NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells

Regulatory B cells are important for preventing skin autoimmunity. Here the authors show that NFATc1 suppresses IL-10 transcription in regulatory B cells, and inhibiting NFATc1 decreases immunopathology in a mouse model of imiquimod-induced skin inflammation.

Guardado en:

Detalles Bibliográficos
Autores principales:	Hani Alrefai, Khalid Muhammad, Ronald Rudolf, Duong Anh Thuy Pham, Stefan Klein-Hessling, Amiya K. Patra, Andris Avots, Valesca Bukur, Ugur Sahin, Stefan Tenzer, Matthias Goebeler, Andreas Kerstan, Edgar Serfling
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2e83ccefff114a268fe56783c1489f9c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2e83ccefff114a268fe56783c1489f9c
record_format	dspace
spelling	oai:doaj.org-article:2e83ccefff114a268fe56783c1489f9c2021-12-02T14:38:54ZNFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells10.1038/ncomms117242041-1723https://doaj.org/article/2e83ccefff114a268fe56783c1489f9c2016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11724https://doaj.org/toc/2041-1723Regulatory B cells are important for preventing skin autoimmunity. Here the authors show that NFATc1 suppresses IL-10 transcription in regulatory B cells, and inhibiting NFATc1 decreases immunopathology in a mouse model of imiquimod-induced skin inflammation.Hani AlrefaiKhalid MuhammadRonald RudolfDuong Anh Thuy PhamStefan Klein-HesslingAmiya K. PatraAndris AvotsValesca BukurUgur SahinStefan TenzerMatthias GoebelerAndreas KerstanEdgar SerflingNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hani Alrefai Khalid Muhammad Ronald Rudolf Duong Anh Thuy Pham Stefan Klein-Hessling Amiya K. Patra Andris Avots Valesca Bukur Ugur Sahin Stefan Tenzer Matthias Goebeler Andreas Kerstan Edgar Serfling NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells
description	Regulatory B cells are important for preventing skin autoimmunity. Here the authors show that NFATc1 suppresses IL-10 transcription in regulatory B cells, and inhibiting NFATc1 decreases immunopathology in a mouse model of imiquimod-induced skin inflammation.
format	article
author	Hani Alrefai Khalid Muhammad Ronald Rudolf Duong Anh Thuy Pham Stefan Klein-Hessling Amiya K. Patra Andris Avots Valesca Bukur Ugur Sahin Stefan Tenzer Matthias Goebeler Andreas Kerstan Edgar Serfling
author_facet	Hani Alrefai Khalid Muhammad Ronald Rudolf Duong Anh Thuy Pham Stefan Klein-Hessling Amiya K. Patra Andris Avots Valesca Bukur Ugur Sahin Stefan Tenzer Matthias Goebeler Andreas Kerstan Edgar Serfling
author_sort	Hani Alrefai
title	NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells
title_short	NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells
title_full	NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells
title_fullStr	NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells
title_full_unstemmed	NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells
title_sort	nfatc1 supports imiquimod-induced skin inflammation by suppressing il-10 synthesis in b cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/2e83ccefff114a268fe56783c1489f9c
work_keys_str_mv	AT hanialrefai nfatc1supportsimiquimodinducedskininflammationbysuppressingil10synthesisinbcells AT khalidmuhammad nfatc1supportsimiquimodinducedskininflammationbysuppressingil10synthesisinbcells AT ronaldrudolf nfatc1supportsimiquimodinducedskininflammationbysuppressingil10synthesisinbcells AT duonganhthuypham nfatc1supportsimiquimodinducedskininflammationbysuppressingil10synthesisinbcells AT stefankleinhessling nfatc1supportsimiquimodinducedskininflammationbysuppressingil10synthesisinbcells AT amiyakpatra nfatc1supportsimiquimodinducedskininflammationbysuppressingil10synthesisinbcells AT andrisavots nfatc1supportsimiquimodinducedskininflammationbysuppressingil10synthesisinbcells AT valescabukur nfatc1supportsimiquimodinducedskininflammationbysuppressingil10synthesisinbcells AT ugursahin nfatc1supportsimiquimodinducedskininflammationbysuppressingil10synthesisinbcells AT stefantenzer nfatc1supportsimiquimodinducedskininflammationbysuppressingil10synthesisinbcells AT matthiasgoebeler nfatc1supportsimiquimodinducedskininflammationbysuppressingil10synthesisinbcells AT andreaskerstan nfatc1supportsimiquimodinducedskininflammationbysuppressingil10synthesisinbcells AT edgarserfling nfatc1supportsimiquimodinducedskininflammationbysuppressingil10synthesisinbcells
_version_	1718390822952501248

NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells

Ejemplares similares