Risk factors associated with osteoporosis and fracture in psoriatic arthritis

Risk factors associated with osteoporosis and fracture in psoriatic arthritis

Abstract. Background:. Although there are few studies mentioned there may be some relationship between psoriatic arthritis (PsA) and osteoporosis, clinical data in real world still need to be clarified in China. The aim of this study was to assess the areal and volumetric bone mineral density (BMD),...

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Autores principales: Yu Wang, Zhi-Bo Song, Xue-Rong Deng, Xiao-Hui Zhang, Zhuo-Li Zhang, Li-Shao Guo
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Publicado: Wolters Kluwer 2021
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Acceso en línea:https://doaj.org/article/2e92831b4409403d83931d667973bd8e
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spelling oai:doaj.org-article:2e92831b4409403d83931d667973bd8e2021-11-25T07:57:20ZRisk factors associated with osteoporosis and fracture in psoriatic arthritis0366-69992542-564110.1097/CM9.0000000000001810https://doaj.org/article/2e92831b4409403d83931d667973bd8e2021-11-01T00:00:00Zhttp://journals.lww.com/10.1097/CM9.0000000000001810https://doaj.org/toc/0366-6999https://doaj.org/toc/2542-5641Abstract. Background:. Although there are few studies mentioned there may be some relationship between psoriatic arthritis (PsA) and osteoporosis, clinical data in real world still need to be clarified in China. The aim of this study was to assess the areal and volumetric bone mineral density (BMD), frequency of fracture, and risk factors in patients with PsA. Methods:. A total of one hundred PsA patients who visited Peking University First Hospital and one hundred age- and sex-matched healthy controls with DXA data were enrolled in the study. Patients with clinical fractures confirmed by X-ray during follow-up were also recorded. Clinical characteristics of the patients were recorded and compared between the abnormal BMD group and the normal BMD group, as well as between the fracture and non-fracture groups. Risk factors for fracture and low BMD were analyzed. Results:. Mean BMD at the total hip and femoral neck was significantly lower in PsA patients than that in healthy controls (0.809 ± 0.193 vs. 0.901 ± 0.152 g/cm2, P = 0.041; 0.780 ± 0.146 vs. 0.865 ± 0.166 g/cm2, P = 0.037, respectively). Moreover, lumbar spine BMD was negatively correlated with psoriasis duration, swollen joint count and DAS28-CRP (r = –0.503, –0.580, –0.438; P < 0.05). Total hip BMD and femoral neck BMD were negatively correlated with HAQ (r = –0.521, –0.335; P < 0.05). Fractures occurred in 29 patients during the follow-up period. Logistic regression analysis showed that older age (OR 1.132 [95%CI: 1.026–1.248), P < 0.05], higher HAQ score (OR 1.493, 95%CI: 1.214–1.836, P < 0.01), higher disease activity index for psoriatic arthritis (OR 1.033, 95% CI: 1.002–1.679, P < 0.05) and hip joint involvement (OR 6.401, 95% CI: 4.012–44.180, P < 0.05) were risk factors for fracture in the multivariate model. Conclusions:. Increased risks of osteoporosis and fracture were found in PsA patients compared to healthy controls. Besides age, high disease activity and hip joint involvement were risk factors for decreased BMD and fracture.Yu WangZhi-Bo SongXue-Rong DengXiao-Hui ZhangZhuo-Li ZhangLi-Shao GuoWolters KluwerarticleMedicineRENChinese Medical Journal, Vol 134, Iss 21, Pp 2564-2572 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
spellingShingle Medicine
R
Yu Wang
Zhi-Bo Song
Xue-Rong Deng
Xiao-Hui Zhang
Zhuo-Li Zhang
Li-Shao Guo
Risk factors associated with osteoporosis and fracture in psoriatic arthritis
description Abstract. Background:. Although there are few studies mentioned there may be some relationship between psoriatic arthritis (PsA) and osteoporosis, clinical data in real world still need to be clarified in China. The aim of this study was to assess the areal and volumetric bone mineral density (BMD), frequency of fracture, and risk factors in patients with PsA. Methods:. A total of one hundred PsA patients who visited Peking University First Hospital and one hundred age- and sex-matched healthy controls with DXA data were enrolled in the study. Patients with clinical fractures confirmed by X-ray during follow-up were also recorded. Clinical characteristics of the patients were recorded and compared between the abnormal BMD group and the normal BMD group, as well as between the fracture and non-fracture groups. Risk factors for fracture and low BMD were analyzed. Results:. Mean BMD at the total hip and femoral neck was significantly lower in PsA patients than that in healthy controls (0.809 ± 0.193 vs. 0.901 ± 0.152 g/cm2, P = 0.041; 0.780 ± 0.146 vs. 0.865 ± 0.166 g/cm2, P = 0.037, respectively). Moreover, lumbar spine BMD was negatively correlated with psoriasis duration, swollen joint count and DAS28-CRP (r = –0.503, –0.580, –0.438; P < 0.05). Total hip BMD and femoral neck BMD were negatively correlated with HAQ (r = –0.521, –0.335; P < 0.05). Fractures occurred in 29 patients during the follow-up period. Logistic regression analysis showed that older age (OR 1.132 [95%CI: 1.026–1.248), P < 0.05], higher HAQ score (OR 1.493, 95%CI: 1.214–1.836, P < 0.01), higher disease activity index for psoriatic arthritis (OR 1.033, 95% CI: 1.002–1.679, P < 0.05) and hip joint involvement (OR 6.401, 95% CI: 4.012–44.180, P < 0.05) were risk factors for fracture in the multivariate model. Conclusions:. Increased risks of osteoporosis and fracture were found in PsA patients compared to healthy controls. Besides age, high disease activity and hip joint involvement were risk factors for decreased BMD and fracture.
format article
author Yu Wang
Zhi-Bo Song
Xue-Rong Deng
Xiao-Hui Zhang
Zhuo-Li Zhang
Li-Shao Guo
author_facet Yu Wang
Zhi-Bo Song
Xue-Rong Deng
Xiao-Hui Zhang
Zhuo-Li Zhang
Li-Shao Guo
author_sort Yu Wang
title Risk factors associated with osteoporosis and fracture in psoriatic arthritis
title_short Risk factors associated with osteoporosis and fracture in psoriatic arthritis
title_full Risk factors associated with osteoporosis and fracture in psoriatic arthritis
title_fullStr Risk factors associated with osteoporosis and fracture in psoriatic arthritis
title_full_unstemmed Risk factors associated with osteoporosis and fracture in psoriatic arthritis
title_sort risk factors associated with osteoporosis and fracture in psoriatic arthritis
publisher Wolters Kluwer
publishDate 2021
url https://doaj.org/article/2e92831b4409403d83931d667973bd8e
work_keys_str_mv AT yuwang riskfactorsassociatedwithosteoporosisandfractureinpsoriaticarthritis
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AT xuerongdeng riskfactorsassociatedwithosteoporosisandfractureinpsoriaticarthritis
AT xiaohuizhang riskfactorsassociatedwithosteoporosisandfractureinpsoriaticarthritis
AT zhuolizhang riskfactorsassociatedwithosteoporosisandfractureinpsoriaticarthritis
AT lishaoguo riskfactorsassociatedwithosteoporosisandfractureinpsoriaticarthritis
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