Electrostatic flocking of salt-treated microfibers and nanofiber yarns for regenerative engineering

Electrostatic flocking is a textile technology that employs a Coulombic driving force to launch short fibers from a charging source towards an adhesive-covered substrate, resulting in a dense array of aligned fibers perpendicular to the substrate. However, electrostatic flocking of insulative polyme...

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Autores principales:	Alec McCarthy, Kossi Loic M. Avegnon, Phil A. Holubeck, Demi Brown, Anik Karan, Navatha Shree Sharma, Johnson V. John, Shelbie Weihs, Jazmin Ley, Jingwei Xie
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Electrostatic flocking Microfibers Nanofiber yarns Wound healing Artificial vertebral disc Medicine (General) R5-920 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2e6d72bc03224b5d9f6e2dae4d642500
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spelling	oai:doaj.org-article:2e6d72bc03224b5d9f6e2dae4d6425002021-12-02T05:03:33ZElectrostatic flocking of salt-treated microfibers and nanofiber yarns for regenerative engineering2590-006410.1016/j.mtbio.2021.100166https://doaj.org/article/2e6d72bc03224b5d9f6e2dae4d6425002021-09-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2590006421000740https://doaj.org/toc/2590-0064Electrostatic flocking is a textile technology that employs a Coulombic driving force to launch short fibers from a charging source towards an adhesive-covered substrate, resulting in a dense array of aligned fibers perpendicular to the substrate. However, electrostatic flocking of insulative polymeric fibers remains a challenge due to their insufficient charge accumulation. We report a facile method to flock electrostatically insulative poly(ε-caprolactone) (PCL) microfibers (MFs) and electrospun PCL nanofiber yarns (NFYs) by incorporating NaCl during pre-flock processing. Both MF and NFY were evaluated for flock functionality, mechanical properties, and biological responses. To demonstrate this platform's diverse applications, standalone flocked NFY and MF scaffolds were synthesized and evaluated as scaffold for cell growth. Employing the same methodology, scaffolds made from poly(glycolide-co-l-lactide) (PGLA) (90:10) MFs were evaluated for their wound healing capacity in a diabetic mouse model. Further, a flock-reinforced polydimethylsiloxane (PDMS) disc was fabricated to create an anisotropic artificial vertebral disc (AVD) replacement potentially used as a treatment for lumbar degenerative disc disease. Overall, a salt-based flocking method is described with MFs and NFYs, with wound healing and AVD repair applications presented.Alec McCarthyKossi Loic M. AvegnonPhil A. HolubeckDemi BrownAnik KaranNavatha Shree SharmaJohnson V. JohnShelbie WeihsJazmin LeyJingwei XieElsevierarticleElectrostatic flockingMicrofibersNanofiber yarnsWound healingArtificial vertebral discMedicine (General)R5-920Biology (General)QH301-705.5ENMaterials Today Bio, Vol 12, Iss , Pp 100166- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Electrostatic flocking Microfibers Nanofiber yarns Wound healing Artificial vertebral disc Medicine (General) R5-920 Biology (General) QH301-705.5
spellingShingle	Electrostatic flocking Microfibers Nanofiber yarns Wound healing Artificial vertebral disc Medicine (General) R5-920 Biology (General) QH301-705.5 Alec McCarthy Kossi Loic M. Avegnon Phil A. Holubeck Demi Brown Anik Karan Navatha Shree Sharma Johnson V. John Shelbie Weihs Jazmin Ley Jingwei Xie Electrostatic flocking of salt-treated microfibers and nanofiber yarns for regenerative engineering
description	Electrostatic flocking is a textile technology that employs a Coulombic driving force to launch short fibers from a charging source towards an adhesive-covered substrate, resulting in a dense array of aligned fibers perpendicular to the substrate. However, electrostatic flocking of insulative polymeric fibers remains a challenge due to their insufficient charge accumulation. We report a facile method to flock electrostatically insulative poly(ε-caprolactone) (PCL) microfibers (MFs) and electrospun PCL nanofiber yarns (NFYs) by incorporating NaCl during pre-flock processing. Both MF and NFY were evaluated for flock functionality, mechanical properties, and biological responses. To demonstrate this platform's diverse applications, standalone flocked NFY and MF scaffolds were synthesized and evaluated as scaffold for cell growth. Employing the same methodology, scaffolds made from poly(glycolide-co-l-lactide) (PGLA) (90:10) MFs were evaluated for their wound healing capacity in a diabetic mouse model. Further, a flock-reinforced polydimethylsiloxane (PDMS) disc was fabricated to create an anisotropic artificial vertebral disc (AVD) replacement potentially used as a treatment for lumbar degenerative disc disease. Overall, a salt-based flocking method is described with MFs and NFYs, with wound healing and AVD repair applications presented.
format	article
author	Alec McCarthy Kossi Loic M. Avegnon Phil A. Holubeck Demi Brown Anik Karan Navatha Shree Sharma Johnson V. John Shelbie Weihs Jazmin Ley Jingwei Xie
author_facet	Alec McCarthy Kossi Loic M. Avegnon Phil A. Holubeck Demi Brown Anik Karan Navatha Shree Sharma Johnson V. John Shelbie Weihs Jazmin Ley Jingwei Xie
author_sort	Alec McCarthy
title	Electrostatic flocking of salt-treated microfibers and nanofiber yarns for regenerative engineering
title_short	Electrostatic flocking of salt-treated microfibers and nanofiber yarns for regenerative engineering
title_full	Electrostatic flocking of salt-treated microfibers and nanofiber yarns for regenerative engineering
title_fullStr	Electrostatic flocking of salt-treated microfibers and nanofiber yarns for regenerative engineering
title_full_unstemmed	Electrostatic flocking of salt-treated microfibers and nanofiber yarns for regenerative engineering
title_sort	electrostatic flocking of salt-treated microfibers and nanofiber yarns for regenerative engineering
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/2e6d72bc03224b5d9f6e2dae4d642500
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Electrostatic flocking of salt-treated microfibers and nanofiber yarns for regenerative engineering

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