Chiral phosphoric acid-catalyzed stereodivergent synthesis of trisubstituted allenes and computational mechanistic studies

Despite of the high demand of chiral allenes, their asymmetric synthesis remains a challenge for organic chemists. Here, the authors report a stereodivergent synthesis of trisubstituted allenes via asymmetric additions of oxazolones to activated 1,3-enynes enabled by modification of chiral phosphori...

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Autores principales:	Jiawen Wang, Sujuan Zheng, Subramani Rajkumar, Jinglei Xie, Na Yu, Qian Peng, Xiaoyu Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2e667e3425704a8188b626a984d0d05f
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spelling	oai:doaj.org-article:2e667e3425704a8188b626a984d0d05f2021-12-02T14:42:46ZChiral phosphoric acid-catalyzed stereodivergent synthesis of trisubstituted allenes and computational mechanistic studies10.1038/s41467-020-19294-82041-1723https://doaj.org/article/2e667e3425704a8188b626a984d0d05f2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19294-8https://doaj.org/toc/2041-1723Despite of the high demand of chiral allenes, their asymmetric synthesis remains a challenge for organic chemists. Here, the authors report a stereodivergent synthesis of trisubstituted allenes via asymmetric additions of oxazolones to activated 1,3-enynes enabled by modification of chiral phosphoric acid catalysts.Jiawen WangSujuan ZhengSubramani RajkumarJinglei XieNa YuQian PengXiaoyu YangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jiawen Wang Sujuan Zheng Subramani Rajkumar Jinglei Xie Na Yu Qian Peng Xiaoyu Yang Chiral phosphoric acid-catalyzed stereodivergent synthesis of trisubstituted allenes and computational mechanistic studies
description	Despite of the high demand of chiral allenes, their asymmetric synthesis remains a challenge for organic chemists. Here, the authors report a stereodivergent synthesis of trisubstituted allenes via asymmetric additions of oxazolones to activated 1,3-enynes enabled by modification of chiral phosphoric acid catalysts.
format	article
author	Jiawen Wang Sujuan Zheng Subramani Rajkumar Jinglei Xie Na Yu Qian Peng Xiaoyu Yang
author_facet	Jiawen Wang Sujuan Zheng Subramani Rajkumar Jinglei Xie Na Yu Qian Peng Xiaoyu Yang
author_sort	Jiawen Wang
title	Chiral phosphoric acid-catalyzed stereodivergent synthesis of trisubstituted allenes and computational mechanistic studies
title_short	Chiral phosphoric acid-catalyzed stereodivergent synthesis of trisubstituted allenes and computational mechanistic studies
title_full	Chiral phosphoric acid-catalyzed stereodivergent synthesis of trisubstituted allenes and computational mechanistic studies
title_fullStr	Chiral phosphoric acid-catalyzed stereodivergent synthesis of trisubstituted allenes and computational mechanistic studies
title_full_unstemmed	Chiral phosphoric acid-catalyzed stereodivergent synthesis of trisubstituted allenes and computational mechanistic studies
title_sort	chiral phosphoric acid-catalyzed stereodivergent synthesis of trisubstituted allenes and computational mechanistic studies
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2e667e3425704a8188b626a984d0d05f
work_keys_str_mv	AT jiawenwang chiralphosphoricacidcatalyzedstereodivergentsynthesisoftrisubstitutedallenesandcomputationalmechanisticstudies AT sujuanzheng chiralphosphoricacidcatalyzedstereodivergentsynthesisoftrisubstitutedallenesandcomputationalmechanisticstudies AT subramanirajkumar chiralphosphoricacidcatalyzedstereodivergentsynthesisoftrisubstitutedallenesandcomputationalmechanisticstudies AT jingleixie chiralphosphoricacidcatalyzedstereodivergentsynthesisoftrisubstitutedallenesandcomputationalmechanisticstudies AT nayu chiralphosphoricacidcatalyzedstereodivergentsynthesisoftrisubstitutedallenesandcomputationalmechanisticstudies AT qianpeng chiralphosphoricacidcatalyzedstereodivergentsynthesisoftrisubstitutedallenesandcomputationalmechanisticstudies AT xiaoyuyang chiralphosphoricacidcatalyzedstereodivergentsynthesisoftrisubstitutedallenesandcomputationalmechanisticstudies
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Chiral phosphoric acid-catalyzed stereodivergent synthesis of trisubstituted allenes and computational mechanistic studies

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