Light activates output from evening neurons and inhibits output from morning neurons in the Drosophila circadian clock.

Animal circadian clocks are based on multiple oscillators whose interactions allow the daily control of complex behaviors. The Drosophila brain contains a circadian clock that controls rest-activity rhythms and relies upon different groups of PERIOD (PER)-expressing neurons. Two distinct oscillators...

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Autores principales:	Marie Picot, Paola Cusumano, André Klarsfeld, Ryu Ueda, François Rouyer
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2007
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2e8592cdc4ac4bf8bf9481cd305a4fa8
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spelling	oai:doaj.org-article:2e8592cdc4ac4bf8bf9481cd305a4fa82021-11-25T05:33:34ZLight activates output from evening neurons and inhibits output from morning neurons in the Drosophila circadian clock.1544-91731545-788510.1371/journal.pbio.0050315https://doaj.org/article/2e8592cdc4ac4bf8bf9481cd305a4fa82007-11-01T00:00:00Zhttps://doi.org/10.1371/journal.pbio.0050315https://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Animal circadian clocks are based on multiple oscillators whose interactions allow the daily control of complex behaviors. The Drosophila brain contains a circadian clock that controls rest-activity rhythms and relies upon different groups of PERIOD (PER)-expressing neurons. Two distinct oscillators have been functionally characterized under light-dark cycles. Lateral neurons (LNs) that express the pigment-dispersing factor (PDF) drive morning activity, whereas PDF-negative LNs are required for the evening activity. In constant darkness, several lines of evidence indicate that the LN morning oscillator (LN-MO) drives the activity rhythms, whereas the LN evening oscillator (LN-EO) does not. Since mutants devoid of functional CRYPTOCHROME (CRY), as opposed to wild-type flies, are rhythmic in constant light, we analyzed transgenic flies expressing PER or CRY in the LN-MO or LN-EO. We show that, under constant light conditions and reduced CRY function, the LN evening oscillator drives robust activity rhythms, whereas the LN morning oscillator does not. Remarkably, light acts by inhibiting the LN-MO behavioral output and activating the LN-EO behavioral output. Finally, we show that PDF signaling is not required for robust activity rhythms in constant light as opposed to its requirement in constant darkness, further supporting the minor contribution of the morning cells to the behavior in the presence of light. We therefore propose that day-night cycles alternatively activate behavioral outputs of the Drosophila evening and morning lateral neurons.Marie PicotPaola CusumanoAndré KlarsfeldRyu UedaFrançois RouyerPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 5, Iss 11, p e315 (2007)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Marie Picot Paola Cusumano André Klarsfeld Ryu Ueda François Rouyer Light activates output from evening neurons and inhibits output from morning neurons in the Drosophila circadian clock.
description	Animal circadian clocks are based on multiple oscillators whose interactions allow the daily control of complex behaviors. The Drosophila brain contains a circadian clock that controls rest-activity rhythms and relies upon different groups of PERIOD (PER)-expressing neurons. Two distinct oscillators have been functionally characterized under light-dark cycles. Lateral neurons (LNs) that express the pigment-dispersing factor (PDF) drive morning activity, whereas PDF-negative LNs are required for the evening activity. In constant darkness, several lines of evidence indicate that the LN morning oscillator (LN-MO) drives the activity rhythms, whereas the LN evening oscillator (LN-EO) does not. Since mutants devoid of functional CRYPTOCHROME (CRY), as opposed to wild-type flies, are rhythmic in constant light, we analyzed transgenic flies expressing PER or CRY in the LN-MO or LN-EO. We show that, under constant light conditions and reduced CRY function, the LN evening oscillator drives robust activity rhythms, whereas the LN morning oscillator does not. Remarkably, light acts by inhibiting the LN-MO behavioral output and activating the LN-EO behavioral output. Finally, we show that PDF signaling is not required for robust activity rhythms in constant light as opposed to its requirement in constant darkness, further supporting the minor contribution of the morning cells to the behavior in the presence of light. We therefore propose that day-night cycles alternatively activate behavioral outputs of the Drosophila evening and morning lateral neurons.
format	article
author	Marie Picot Paola Cusumano André Klarsfeld Ryu Ueda François Rouyer
author_facet	Marie Picot Paola Cusumano André Klarsfeld Ryu Ueda François Rouyer
author_sort	Marie Picot
title	Light activates output from evening neurons and inhibits output from morning neurons in the Drosophila circadian clock.
title_short	Light activates output from evening neurons and inhibits output from morning neurons in the Drosophila circadian clock.
title_full	Light activates output from evening neurons and inhibits output from morning neurons in the Drosophila circadian clock.
title_fullStr	Light activates output from evening neurons and inhibits output from morning neurons in the Drosophila circadian clock.
title_full_unstemmed	Light activates output from evening neurons and inhibits output from morning neurons in the Drosophila circadian clock.
title_sort	light activates output from evening neurons and inhibits output from morning neurons in the drosophila circadian clock.
publisher	Public Library of Science (PLoS)
publishDate	2007
url	https://doaj.org/article/2e8592cdc4ac4bf8bf9481cd305a4fa8
work_keys_str_mv	AT mariepicot lightactivatesoutputfromeveningneuronsandinhibitsoutputfrommorningneuronsinthedrosophilacircadianclock AT paolacusumano lightactivatesoutputfromeveningneuronsandinhibitsoutputfrommorningneuronsinthedrosophilacircadianclock AT andreklarsfeld lightactivatesoutputfromeveningneuronsandinhibitsoutputfrommorningneuronsinthedrosophilacircadianclock AT ryuueda lightactivatesoutputfromeveningneuronsandinhibitsoutputfrommorningneuronsinthedrosophilacircadianclock AT francoisrouyer lightactivatesoutputfromeveningneuronsandinhibitsoutputfrommorningneuronsinthedrosophilacircadianclock
_version_	1718414626893332480

Light activates output from evening neurons and inhibits output from morning neurons in the Drosophila circadian clock.

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