Routes and types of microbial infection in the pathology of pancreatic adenocarcinoma

Introduction/Objective. Pancreatic cancer may be accompanied by infections caused by various microorganisms. It is uncertain wheatear pancreatic infection precedes the development of cancer or vice versa. The aim of this study is to analyze routes of infections from the duodenum through the pancreat...

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Auteurs principaux:	Nikolić Dragan, Latinčić Stojan, Stojanović Miloš, Grubor Nikica, Ranin Lazar, Nation Brian
Format:	article
Langue:	EN SR
Publié:	Serbian Medical Society 2021
Sujets:	candida albicans pseudomonas aeruginosa pancreatic adenocarcinoma pancreas infections duodenum Medicine R
Accès en ligne:	https://doaj.org/article/2e9276004243488cade8423f8e08ce3e
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spelling	oai:doaj.org-article:2e9276004243488cade8423f8e08ce3e2021-11-10T07:28:09ZRoutes and types of microbial infection in the pathology of pancreatic adenocarcinoma0370-81792406-089510.2298/SARH200928071Nhttps://doaj.org/article/2e9276004243488cade8423f8e08ce3e2021-01-01T00:00:00Zhttp://www.doiserbia.nb.rs/img/doi/0370-8179/2021/0370-81792100071N.pdfhttps://doaj.org/toc/0370-8179https://doaj.org/toc/2406-0895Introduction/Objective. Pancreatic cancer may be accompanied by infections caused by various microorganisms. It is uncertain wheatear pancreatic infection precedes the development of cancer or vice versa. The aim of this study is to analyze routes of infections from the duodenum through the pancreatic duct to determine what types of microorganisms can get through this duct into the pancreas and nearby tissue. Methods. In patients subjected to cephalic duodenopancreatectomy (Whipple procedure) due to adenocarcinoma of the ampulla of Vater, the duodenum or head of the pancreas, swabs from duodenal mucosa, pancreatic duct, and pancreatic tissue at the line of the resection were taken. Microscopic slides were prepared directly from the patients’ specimens as well as from colonies on culture plates, and both were Gram stained. Results. Candida was present in all three types of swabs (duodenum, pancreatic duct, and tissue), while bacteria, depending on the species (Pseudomonas aeruginosa, α-hemolytic Streptococcus, coagulasenegative Staphylococcus, Enterococcus spp., Serratia spp.), were present in pancreatic duct or tissue, but not in the duodenum. Conclusion. There is a connection between the presence of microorganisms and pathology of the pancreatic adenocarcinoma. Results show that Candida infection originates from the duodenum, while bacterial infections originate directly from blood or tissue injuries.Nikolić DraganLatinčić StojanStojanović MilošGrubor NikicaRanin LazarNation BrianSerbian Medical Societyarticlecandida albicanspseudomonas aeruginosapancreatic adenocarcinomapancreas infectionsduodenumMedicineRENSRSrpski Arhiv za Celokupno Lekarstvo, Vol 149, Iss 9-10, Pp 638-641 (2021)
institution	DOAJ
collection	DOAJ
language	EN SR
topic	candida albicans pseudomonas aeruginosa pancreatic adenocarcinoma pancreas infections duodenum Medicine R
spellingShingle	candida albicans pseudomonas aeruginosa pancreatic adenocarcinoma pancreas infections duodenum Medicine R Nikolić Dragan Latinčić Stojan Stojanović Miloš Grubor Nikica Ranin Lazar Nation Brian Routes and types of microbial infection in the pathology of pancreatic adenocarcinoma
description	Introduction/Objective. Pancreatic cancer may be accompanied by infections caused by various microorganisms. It is uncertain wheatear pancreatic infection precedes the development of cancer or vice versa. The aim of this study is to analyze routes of infections from the duodenum through the pancreatic duct to determine what types of microorganisms can get through this duct into the pancreas and nearby tissue. Methods. In patients subjected to cephalic duodenopancreatectomy (Whipple procedure) due to adenocarcinoma of the ampulla of Vater, the duodenum or head of the pancreas, swabs from duodenal mucosa, pancreatic duct, and pancreatic tissue at the line of the resection were taken. Microscopic slides were prepared directly from the patients’ specimens as well as from colonies on culture plates, and both were Gram stained. Results. Candida was present in all three types of swabs (duodenum, pancreatic duct, and tissue), while bacteria, depending on the species (Pseudomonas aeruginosa, α-hemolytic Streptococcus, coagulasenegative Staphylococcus, Enterococcus spp., Serratia spp.), were present in pancreatic duct or tissue, but not in the duodenum. Conclusion. There is a connection between the presence of microorganisms and pathology of the pancreatic adenocarcinoma. Results show that Candida infection originates from the duodenum, while bacterial infections originate directly from blood or tissue injuries.
format	article
author	Nikolić Dragan Latinčić Stojan Stojanović Miloš Grubor Nikica Ranin Lazar Nation Brian
author_facet	Nikolić Dragan Latinčić Stojan Stojanović Miloš Grubor Nikica Ranin Lazar Nation Brian
author_sort	Nikolić Dragan
title	Routes and types of microbial infection in the pathology of pancreatic adenocarcinoma
title_short	Routes and types of microbial infection in the pathology of pancreatic adenocarcinoma
title_full	Routes and types of microbial infection in the pathology of pancreatic adenocarcinoma
title_fullStr	Routes and types of microbial infection in the pathology of pancreatic adenocarcinoma
title_full_unstemmed	Routes and types of microbial infection in the pathology of pancreatic adenocarcinoma
title_sort	routes and types of microbial infection in the pathology of pancreatic adenocarcinoma
publisher	Serbian Medical Society
publishDate	2021
url	https://doaj.org/article/2e9276004243488cade8423f8e08ce3e
work_keys_str_mv	AT nikolicdragan routesandtypesofmicrobialinfectioninthepathologyofpancreaticadenocarcinoma AT latincicstojan routesandtypesofmicrobialinfectioninthepathologyofpancreaticadenocarcinoma AT stojanovicmilos routesandtypesofmicrobialinfectioninthepathologyofpancreaticadenocarcinoma AT grubornikica routesandtypesofmicrobialinfectioninthepathologyofpancreaticadenocarcinoma AT raninlazar routesandtypesofmicrobialinfectioninthepathologyofpancreaticadenocarcinoma AT nationbrian routesandtypesofmicrobialinfectioninthepathologyofpancreaticadenocarcinoma
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Routes and types of microbial infection in the pathology of pancreatic adenocarcinoma

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