Preliminary comparison of neuropsychological performance in patients with non-small-cell lung cancer treated with chemotherapy or targeted therapy

Hsiu-Ling Kang,1,* Vincent Chin-Hung Chen,2,3,* Wei-Lin Hung,4 Han-Pin Hsiao,2 Wei-Han Wang4,5 1Department of Nursing, Chang Gung Memorial Hospital, Chiayi, Taiwan; 2Department of Psychiatry, Chang Gung Medical Foundation, Chiayi Chang Gung Memorial Hospital, Taiwan; 3School of Medicine, Chang Gung...

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Autores principales:	Kang HL, Chen VCH, Hung WL, Hsiao HP, Wang WH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Non-small-cell lung cancer neuropsychological performance psychomotor speed anxiety depression Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/2e85cad7f2bb48628ea71a4d803fd4a5
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spelling	oai:doaj.org-article:2e85cad7f2bb48628ea71a4d803fd4a52021-12-02T04:32:32ZPreliminary comparison of neuropsychological performance in patients with non-small-cell lung cancer treated with chemotherapy or targeted therapy1178-2021https://doaj.org/article/2e85cad7f2bb48628ea71a4d803fd4a52019-03-01T00:00:00Zhttps://www.dovepress.com/preliminary-comparison-of-neuropsychological-performance-in-patients-w-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Hsiu-Ling Kang,1,* Vincent Chin-Hung Chen,2,3,* Wei-Lin Hung,4 Han-Pin Hsiao,2 Wei-Han Wang4,5 1Department of Nursing, Chang Gung Memorial Hospital, Chiayi, Taiwan; 2Department of Psychiatry, Chang Gung Medical Foundation, Chiayi Chang Gung Memorial Hospital, Taiwan; 3School of Medicine, Chang Gung University, Taoyuan, Taiwan; 4Department of Psychology, Chung Shan Medical University, Taichung, Taiwan; 5Room of Clinical Neuropsychology, Department of Neurology, Chung Shan Medical University Hospital, Taichung, Taiwan *These authors contributed equally to this work Purpose: This cross-sectional pilot study aimed to compare the effects of chemotherapy and targeted therapy on neuropsychological performance and psychiatric symptoms in patients with non-small-cell lung cancer (NSCLC). Patients and methods: A total of 113 patients with NSCLC were recruited. According to their type of cancer treatment, the patients were classified into chemotherapy (n=40), targeted therapy (n=33), and untreated control (n=40) groups. All participants completed five objective tests measuring various domains of cognitive function, a subjective cognitive functioning scale (Functional Assessment of Cancer Therapy–Cognitive Function; FACT-cog), and the Hospital Anxiety and Depression Scale (HADS) either within 6 months after diagnosis (for the untreated group) or about 18 months after treatment. Results: Overall, there were no significant intergroup differences in the proportions of patients with abnormal cognitive performance and psychiatric disturbances. Among the untreated NSCLC patients, 35% had impaired performance in at least one cognitive domain, and a comparable finding (30%–35%) was made for the other two treatment groups. The proportion of patients with impaired psychomotor speed was the highest (10%–15%) across various cognitive domains. Moreover, a significant proportion of NSCLC patients (15%–20%) exhibited HADS-defined anxiety and depression disorder. Finally, significant correlations were found between FACT-cog total scores and the HADS Depression subscale across all three groups. Conclusion: This study demonstrated that 1) a substantial proportion of NSCLC patients exhibited cognitive impairments (especially regarding psychomotor speed) and psychiatric disturbances; 2) no significant differences were observed among the three patient groups for any subjective or objective measure of cognitive deficit; and 3) perceived cognitive impairment was significantly associated with depression or anxiety. Prompt treatment of psychiatric disorders to minimize their impact is therefore recommended. Keywords: non-small-cell lung cancer, neuropsychological performance, psychomotor speed, anxiety, depressionKang HLChen VCHHung WLHsiao HPWang WHDove Medical PressarticleNon-small-cell lung cancerneuropsychological performancepsychomotor speedanxietydepressionNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 753-761 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Non-small-cell lung cancer neuropsychological performance psychomotor speed anxiety depression Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Non-small-cell lung cancer neuropsychological performance psychomotor speed anxiety depression Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Kang HL Chen VCH Hung WL Hsiao HP Wang WH Preliminary comparison of neuropsychological performance in patients with non-small-cell lung cancer treated with chemotherapy or targeted therapy
