Low expression of miR-29a is associated with aggressive biology and worse survival in gastric cancer

Abstract Advanced gastric cancer (GC) is one of the most lethal cancer types, thus a better understanding of its biology in patients is urgently needed. MicroRNA (miR)-29a is a known tumor suppressive miR that is related to metastasis, but its clinical relevance in GC remains ambiguous. Here, using...

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Autores principales:	Yoshihisa Tokumaru, Masanori Oshi, Michelle R. Huyser, Li Yan, Masahiro Fukada, Nobuhisa Matsuhashi, Manabu Futamura, Yukihiro Akao, Kazuhiro Yoshida, Kazuaki Takabe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2e78e900ae834d0e990a3b64daadad1c
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spelling	oai:doaj.org-article:2e78e900ae834d0e990a3b64daadad1c2021-12-02T15:40:00ZLow expression of miR-29a is associated with aggressive biology and worse survival in gastric cancer10.1038/s41598-021-93681-z2045-2322https://doaj.org/article/2e78e900ae834d0e990a3b64daadad1c2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93681-zhttps://doaj.org/toc/2045-2322Abstract Advanced gastric cancer (GC) is one of the most lethal cancer types, thus a better understanding of its biology in patients is urgently needed. MicroRNA (miR)-29a is a known tumor suppressive miR that is related to metastasis, but its clinical relevance in GC remains ambiguous. Here, using a large GC patient cohort we hypothesized that low expression of miR-29a in GC is associated with aggressive cancer biology and worse survival. We demonstrated that low miR-29a GC enriched cell proliferation, apoptosis, metastasis, and angiogenesis related gene sets, as well as the higher expression of related genes. Low miR-29a GC was associated with less anti-cancer immune cell infiltration as well as immune related scoring. Low miR-29a GC demonstrated a worse overall survival (OS) as well as disease specific survival (DSS) compared with high expressing miR-29a GC. Notably, low miR-29a expression was the only factor, other than residual tumor status, to be an independent prognostic biomarker of worse OS and DSS. In conclusion, low miR-29a GC was associated with aggressive cancer biology and worse OS as well as DSS. Additionally, low expression of miR-29a was an independent prognostic biomarker of OS and DSS in gastric cancer patients.Yoshihisa TokumaruMasanori OshiMichelle R. HuyserLi YanMasahiro FukadaNobuhisa MatsuhashiManabu FutamuraYukihiro AkaoKazuhiro YoshidaKazuaki TakabeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoshihisa Tokumaru Masanori Oshi Michelle R. Huyser Li Yan Masahiro Fukada Nobuhisa Matsuhashi Manabu Futamura Yukihiro Akao Kazuhiro Yoshida Kazuaki Takabe Low expression of miR-29a is associated with aggressive biology and worse survival in gastric cancer
description	Abstract Advanced gastric cancer (GC) is one of the most lethal cancer types, thus a better understanding of its biology in patients is urgently needed. MicroRNA (miR)-29a is a known tumor suppressive miR that is related to metastasis, but its clinical relevance in GC remains ambiguous. Here, using a large GC patient cohort we hypothesized that low expression of miR-29a in GC is associated with aggressive cancer biology and worse survival. We demonstrated that low miR-29a GC enriched cell proliferation, apoptosis, metastasis, and angiogenesis related gene sets, as well as the higher expression of related genes. Low miR-29a GC was associated with less anti-cancer immune cell infiltration as well as immune related scoring. Low miR-29a GC demonstrated a worse overall survival (OS) as well as disease specific survival (DSS) compared with high expressing miR-29a GC. Notably, low miR-29a expression was the only factor, other than residual tumor status, to be an independent prognostic biomarker of worse OS and DSS. In conclusion, low miR-29a GC was associated with aggressive cancer biology and worse OS as well as DSS. Additionally, low expression of miR-29a was an independent prognostic biomarker of OS and DSS in gastric cancer patients.
format	article
author	Yoshihisa Tokumaru Masanori Oshi Michelle R. Huyser Li Yan Masahiro Fukada Nobuhisa Matsuhashi Manabu Futamura Yukihiro Akao Kazuhiro Yoshida Kazuaki Takabe
author_facet	Yoshihisa Tokumaru Masanori Oshi Michelle R. Huyser Li Yan Masahiro Fukada Nobuhisa Matsuhashi Manabu Futamura Yukihiro Akao Kazuhiro Yoshida Kazuaki Takabe
author_sort	Yoshihisa Tokumaru
title	Low expression of miR-29a is associated with aggressive biology and worse survival in gastric cancer
title_short	Low expression of miR-29a is associated with aggressive biology and worse survival in gastric cancer
title_full	Low expression of miR-29a is associated with aggressive biology and worse survival in gastric cancer
title_fullStr	Low expression of miR-29a is associated with aggressive biology and worse survival in gastric cancer
title_full_unstemmed	Low expression of miR-29a is associated with aggressive biology and worse survival in gastric cancer
title_sort	low expression of mir-29a is associated with aggressive biology and worse survival in gastric cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2e78e900ae834d0e990a3b64daadad1c
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Low expression of miR-29a is associated with aggressive biology and worse survival in gastric cancer

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