Polymorphisms in NQO1 and MPO genes and risk for bladder cancer in Tunisian population

Abstract Background NAD (P) H: quinone oxidoreductase (1) (NQO1‐HGNC: 2874) and myeloperoxidase (MPO‐HGNC: 7218) are two enzymes involved in phase II of the xenobiotic metabolism pathway. Methods In this study, a case–control analysis was conducted to investigate the relationship between genetic var...

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Autores principales:	Imen Hemissi, Haroun Ayed, Zeineb Naimi, Khedija Meddeb, Mouna Ayadi, Skander Zouari, Selim Zaghbib, Emna Talbi, Mohamed Chebil, Slah Ouerhani
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	benzene bladder cancer NQO1 and MPO polymorphism RFLP smoking Genetics QH426-470
Acceso en línea:	https://doaj.org/article/2e85fafc44e84500819fd38f83b14ce0
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spelling	oai:doaj.org-article:2e85fafc44e84500819fd38f83b14ce02021-11-21T19:38:53ZPolymorphisms in NQO1 and MPO genes and risk for bladder cancer in Tunisian population2324-926910.1002/mgg3.1819https://doaj.org/article/2e85fafc44e84500819fd38f83b14ce02021-11-01T00:00:00Zhttps://doi.org/10.1002/mgg3.1819https://doaj.org/toc/2324-9269Abstract Background NAD (P) H: quinone oxidoreductase (1) (NQO1‐HGNC: 2874) and myeloperoxidase (MPO‐HGNC: 7218) are two enzymes involved in phase II of the xenobiotic metabolism pathway. Methods In this study, a case–control analysis was conducted to investigate the relationship between genetic variations in the NQO1 (C609T, rs1800566; IVS1‐27 C >G, rs689452) and MPO (G463A, rs2333227) genes and the risk for bladder cancer among Tunisian population. Results We have found that the MPO 463GA genotype was associated with a decreased risk of developing bladder cancer (p = 0.049; OR = 0.696; 95% CI 0.484–0.999). In contrast, we have found that the NQO1 609CT genotype could increase the risk of bladder cancer patients (p = 0.0039; OR = 1.454; 95% CI = 1.017–2.078). Moreover, patients with “NQO1 609 CT/IVS1‐27 CG” genotype show a 2.180‐fold increasing risk for developing bladder cancer in comparison to the control group with wild genotype. This OR is estimated at 5.6‐fold in smokers patients with “NQO1 609 CT/IVS1‐27 CG” genotype. Lastly, study findings suggest that the NQO1 IVS‐27 *CG genotype (rs689452) is associated with a risk of progression to muscle invasive bladder cancer. Conclusion Our study suggests that environmental risk factors in association to NQO1 genotypes (NQO1 609 CT/IVS1‐27 CG) play an important role in the development of bladder cancer in Tunisian population.Imen HemissiHaroun AyedZeineb NaimiKhedija MeddebMouna AyadiSkander ZouariSelim ZaghbibEmna TalbiMohamed ChebilSlah OuerhaniWileyarticlebenzenebladder cancerNQO1 and MPO polymorphismRFLPsmokingGeneticsQH426-470ENMolecular Genetics & Genomic Medicine, Vol 9, Iss 11, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	benzene bladder cancer NQO1 and MPO polymorphism RFLP smoking Genetics QH426-470
spellingShingle	benzene bladder cancer NQO1 and MPO polymorphism RFLP smoking Genetics QH426-470 Imen Hemissi Haroun Ayed Zeineb Naimi Khedija Meddeb Mouna Ayadi Skander Zouari Selim Zaghbib Emna Talbi Mohamed Chebil Slah Ouerhani Polymorphisms in NQO1 and MPO genes and risk for bladder cancer in Tunisian population
description	Abstract Background NAD (P) H: quinone oxidoreductase (1) (NQO1‐HGNC: 2874) and myeloperoxidase (MPO‐HGNC: 7218) are two enzymes involved in phase II of the xenobiotic metabolism pathway. Methods In this study, a case–control analysis was conducted to investigate the relationship between genetic variations in the NQO1 (C609T, rs1800566; IVS1‐27 C >G, rs689452) and MPO (G463A, rs2333227) genes and the risk for bladder cancer among Tunisian population. Results We have found that the MPO 463GA genotype was associated with a decreased risk of developing bladder cancer (p = 0.049; OR = 0.696; 95% CI 0.484–0.999). In contrast, we have found that the NQO1 609CT genotype could increase the risk of bladder cancer patients (p = 0.0039; OR = 1.454; 95% CI = 1.017–2.078). Moreover, patients with “NQO1 609 CT/IVS1‐27 CG” genotype show a 2.180‐fold increasing risk for developing bladder cancer in comparison to the control group with wild genotype. This OR is estimated at 5.6‐fold in smokers patients with “NQO1 609 CT/IVS1‐27 CG” genotype. Lastly, study findings suggest that the NQO1 IVS‐27 *CG genotype (rs689452) is associated with a risk of progression to muscle invasive bladder cancer. Conclusion Our study suggests that environmental risk factors in association to NQO1 genotypes (NQO1 609 CT/IVS1‐27 CG) play an important role in the development of bladder cancer in Tunisian population.
format	article
author	Imen Hemissi Haroun Ayed Zeineb Naimi Khedija Meddeb Mouna Ayadi Skander Zouari Selim Zaghbib Emna Talbi Mohamed Chebil Slah Ouerhani
author_facet	Imen Hemissi Haroun Ayed Zeineb Naimi Khedija Meddeb Mouna Ayadi Skander Zouari Selim Zaghbib Emna Talbi Mohamed Chebil Slah Ouerhani
author_sort	Imen Hemissi
title	Polymorphisms in NQO1 and MPO genes and risk for bladder cancer in Tunisian population
title_short	Polymorphisms in NQO1 and MPO genes and risk for bladder cancer in Tunisian population
title_full	Polymorphisms in NQO1 and MPO genes and risk for bladder cancer in Tunisian population
title_fullStr	Polymorphisms in NQO1 and MPO genes and risk for bladder cancer in Tunisian population
title_full_unstemmed	Polymorphisms in NQO1 and MPO genes and risk for bladder cancer in Tunisian population
title_sort	polymorphisms in nqo1 and mpo genes and risk for bladder cancer in tunisian population
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/2e85fafc44e84500819fd38f83b14ce0
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Polymorphisms in NQO1 and MPO genes and risk for bladder cancer in Tunisian population

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