Gli1 identifies osteogenic progenitors for bone formation and fracture repair

Gli1 identifies osteogenic progenitors for bone formation and fracture repair

Skeletal progenitors in postnatal mice are highly heterogeneous. Using lineage tracing and RNA-seq the authors show that Gli1+ cells give rise to all osteoblasts in mice, including those required for healing of bone fractures.

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Autores principales: Yu Shi, Guangxu He, Wen-Chih Lee, Jennifer A. McKenzie, Matthew J. Silva, Fanxin Long
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/2e832ba4b2fa485480ba446d775d50b6
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spelling oai:doaj.org-article:2e832ba4b2fa485480ba446d775d50b62021-12-02T17:06:00ZGli1 identifies osteogenic progenitors for bone formation and fracture repair10.1038/s41467-017-02171-22041-1723https://doaj.org/article/2e832ba4b2fa485480ba446d775d50b62017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02171-2https://doaj.org/toc/2041-1723Skeletal progenitors in postnatal mice are highly heterogeneous. Using lineage tracing and RNA-seq the authors show that Gli1+ cells give rise to all osteoblasts in mice, including those required for healing of bone fractures.Yu ShiGuangxu HeWen-Chih LeeJennifer A. McKenzieMatthew J. SilvaFanxin LongNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yu Shi
Guangxu He
Wen-Chih Lee
Jennifer A. McKenzie
Matthew J. Silva
Fanxin Long
Gli1 identifies osteogenic progenitors for bone formation and fracture repair
description Skeletal progenitors in postnatal mice are highly heterogeneous. Using lineage tracing and RNA-seq the authors show that Gli1+ cells give rise to all osteoblasts in mice, including those required for healing of bone fractures.
format article
author Yu Shi
Guangxu He
Wen-Chih Lee
Jennifer A. McKenzie
Matthew J. Silva
Fanxin Long
author_facet Yu Shi
Guangxu He
Wen-Chih Lee
Jennifer A. McKenzie
Matthew J. Silva
Fanxin Long
author_sort Yu Shi
title Gli1 identifies osteogenic progenitors for bone formation and fracture repair
title_short Gli1 identifies osteogenic progenitors for bone formation and fracture repair
title_full Gli1 identifies osteogenic progenitors for bone formation and fracture repair
title_fullStr Gli1 identifies osteogenic progenitors for bone formation and fracture repair
title_full_unstemmed Gli1 identifies osteogenic progenitors for bone formation and fracture repair
title_sort gli1 identifies osteogenic progenitors for bone formation and fracture repair
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/2e832ba4b2fa485480ba446d775d50b6
work_keys_str_mv AT yushi gli1identifiesosteogenicprogenitorsforboneformationandfracturerepair
AT guangxuhe gli1identifiesosteogenicprogenitorsforboneformationandfracturerepair
AT wenchihlee gli1identifiesosteogenicprogenitorsforboneformationandfracturerepair
AT jenniferamckenzie gli1identifiesosteogenicprogenitorsforboneformationandfracturerepair
AT matthewjsilva gli1identifiesosteogenicprogenitorsforboneformationandfracturerepair
AT fanxinlong gli1identifiesosteogenicprogenitorsforboneformationandfracturerepair
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