Crystal structure of an intramembranal phosphatase central to bacterial cell-wall peptidoglycan biosynthesis and lipid recycling

Undecaprenyl pyrophosphate phosphatase (UppP) recycles the lipid carrier essential for bacterial cell wall synthesis. Here authors present the crystal structure of UppP from E. coli at 2.0 Å resolution, which sheds light on its phosphatase mechanism and indicates a potential flippase role for UppP.

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Autores principales:	Sean D. Workman, Liam J. Worrall, Natalie C. J. Strynadka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2e86e17751974345a1a2d3a330963722
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spelling	oai:doaj.org-article:2e86e17751974345a1a2d3a3309637222021-12-02T16:49:34ZCrystal structure of an intramembranal phosphatase central to bacterial cell-wall peptidoglycan biosynthesis and lipid recycling10.1038/s41467-018-03547-82041-1723https://doaj.org/article/2e86e17751974345a1a2d3a3309637222018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03547-8https://doaj.org/toc/2041-1723Undecaprenyl pyrophosphate phosphatase (UppP) recycles the lipid carrier essential for bacterial cell wall synthesis. Here authors present the crystal structure of UppP from E. coli at 2.0 Å resolution, which sheds light on its phosphatase mechanism and indicates a potential flippase role for UppP.Sean D. WorkmanLiam J. WorrallNatalie C. J. StrynadkaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sean D. Workman Liam J. Worrall Natalie C. J. Strynadka Crystal structure of an intramembranal phosphatase central to bacterial cell-wall peptidoglycan biosynthesis and lipid recycling
description	Undecaprenyl pyrophosphate phosphatase (UppP) recycles the lipid carrier essential for bacterial cell wall synthesis. Here authors present the crystal structure of UppP from E. coli at 2.0 Å resolution, which sheds light on its phosphatase mechanism and indicates a potential flippase role for UppP.
format	article
author	Sean D. Workman Liam J. Worrall Natalie C. J. Strynadka
author_facet	Sean D. Workman Liam J. Worrall Natalie C. J. Strynadka
author_sort	Sean D. Workman
title	Crystal structure of an intramembranal phosphatase central to bacterial cell-wall peptidoglycan biosynthesis and lipid recycling
title_short	Crystal structure of an intramembranal phosphatase central to bacterial cell-wall peptidoglycan biosynthesis and lipid recycling
title_full	Crystal structure of an intramembranal phosphatase central to bacterial cell-wall peptidoglycan biosynthesis and lipid recycling
title_fullStr	Crystal structure of an intramembranal phosphatase central to bacterial cell-wall peptidoglycan biosynthesis and lipid recycling
title_full_unstemmed	Crystal structure of an intramembranal phosphatase central to bacterial cell-wall peptidoglycan biosynthesis and lipid recycling
title_sort	crystal structure of an intramembranal phosphatase central to bacterial cell-wall peptidoglycan biosynthesis and lipid recycling
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2e86e17751974345a1a2d3a330963722
work_keys_str_mv	AT seandworkman crystalstructureofanintramembranalphosphatasecentraltobacterialcellwallpeptidoglycanbiosynthesisandlipidrecycling AT liamjworrall crystalstructureofanintramembranalphosphatasecentraltobacterialcellwallpeptidoglycanbiosynthesisandlipidrecycling AT nataliecjstrynadka crystalstructureofanintramembranalphosphatasecentraltobacterialcellwallpeptidoglycanbiosynthesisandlipidrecycling
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Crystal structure of an intramembranal phosphatase central to bacterial cell-wall peptidoglycan biosynthesis and lipid recycling

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