NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells

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NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells

Regulatory B cells are important for preventing skin autoimmunity. Here the authors show that NFATc1 suppresses IL-10 transcription in regulatory B cells, and inhibiting NFATc1 decreases immunopathology in a mouse model of imiquimod-induced skin inflammation.

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Détails bibliographiques
Auteurs principaux:	Hani Alrefai, Khalid Muhammad, Ronald Rudolf, Duong Anh Thuy Pham, Stefan Klein-Hessling, Amiya K. Patra, Andris Avots, Valesca Bukur, Ugur Sahin, Stefan Tenzer, Matthias Goebeler, Andreas Kerstan, Edgar Serfling
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2016
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/2e83ccefff114a268fe56783c1489f9c
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

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