Pediatric thalassemic patients have higher incidence of asthma: A nationwide population-based retrospective cohort study.

<h4>Introduction</h4>Patients with hemoglobinopathies have been reported to have higher rates of pulmonary complications. Few studies have investigated the association between thalassemia and asthma in children.<h4>Methods</h4>We used the data of one million individuals rando...

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Autores principales:	Hsin-Yi Hsieh, Lin-Chi Huang, Hong-Ren Yu, Kuang-Che Kuo, Wan-Hsuan Chen, Chung-Hao Su, Chuan-Pin Lee, Ko-Jung Chen, Yao-Hsu Yang, Jiunn-Ming Sheen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2e91dded84064c9baeee521c1466a165
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spelling	oai:doaj.org-article:2e91dded84064c9baeee521c1466a1652021-12-02T20:04:22ZPediatric thalassemic patients have higher incidence of asthma: A nationwide population-based retrospective cohort study.1932-620310.1371/journal.pone.0258727https://doaj.org/article/2e91dded84064c9baeee521c1466a1652021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258727https://doaj.org/toc/1932-6203<h4>Introduction</h4>Patients with hemoglobinopathies have been reported to have higher rates of pulmonary complications. Few studies have investigated the association between thalassemia and asthma in children.<h4>Methods</h4>We used the data of one million individuals randomly selected from the Registry for Beneficiaries of the National Health Insurance Research Database. One thalassemic child was matched with four control children without thalassemia according to sex, birth year, birth season, prematurity, and previous enteroviral infection.<h4>Results</h4>A total of 800 hundred thalassemic children and 3200 controls were included. Children with thalassemia had higher rates of developing asthma (41.81 vs 25.70 per 1000 person-years, P < 0.001) than the non-thalassemia controls with an adjusted hazard ratio of 1.37 (95% confidence interval [CI] = 1.19-1.58). Boys in the thalassemia cohort had a significantly higher adjusted incidence hazard ratio (IRR) of asthma than those in the non-thalassemia cohort (adjusted IRR = 1.45, 95% CI = 1.02-1.73). The risk of atopic and nonatopic asthma was higher in the thalassemia cohort than in the non-thalassemia cohort (IRR = 1.3, 1.61, respectively).<h4>Conclusions</h4>Children with thalassemia were more likely to develop asthma. More attention should be paid to the early diagnosis of asthma and prevention of asthma attacks.Hsin-Yi HsiehLin-Chi HuangHong-Ren YuKuang-Che KuoWan-Hsuan ChenChung-Hao SuChuan-Pin LeeKo-Jung ChenYao-Hsu YangJiunn-Ming SheenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0258727 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hsin-Yi Hsieh Lin-Chi Huang Hong-Ren Yu Kuang-Che Kuo Wan-Hsuan Chen Chung-Hao Su Chuan-Pin Lee Ko-Jung Chen Yao-Hsu Yang Jiunn-Ming Sheen Pediatric thalassemic patients have higher incidence of asthma: A nationwide population-based retrospective cohort study.
description	<h4>Introduction</h4>Patients with hemoglobinopathies have been reported to have higher rates of pulmonary complications. Few studies have investigated the association between thalassemia and asthma in children.<h4>Methods</h4>We used the data of one million individuals randomly selected from the Registry for Beneficiaries of the National Health Insurance Research Database. One thalassemic child was matched with four control children without thalassemia according to sex, birth year, birth season, prematurity, and previous enteroviral infection.<h4>Results</h4>A total of 800 hundred thalassemic children and 3200 controls were included. Children with thalassemia had higher rates of developing asthma (41.81 vs 25.70 per 1000 person-years, P < 0.001) than the non-thalassemia controls with an adjusted hazard ratio of 1.37 (95% confidence interval [CI] = 1.19-1.58). Boys in the thalassemia cohort had a significantly higher adjusted incidence hazard ratio (IRR) of asthma than those in the non-thalassemia cohort (adjusted IRR = 1.45, 95% CI = 1.02-1.73). The risk of atopic and nonatopic asthma was higher in the thalassemia cohort than in the non-thalassemia cohort (IRR = 1.3, 1.61, respectively).<h4>Conclusions</h4>Children with thalassemia were more likely to develop asthma. More attention should be paid to the early diagnosis of asthma and prevention of asthma attacks.
format	article
author	Hsin-Yi Hsieh Lin-Chi Huang Hong-Ren Yu Kuang-Che Kuo Wan-Hsuan Chen Chung-Hao Su Chuan-Pin Lee Ko-Jung Chen Yao-Hsu Yang Jiunn-Ming Sheen
author_facet	Hsin-Yi Hsieh Lin-Chi Huang Hong-Ren Yu Kuang-Che Kuo Wan-Hsuan Chen Chung-Hao Su Chuan-Pin Lee Ko-Jung Chen Yao-Hsu Yang Jiunn-Ming Sheen
author_sort	Hsin-Yi Hsieh
title	Pediatric thalassemic patients have higher incidence of asthma: A nationwide population-based retrospective cohort study.
title_short	Pediatric thalassemic patients have higher incidence of asthma: A nationwide population-based retrospective cohort study.
title_full	Pediatric thalassemic patients have higher incidence of asthma: A nationwide population-based retrospective cohort study.
title_fullStr	Pediatric thalassemic patients have higher incidence of asthma: A nationwide population-based retrospective cohort study.
title_full_unstemmed	Pediatric thalassemic patients have higher incidence of asthma: A nationwide population-based retrospective cohort study.
title_sort	pediatric thalassemic patients have higher incidence of asthma: a nationwide population-based retrospective cohort study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/2e91dded84064c9baeee521c1466a165
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Pediatric thalassemic patients have higher incidence of asthma: A nationwide population-based retrospective cohort study.

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