocyte chemoattractant protein-1 neutrophil gelatinase-associated lipocalin Specialties of internal medicine RC581-951
spellingShingle	diabetic kidney disease urinary markers albuminuria transferrin kidney injury molecule-1 retinol binding protein monocyte chemoattractant protein-1 neutrophil gelatinase-associated lipocalin Specialties of internal medicine RC581-951 Siddiqui K Joy SS George TP Mujammami M Alfadda AA Potential Role and Excretion Level of Urinary Transferrin, KIM-1, RBP, MCP-1 and NGAL Markers in Diabetic Nephropathy
description	Khalid Siddiqui,1 Salini Scaria Joy,1 Teena Puthiyaparampil George,1 Muhammad Mujammami,1– 3 Assim A Alfadda1,3,4 1Strategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia; 2University Diabetes Center, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia; 3Department of Medicine, College of Medicine, and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia; 4Obesity Research Center, College of Medicine, King Saud University, Riyadh, Saudi ArabiaCorrespondence: Khalid SiddiquiStrategic Center for Diabetes Research, College of Medicine, King Saud University, P.O. Box 245, Riyadh 11411, Kingdom of Saudi ArabiaTel +966 114724179 ext.1340Email ksiddiqui@ksu.edu.saBackground: Analyzing urinary biomarkers may provide better insight into pathophysiological mechanisms of diabetic kidney diseases. The study aimed to analyze the pattern of selected excreted urinary biomarkers and its correlation with albuminuria and estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes.Methods: A total of 185 patients with type 2 diabetes were categorized according to KDIGO guideline based on albuminuria and eGFR. The urinary markers (transferrin, KIM-1, RBP, MCP-1 and NGAL) were measured by ELISA.Results: The urinary markers were associated with eGFR (total protein/Cr, p=0.001; RBP/Cr, p=0.007; MCP-1/Cr, p=0.023; NGAL/Cr, p=0.011) and albuminuria (total protein/Cr, p< 0.001; transferrin, p< 0.001; RBP/Cr, p< 0.001; MCP-1/Cr, p< 0.001; NGAL/Cr, p=0.002).Conclusion: The urinary marker levels (total protein, RBP, MCP-1, and NGAL) are elevated with severity of kidney damage and expressed more in progressive renal impairment.Keywords: diabetic kidney disease, urinary markers, albuminuria, transferrin, kidney injury molecule-1, retinol-binding protein, monocyte chemoattractant protein-1, neutrophil gelatinase-associated lipocalin
format	article
author	Siddiqui K Joy SS George TP Mujammami M Alfadda AA
author_facet	Siddiqui K Joy SS George TP Mujammami M Alfadda AA
author_sort	Siddiqui K
title	Potential Role and Excretion Level of Urinary Transferrin, KIM-1, RBP, MCP-1 and NGAL Markers in Diabetic Nephropathy
title_short	Potential Role and Excretion Level of Urinary Transferrin, KIM-1, RBP, MCP-1 and NGAL Markers in Diabetic Nephropathy
title_full	Potential Role and Excretion Level of Urinary Transferrin, KIM-1, RBP, MCP-1 and NGAL Markers in Diabetic Nephropathy
title_fullStr	Potential Role and Excretion Level of Urinary Transferrin, KIM-1, RBP, MCP-1 and NGAL Markers in Diabetic Nephropathy
title_full_unstemmed	Potential Role and Excretion Level of Urinary Transferrin, KIM-1, RBP, MCP-1 and NGAL Markers in Diabetic Nephropathy
title_sort	potential role and excretion level of urinary transferrin, kim-1, rbp, mcp-1 and ngal markers in diabetic nephropathy
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/2e638a62ea7b45b1a0a6f23bb4bbce56
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Potential Role and Excretion Level of Urinary Transferrin, KIM-1, RBP, MCP-1 and NGAL Markers in Diabetic Nephropathy

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