PIF1 family DNA helicases suppress R-loop mediated genome instability at tRNA genes

The budding yeast genome encodes two Pif1 family helicases, Pif1 and Rrm3, previously shown to have distinct functions in the maintenance of telomeres and other aspects of genome stability. Here the authors identify a role for Pif1 (and Rrm3) in promoting DNA replication and suppressing R-loop media...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Phong Lan Thao Tran, Thomas J. Pohl, Chi-Fu Chen, Angela Chan, Sebastian Pott, Virginia A. Zakian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2e8870bb59154364bb030628f649dba0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2e8870bb59154364bb030628f649dba0
record_format	dspace
spelling	oai:doaj.org-article:2e8870bb59154364bb030628f649dba02021-12-02T17:06:17ZPIF1 family DNA helicases suppress R-loop mediated genome instability at tRNA genes10.1038/ncomms150252041-1723https://doaj.org/article/2e8870bb59154364bb030628f649dba02017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms15025https://doaj.org/toc/2041-1723The budding yeast genome encodes two Pif1 family helicases, Pif1 and Rrm3, previously shown to have distinct functions in the maintenance of telomeres and other aspects of genome stability. Here the authors identify a role for Pif1 (and Rrm3) in promoting DNA replication and suppressing R-loop mediated DNA damage at tRNA genes.Phong Lan Thao TranThomas J. PohlChi-Fu ChenAngela ChanSebastian PottVirginia A. ZakianNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Phong Lan Thao Tran Thomas J. Pohl Chi-Fu Chen Angela Chan Sebastian Pott Virginia A. Zakian PIF1 family DNA helicases suppress R-loop mediated genome instability at tRNA genes
description	The budding yeast genome encodes two Pif1 family helicases, Pif1 and Rrm3, previously shown to have distinct functions in the maintenance of telomeres and other aspects of genome stability. Here the authors identify a role for Pif1 (and Rrm3) in promoting DNA replication and suppressing R-loop mediated DNA damage at tRNA genes.
format	article
author	Phong Lan Thao Tran Thomas J. Pohl Chi-Fu Chen Angela Chan Sebastian Pott Virginia A. Zakian
author_facet	Phong Lan Thao Tran Thomas J. Pohl Chi-Fu Chen Angela Chan Sebastian Pott Virginia A. Zakian
author_sort	Phong Lan Thao Tran
title	PIF1 family DNA helicases suppress R-loop mediated genome instability at tRNA genes
title_short	PIF1 family DNA helicases suppress R-loop mediated genome instability at tRNA genes
title_full	PIF1 family DNA helicases suppress R-loop mediated genome instability at tRNA genes
title_fullStr	PIF1 family DNA helicases suppress R-loop mediated genome instability at tRNA genes
title_full_unstemmed	PIF1 family DNA helicases suppress R-loop mediated genome instability at tRNA genes
title_sort	pif1 family dna helicases suppress r-loop mediated genome instability at trna genes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2e8870bb59154364bb030628f649dba0
work_keys_str_mv	AT phonglanthaotran pif1familydnahelicasessuppressrloopmediatedgenomeinstabilityattrnagenes AT thomasjpohl pif1familydnahelicasessuppressrloopmediatedgenomeinstabilityattrnagenes AT chifuchen pif1familydnahelicasessuppressrloopmediatedgenomeinstabilityattrnagenes AT angelachan pif1familydnahelicasessuppressrloopmediatedgenomeinstabilityattrnagenes AT sebastianpott pif1familydnahelicasessuppressrloopmediatedgenomeinstabilityattrnagenes AT virginiaazakian pif1familydnahelicasessuppressrloopmediatedgenomeinstabilityattrnagenes
_version_	1718381664491536384

PIF1 family DNA helicases suppress R-loop mediated genome instability at tRNA genes

Ejemplares similares