description	Hsiu-Ling Kang,1,* Vincent Chin-Hung Chen,2,3,* Wei-Lin Hung,4 Han-Pin Hsiao,2 Wei-Han Wang4,5 1Department of Nursing, Chang Gung Memorial Hospital, Chiayi, Taiwan; 2Department of Psychiatry, Chang Gung Medical Foundation, Chiayi Chang Gung Memorial Hospital, Taiwan; 3School of Medicine, Chang Gung University, Taoyuan, Taiwan; 4Department of Psychology, Chung Shan Medical University, Taichung, Taiwan; 5Room of Clinical Neuropsychology, Department of Neurology, Chung Shan Medical University Hospital, Taichung, Taiwan *These authors contributed equally to this work Purpose: This cross-sectional pilot study aimed to compare the effects of chemotherapy and targeted therapy on neuropsychological performance and psychiatric symptoms in patients with non-small-cell lung cancer (NSCLC). Patients and methods: A total of 113 patients with NSCLC were recruited. According to their type of cancer treatment, the patients were classified into chemotherapy (n=40), targeted therapy (n=33), and untreated control (n=40) groups. All participants completed five objective tests measuring various domains of cognitive function, a subjective cognitive functioning scale (Functional Assessment of Cancer Therapy–Cognitive Function; FACT-cog), and the Hospital Anxiety and Depression Scale (HADS) either within 6 months after diagnosis (for the untreated group) or about 18 months after treatment. Results: Overall, there were no significant intergroup differences in the proportions of patients with abnormal cognitive performance and psychiatric disturbances. Among the untreated NSCLC patients, 35% had impaired performance in at least one cognitive domain, and a comparable finding (30%–35%) was made for the other two treatment groups. The proportion of patients with impaired psychomotor speed was the highest (10%–15%) across various cognitive domains. Moreover, a significant proportion of NSCLC patients (15%–20%) exhibited HADS-defined anxiety and depression disorder. Finally, significant correlations were found between FACT-cog total scores and the HADS Depression subscale across all three groups. Conclusion: This study demonstrated that 1) a substantial proportion of NSCLC patients exhibited cognitive impairments (especially regarding psychomotor speed) and psychiatric disturbances; 2) no significant differences were observed among the three patient groups for any subjective or objective measure of cognitive deficit; and 3) perceived cognitive impairment was significantly associated with depression or anxiety. Prompt treatment of psychiatric disorders to minimize their impact is therefore recommended. Keywords: non-small-cell lung cancer, neuropsychological performance, psychomotor speed, anxiety, depression
format	article
author	Kang HL Chen VCH Hung WL Hsiao HP Wang WH
author_facet	Kang HL Chen VCH Hung WL Hsiao HP Wang WH
author_sort	Kang HL
title	Preliminary comparison of neuropsychological performance in patients with non-small-cell lung cancer treated with chemotherapy or targeted therapy
title_short	Preliminary comparison of neuropsychological performance in patients with non-small-cell lung cancer treated with chemotherapy or targeted therapy
title_full	Preliminary comparison of neuropsychological performance in patients with non-small-cell lung cancer treated with chemotherapy or targeted therapy
title_fullStr	Preliminary comparison of neuropsychological performance in patients with non-small-cell lung cancer treated with chemotherapy or targeted therapy
title_full_unstemmed	Preliminary comparison of neuropsychological performance in patients with non-small-cell lung cancer treated with chemotherapy or targeted therapy
title_sort	preliminary comparison of neuropsychological performance in patients with non-small-cell lung cancer treated with chemotherapy or targeted therapy
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/2e85cad7f2bb48628ea71a4d803fd4a5
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Preliminary comparison of neuropsychological performance in patients with non-small-cell lung cancer treated with chemotherapy or targeted therapy

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