The Association between ERBB4 Gene Polymorphism (SNP: Rs1972820g>A) and the Risk of Breast Cancer

BACKGROUND AND OBJECTIVE: Breast cancer is the most common cancer in women and the leading cause of cancer death in women worldwide. The ERBB4 gene, a member of the tyrosine kinase family, has been identified as both a tumor suppressor and an oncogene in breast cancer. In this study, the association...

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Autores principales:	M Zorriye Mahmoud, S Ghaffarian, M Valipour, N Pouladi, V Montazeri
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2021
Materias:	breast cancer single nucleotide polymorphism association evaluation erbb4 gene. Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2e7b1c9b613542db9a7797defc9e0f82
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spelling	oai:doaj.org-article:2e7b1c9b613542db9a7797defc9e0f822021-11-29T07:40:50ZThe Association between ERBB4 Gene Polymorphism (SNP: Rs1972820g>A) and the Risk of Breast Cancer1561-41072251-7170https://doaj.org/article/2e7b1c9b613542db9a7797defc9e0f822021-03-01T00:00:00Zhttp://jbums.org/article-1-9922-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Breast cancer is the most common cancer in women and the leading cause of cancer death in women worldwide. The ERBB4 gene, a member of the tyrosine kinase family, has been identified as both a tumor suppressor and an oncogene in breast cancer. In this study, the association between rs1972820G>A polymorphism of ERBB4 gene and the risk of breast cancer in northwestern Iran was investigated. METHODS: This case-control study was performed on 89 women with breast cancer and 98 healthy women with no family history of cancer. Clinical characteristics of patients included age (less than, greater than or equal to 49 years and unknown), involved side (right, left, both and unknown), type of tumor (ILC, IDC, other types and unknown), tumor grade (I, II or III), tumor size (T1, T2, T3 and unknown) and lymph node involvement (N0, N1, N2, N3 and unknown). Single nucleotide polymorphisms were examined by TETRA-ARMS-PCR technique. FINDINGS: The genotypic distribution of sick and healthy individuals was 66% and 56% for AA genotype, 9% and 6% for GG genotype and 25% and 38% for AG genotype, respectively. The frequency of Allele A was 147 and 140 and the frequency of G Allele was 49 and 38 in patients and controls, respectively (p>0.05). CONCLUSION: The findings of this study showed that there is no significant relationship between genotypic and allelic distribution of rs1972820 polymorphism of ERBB4 gene with increased risk of breast cancer and clinical features of patients in northwestern Iran.M Zorriye MahmoudS GhaffarianM ValipourN PouladiV MontazeriBabol University of Medical Sciencesarticlebreast cancersingle nucleotide polymorphismassociation evaluationerbb4 gene.MedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 23, Iss 1, Pp 386-392 (2021)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	breast cancer single nucleotide polymorphism association evaluation erbb4 gene. Medicine R Medicine (General) R5-920
spellingShingle	breast cancer single nucleotide polymorphism association evaluation erbb4 gene. Medicine R Medicine (General) R5-920 M Zorriye Mahmoud S Ghaffarian M Valipour N Pouladi V Montazeri The Association between ERBB4 Gene Polymorphism (SNP: Rs1972820g>A) and the Risk of Breast Cancer
description	BACKGROUND AND OBJECTIVE: Breast cancer is the most common cancer in women and the leading cause of cancer death in women worldwide. The ERBB4 gene, a member of the tyrosine kinase family, has been identified as both a tumor suppressor and an oncogene in breast cancer. In this study, the association between rs1972820G>A polymorphism of ERBB4 gene and the risk of breast cancer in northwestern Iran was investigated. METHODS: This case-control study was performed on 89 women with breast cancer and 98 healthy women with no family history of cancer. Clinical characteristics of patients included age (less than, greater than or equal to 49 years and unknown), involved side (right, left, both and unknown), type of tumor (ILC, IDC, other types and unknown), tumor grade (I, II or III), tumor size (T1, T2, T3 and unknown) and lymph node involvement (N0, N1, N2, N3 and unknown). Single nucleotide polymorphisms were examined by TETRA-ARMS-PCR technique. FINDINGS: The genotypic distribution of sick and healthy individuals was 66% and 56% for AA genotype, 9% and 6% for GG genotype and 25% and 38% for AG genotype, respectively. The frequency of Allele A was 147 and 140 and the frequency of G Allele was 49 and 38 in patients and controls, respectively (p>0.05). CONCLUSION: The findings of this study showed that there is no significant relationship between genotypic and allelic distribution of rs1972820 polymorphism of ERBB4 gene with increased risk of breast cancer and clinical features of patients in northwestern Iran.
format	article
author	M Zorriye Mahmoud S Ghaffarian M Valipour N Pouladi V Montazeri
author_facet	M Zorriye Mahmoud S Ghaffarian M Valipour N Pouladi V Montazeri
author_sort	M Zorriye Mahmoud
title	The Association between ERBB4 Gene Polymorphism (SNP: Rs1972820g>A) and the Risk of Breast Cancer
title_short	The Association between ERBB4 Gene Polymorphism (SNP: Rs1972820g>A) and the Risk of Breast Cancer
title_full	The Association between ERBB4 Gene Polymorphism (SNP: Rs1972820g>A) and the Risk of Breast Cancer
title_fullStr	The Association between ERBB4 Gene Polymorphism (SNP: Rs1972820g>A) and the Risk of Breast Cancer
title_full_unstemmed	The Association between ERBB4 Gene Polymorphism (SNP: Rs1972820g>A) and the Risk of Breast Cancer
title_sort	association between erbb4 gene polymorphism (snp: rs1972820g>a) and the risk of breast cancer
publisher	Babol University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/2e7b1c9b613542db9a7797defc9e0f82
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The Association between ERBB4 Gene Polymorphism (SNP: Rs1972820g>A) and the Risk of Breast Cancer

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