Gli1 identifies osteogenic progenitors for bone formation and fracture repair

Skeletal progenitors in postnatal mice are highly heterogeneous. Using lineage tracing and RNA-seq the authors show that Gli1+ cells give rise to all osteoblasts in mice, including those required for healing of bone fractures.

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Detalles Bibliográficos
Autores principales: Yu Shi, Guangxu He, Wen-Chih Lee, Jennifer A. McKenzie, Matthew J. Silva, Fanxin Long
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/2e832ba4b2fa485480ba446d775d50b6
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Descripción
Sumario:Skeletal progenitors in postnatal mice are highly heterogeneous. Using lineage tracing and RNA-seq the authors show that Gli1+ cells give rise to all osteoblasts in mice, including those required for healing of bone fractures.