Increased concentration of hyaluronan in tears after soaking contact lenses in Biotrue multipurpose solution

Catherine A Scheuer, Marjorie J Rah, William T Reindel Vision Care, Bausch & Lomb Incorporated, Rochester, NY, USA Purpose: This study was conducted to determine 1) the concentration of hyaluronan (HA) in the tear films of contact lens (CL) wearers versus non-CL wearers and 2) whether HA s...

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Autores principales:	Scheuer CA, Rah MJ, Reindel WT
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	contact lens dry eye hyaluronan MPS Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/2e83a71eae114de9b2b73ba743ec13c7
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spelling	oai:doaj.org-article:2e83a71eae114de9b2b73ba743ec13c72021-12-02T00:02:42ZIncreased concentration of hyaluronan in tears after soaking contact lenses in Biotrue multipurpose solution1177-5483https://doaj.org/article/2e83a71eae114de9b2b73ba743ec13c72016-10-01T00:00:00Zhttps://www.dovepress.com/increased-concentration-of-hyaluronan-in-tears-after-soaking-contact-l-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Catherine A Scheuer, Marjorie J Rah, William T Reindel Vision Care, Bausch & Lomb Incorporated, Rochester, NY, USA Purpose: This study was conducted to determine 1) the concentration of hyaluronan (HA) in the tear films of contact lens (CL) wearers versus non-CL wearers and 2) whether HA sorbed from Biotrue, an HA-containing multipurpose solution (MPS), onto senofilcon A lenses affects the concentration of HA in tears after 2 hours of wear.Patients and methods: Tears of habitual CL wearers and non-CL wearers were collected on Schirmer strips at baseline and after 2 hours of wear of senofilcon A CLs that had first been either rinsed with Sensitive Eyes Saline or soaked in Biotrue MPS for 14 hours. HA concentrations were measured by enzyme-linked immunosorbent assay (ELISA) and adjusted for sample volumes.Results: No difference in baseline concentrations of HA in tears was found between CL wearers and non-CL wearers (P=0.07), nor between males and females (P=0.06). However, age was significantly negatively associated with HA concentration (P<0.01), and mostly, CL wear contributed to a significant association (P<0.01). Among saline-rinsed CL wearers, no change in HA concentration in tears was observed after 2 hours of wear (P=0.38). By contrast, a significant increase in HA concentration was observed in the tears from eyes that had worn CLs soaked in Biotrue MPS when compared to baseline (P=0.01) or to saline-rinsed control (P=0.03).Conclusion: 1) In this study population, no difference in baseline concentration of HA was observed between CL wearers and non-CL wearers, and 2) after 2 hours of wear of senofilcon A lenses that were soaked in Biotrue MPS, HA concentrations in the tear films of CL wearers increased. Keywords: contact lens, dry eye, hyaluronan, MPSScheuer CARah MJReindel WTDove Medical Pressarticlecontact lensdry eyehyaluronanMPSOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 10, Pp 1945-1952 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	contact lens dry eye hyaluronan MPS Ophthalmology RE1-994
spellingShingle	contact lens dry eye hyaluronan MPS Ophthalmology RE1-994 Scheuer CA Rah MJ Reindel WT Increased concentration of hyaluronan in tears after soaking contact lenses in Biotrue multipurpose solution
description	Catherine A Scheuer, Marjorie J Rah, William T Reindel Vision Care, Bausch & Lomb Incorporated, Rochester, NY, USA Purpose: This study was conducted to determine 1) the concentration of hyaluronan (HA) in the tear films of contact lens (CL) wearers versus non-CL wearers and 2) whether HA sorbed from Biotrue, an HA-containing multipurpose solution (MPS), onto senofilcon A lenses affects the concentration of HA in tears after 2 hours of wear.Patients and methods: Tears of habitual CL wearers and non-CL wearers were collected on Schirmer strips at baseline and after 2 hours of wear of senofilcon A CLs that had first been either rinsed with Sensitive Eyes Saline or soaked in Biotrue MPS for 14 hours. HA concentrations were measured by enzyme-linked immunosorbent assay (ELISA) and adjusted for sample volumes.Results: No difference in baseline concentrations of HA in tears was found between CL wearers and non-CL wearers (P=0.07), nor between males and females (P=0.06). However, age was significantly negatively associated with HA concentration (P<0.01), and mostly, CL wear contributed to a significant association (P<0.01). Among saline-rinsed CL wearers, no change in HA concentration in tears was observed after 2 hours of wear (P=0.38). By contrast, a significant increase in HA concentration was observed in the tears from eyes that had worn CLs soaked in Biotrue MPS when compared to baseline (P=0.01) or to saline-rinsed control (P=0.03).Conclusion: 1) In this study population, no difference in baseline concentration of HA was observed between CL wearers and non-CL wearers, and 2) after 2 hours of wear of senofilcon A lenses that were soaked in Biotrue MPS, HA concentrations in the tear films of CL wearers increased. Keywords: contact lens, dry eye, hyaluronan, MPS
format	article
author	Scheuer CA Rah MJ Reindel WT
author_facet	Scheuer CA Rah MJ Reindel WT
author_sort	Scheuer CA
title	Increased concentration of hyaluronan in tears after soaking contact lenses in Biotrue multipurpose solution
title_short	Increased concentration of hyaluronan in tears after soaking contact lenses in Biotrue multipurpose solution
title_full	Increased concentration of hyaluronan in tears after soaking contact lenses in Biotrue multipurpose solution
title_fullStr	Increased concentration of hyaluronan in tears after soaking contact lenses in Biotrue multipurpose solution
title_full_unstemmed	Increased concentration of hyaluronan in tears after soaking contact lenses in Biotrue multipurpose solution
title_sort	increased concentration of hyaluronan in tears after soaking contact lenses in biotrue multipurpose solution
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/2e83a71eae114de9b2b73ba743ec13c7
work_keys_str_mv	AT scheuerca increasedconcentrationofhyaluronanintearsaftersoakingcontactlensesinbiotruemultipurposesolution AT rahmj increasedconcentrationofhyaluronanintearsaftersoakingcontactlensesinbiotruemultipurposesolution AT reindelwt increasedconcentrationofhyaluronanintearsaftersoakingcontactlensesinbiotruemultipurposesolution
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Increased concentration of hyaluronan in tears after soaking contact lenses in Biotrue multipurpose solution

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